N-(N'-Ethyl-2-aminoethyl)-p-nitrobenzamide | 76806-96-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(N'-Ethyl-2-aminoethyl)-p-nitrobenzamide
• 英文别名: N-2-(Ethylamino)ethyl-4-nitrobenzamide；N-(N'-ethyl 2-aminoethyl) p-nitrobenzamide；N-(N'-ethyl 2-aminoethyl)-p-nitrobenzamide；N-(N'ethyl-2-aminoethyl)-p-nitrobenzamide；N-(2-(ethylamino)ethyl)-4-nitrobenzamide；N-[2-(ethylamino)ethyl]-4-nitrobenzamide
• CAS: 76806-96-7
• 化学式: C₁₁H₁₅N₃O₃
• mdl: MFCD18006152
• 分子量: 237.258
• InChiKey: RLAWNAMGBQKTAP-UHFFFAOYSA-N

物化性质

• 沸点：
  443.7±30.0 °C(Predicted)
• 密度：
  1.186±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  87
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(N'-Ethyl-2-aminoethyl)-p-nitrobenzamide 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以63%的产率得到4-Amino-N-[2-(ethylamino)ethyl]benzamide hydrochloride
  参考文献：
  名称：

  SYNTHESIS OF PROCAINAMIDE METABOLITES. N-ACETYL DESETHYLPROCAINAMIDE AND DESETHYLPROCAINAMIDE

  摘要：

  DOI：

  10.1080/00304949609356555
• 作为产物：
  描述：

  N-乙基乙二胺 、 4-硝基苯甲酰氯 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 0.25h， 以39%的产率得到N-(N'-Ethyl-2-aminoethyl)-p-nitrobenzamide
  参考文献：
  名称：

  WO2008/33744

  摘要：

  公开号：

文献信息

• Procainamide assay, tracers, immunogens and antibodies
  申请人：ABBOTT LABORATORIES

  公开号：EP0199042A1

  公开（公告）日：1986-10-29

  The present invention is directed to a fluorescence polarization immunoassay for procainamide, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them. The tracers and the immunogens are made from analogs of procainamide. A fluorescein moiety is included in the tracer while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of ' polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

  该发明涉及一种用于普鲁卡因胺的荧光偏振免疫分析，以及制备和执行此类分析所需的各种组分，以及制造这些组分的方法。具体地，揭示了示踪剂、免疫原和抗体，以及制造它们的方法。示踪剂和免疫原是由普鲁卡因胺的类似物制成的。示踪剂中包含荧光基团，而多肽（氨基酸）是免疫原的一部分。该分析通过测量通过含有抗血清和示踪剂的样品的偏振保留度来进行，该样品已经通过平面偏振光。
• Procainamide antigen conjugates and antibodies
  申请人：Syva Company

  公开号：US04235969A1

  公开（公告）日：1980-11-25

  Compounds are provided for use in the preparation of reagents which can be used in immunoassays for the determination of benzamides of N,N-dialkylethyleneamines. A linking group is provided, at a particular site of the drug, which provides a link between the above compounds and an antigen, with the resulting conjugate being employed for the preparation of antibodies. The antibodies find particular use in competitive protein binding assays. Conjugates to enzymes are prepared which find particular use in homogeneous enzyme immunoassays.

  该复合物可用于制备试剂，以用于免疫测定法中测定N，N-二烷基乙烯胺的苯甲酰胺。该药物的特定位置提供了连接基团，用于连接上述化合物和抗原，从而制备出共轭物，用于抗体的制备。这些抗体在竞争性蛋白结合测定法中发挥特殊作用。制备酶的共轭物，在均相酶免疫测定法中发挥特殊作用。
• Multi-Functional Small Molecules as Anti-Proliferative Agents
  申请人：Cai Xiong

  公开号：US20080221132A1

  公开（公告）日：2008-09-11

  The present invention relates to the compositions, methods, and applications of a novel approach to selective inhibition of several cellular or molecular targets with a single small molecule. More specifically, the present invention relates to multi-functional small molecules wherein one functionality is capable of inhibiting histone deacetylases (HDAC) and the other functionality is capable of inhibiting a different cellular or molecular pathway involved in aberrant cell proliferation, differentiation or survival.

  本发明涉及一种新型选择性抑制多种细胞或分子靶点的组合物、方法和应用。更具体地说，本发明涉及多功能小分子，其中一种功能能够抑制组蛋白去乙酰化酶（HDAC），另一种功能能够抑制与异常细胞增殖、分化或存活有关的不同细胞或分子途径。
• DNA METHYL TRANSFERASE INHIBITORS CONTAINING A ZINC BINDING MOIETY
  申请人：Cai Xiong

  公开号：US20080234355A1

  公开（公告）日：2008-09-25

  The present invention relates to inhibitors of DNMT containing zinc moiety derivatives that have enhanced or unique properties as inhibitors of DNA methyl transferases (DNMT) and their use in the treatment of DNMT related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

  本发明涉及含锌基衍生物的DNMT抑制剂，其具有增强或独特的抑制DNA甲基转移酶（DNMT）的性质，并且可用于治疗DNMT相关的疾病和疾病，如癌症。所述衍生物还可以作为HDAC抑制剂。
• [EN] MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS<br/>[FR] PETITES MOLÉCULES MULTIFONCTIONNELLES SERVANT D'AGENTS ANTI-PROLIFÉRATIFS
  申请人：CURIS INC

  公开号：WO2008033747A3

  公开（公告）日：2008-12-04