TM-2-101 | 1338802-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: TM-2-101
• 英文别名: N-(biphenyl-4-ylmethylcarbamothioyl)benzamide；N-[(4-phenylphenyl)methylcarbamothioyl]benzamide
• CAS: 1338802-32-6
• 化学式: C₂₁H₁₈N₂OS
• 分子量: 346.453
• InChiKey: UCHPBXXJEMMUSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  73.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯甲酰氯 以 丙酮 为溶剂， 反应 1.0h， 生成 TM-2-101
  参考文献：
  名称：

  Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate

  摘要：

  We report, for the first time, that certain N-acetylthiourea derivatives serve as highly potent and isozyme selective activators for the recombinant form of human histone deacetylase-8 in the assay system containing Fluor-de-Lys as a fluorescent substrate. The experimental data reveals that such activating feature is manifested via decrease in the K-m value of the enzyme's substrate and increase in the catalytic turnover rate of the enzyme. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.07.080

文献信息

• Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate
  作者：Raushan K. Singh、Tanmay Mandal、Narayanaganesh Balsubramanian、Tajae Viaene、Travis Leedahl、Nitesh Sule、Gregory Cook、D.K. Srivastava

  DOI：10.1016/j.bmcl.2011.07.080

  日期：2011.8

  We report, for the first time, that certain N-acetylthiourea derivatives serve as highly potent and isozyme selective activators for the recombinant form of human histone deacetylase-8 in the assay system containing Fluor-de-Lys as a fluorescent substrate. The experimental data reveals that such activating feature is manifested via decrease in the K-m value of the enzyme's substrate and increase in the catalytic turnover rate of the enzyme. (C) 2011 Elsevier Ltd. All rights reserved.