2,2-dimethyl-5-hexen-1,3-diol | 138832-34-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-dimethyl-5-hexen-1,3-diol
• 英文别名: 2,2-Dimethylhex-5-ene-1,3-diol
• CAS: 138832-34-5
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: IJNKEFJDDPWKQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-5-hexen-1,3-diol 、 2,2-二甲氧基丙烷 在 camphor-10-sulfonic acid 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以86%的产率得到4-allyl-2,2,5,5-tetramethyl-1,3-dioxane
  参考文献：
  名称：

  Synthesis of the macrolactone structure of the aurisides

  摘要：

  The core Structure of the aurisides has been reached by the coupling of three subunits including as key step a cross/metathesis/hydrogenation/ketalisation sequence. the addition of a vinyl lithium derivative onto an aldehyde and finally a lactonization Under Yamaguchi's conditions (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.008
• 作为产物：
  描述：

  1-(tert-butyldimethylsilanyloxy)-2,2-dimethyl-5-hexen-3-ol 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以95%的产率得到2,2-dimethyl-5-hexen-1,3-diol
  参考文献：
  名称：

  Synthesis of the macrolactone structure of the aurisides

  摘要：

  The core Structure of the aurisides has been reached by the coupling of three subunits including as key step a cross/metathesis/hydrogenation/ketalisation sequence. the addition of a vinyl lithium derivative onto an aldehyde and finally a lactonization Under Yamaguchi's conditions (C) 2009 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.008

文献信息

• Organometallic reactions in aqueous media with indium
  作者：C.J. Li、T.H. Chan

  DOI：10.1016/0040-4039(91)85028-4

  日期：1991.11

  Allylation reactions of aldehydes and ketones occurred smoothly with indium metal in aqueous media. Compared to similar reactions with zinc and tin, the reaction with indium proceeds without the need of any promoter. The reaction can be extended to the synthesis of 2-methylene-γ-lactone 6 via the condensation of carbonyl compounds with 2-bromomethylacrylate 4.

  醛和酮的烯丙基化反应与铟金属在水性介质中的反应平稳进行。与与锌和锡的类似反应相比，与铟的反应无需任何促进剂即可进行。该反应可扩展到2-亚甲基γ内酯的合成6通过羰基化合物的缩合与2- bromomethylacrylate 4。
• Synthesis of the macrolactone structure of the aurisides
  作者：Emmanuel Bourcet、Fabienne Fache、Olivier Piva

  DOI：10.1016/j.tet.2009.12.008

  日期：2010.2

  The core Structure of the aurisides has been reached by the coupling of three subunits including as key step a cross/metathesis/hydrogenation/ketalisation sequence. the addition of a vinyl lithium derivative onto an aldehyde and finally a lactonization Under Yamaguchi's conditions (C) 2009 Elsevier Ltd All rights reserved