2-(diethylamino)ethyl pivalate | 21951-43-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(diethylamino)ethyl pivalate
• 英文别名: 2-(Diethylamino)ethyl 2,2-dimethylpropanoate；2-(diethylamino)ethyl 2,2-dimethylpropanoate
• CAS: 21951-43-9
• 化学式: C₁₁H₂₃NO₂
• 分子量: 201.309
• InChiKey: DZZLVXFRRMPMQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  三甲基乙酰氯 、 三乙胺 在 potassium tetrachloroplatinate(II) 、 copper(II) choride dihydrate 、 硫酸 、 水 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 27.0h， 以88%的产率得到2-(diethylamino)ethyl pivalate
  参考文献：
  名称：

  脂肪胺的铂催化、末端选择性 C(sp3)-H 氧化

  摘要：

  本通讯描述了脂肪胺的终端选择性、Pt 催化的 C(sp(3))-H 氧化，无需定向基团。CuCl2 用作化学计量氧化剂，在 Pt 负载量低至 1 mol% 的情况下，反应以高产率进行。这些转化是在硫酸存在下进行的，硫酸与胺底物原位反应形成铵盐。我们建议胺的质子化至少起到三个重要作用：（i）它使底物可溶于水性反应介质中；(ii) 它限制胺氮与 Pt 或 Cu 的结合；(iii) 它以电子方式使靠近氮中心的 CH 键失活。我们证明该策略对各种伯胺、仲胺和叔胺的终端选择性 C(sp(3))-H 氧化是有效的。

  DOI：

  10.1021/jacs.5b09099

文献信息

• 3-CARBAMOYL-2-PYRIDONE DERIVATIVES
  申请人：ISHIZUKA Natsuki

  公开号：US20120208813A1

  公开（公告）日：2012-08-16

  The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R 1 , R 2 , R 3 , R 4 , and G are defined as herein, a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral used and for external application, which each contains the said compound as an active ingredient.

  本发明提供了具有激动大麻素受体的活性的化合物，该受体由公式（I）表示：其中R1、R2、R3、R4和G如本文所定义，其药学上可接受的盐或溶剂，以及制备该化合物为活性成分的药物组合物、治疗特应性皮炎的药剂和抗瘙痒剂，尤其是用于口服和外用的抗瘙痒剂。
• ION COMPLEX MATERIAL HAVING ABILITY TO INHIBIT ADHESION OF BIOLOGICAL MATERIALS, AND METHOD FOR PRODUCING SAME
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP3231825A1

  公开（公告）日：2017-10-18

  The present invention provides a copolymer or the like obtained by polymerizing a monomer mixture including at least compounds represented by formulas (A), (B), and (C) (in the formulas, Ta, Tb, Tc, Ua1, Ua2, Ub1, Ub2, Ub3, Qa, Qb, Qc, Ra, Rb, Rc, An-, and m are as defined in the description and claims). The copolymer of the present invention can be utilized as an ion complex material having an exceptional ability to inhibit adhesion of biological materials.

  本发明提供了一种共聚物或类似物，该共聚物通过聚合至少包括式（A）、（B）和（C）所代表化合物的单体混合物而获得（式中，Ta、Tb、Tc、Ua1、Ua2、Ub1、Ub2、Ub3、Qa、Qb、Qc、Ra、Rb、Rc、An- 和 m 如说明和权利要求中所定义）。本发明的共聚物可用作离子络合材料，具有抑制生物材料粘附的特殊能力。
• 3-CARBAMOYL-2-PYRIDONE DERIVATIVE
  申请人：SHIONOGI & CO., LTD.

  公开号：EP1806342B1

  公开（公告）日：2013-04-17
• CELL CULTURE VESSEL
  申请人：NISSAN CHEMICAL CORPORATION

  公开号：US20190233792A1

  公开（公告）日：2019-08-01

  The present invention provides a cell culture vessel having a surface coated with a copolymer including a repeating unit containing a group represented by the following formula (a), a repeating unit containing a group represented by the following formula (b), and a repeating unit containing a group represented by the following formula (c) (wherein U a1 , U a2 , U b1 , U b2 , U b3 , R c and An − are as defined in the description and the claims). The invention also provides a method for producing such cell culture vessels, and a method for producing a cell aggregate using the vessel.
• CELL CULTURE CONTAINER CAPABLE OF LONG-TERM CULTURE AND METHOD FOR MANUFACTURING SAME
  申请人：NISSAN CHEMICAL CORPORATION

  公开号：US20200369999A1

  公开（公告）日：2020-11-26

  The present invention provides a cell culture container for long term non-adherent cell culture which comprises having a coating containing a copolymer which is a copolymer having a recurring unit which contains a group represented by the following formula (a), a recurring unit which contains a group represented by the following formula (b), and a recurring unit which contains a group represented by the following formula (c), and a molar ratio of the recurring unit which contains a group represented by the formula (c) being 1 to 50 mol % based on the whole copolymer, provided with at least a part of a surface thereof [wherein, U a1 , U a2 , U b1 , U b2 and U b3 , R c , and An − are as defined in the specification and Claims.]