(1R)-N-methyl-N-[(1R)-1-[2-[[2-[(1R)-1-[methyl-[(1R)-1-phenylethyl]amino]ethyl]phenyl]diselanyl]phenyl]ethyl]-1-phenylethanamine | 333390-16-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1R)-N-methyl-N-[(1R)-1-[2-[[2-[(1R)-1-[methyl-[(1R)-1-phenylethyl]amino]ethyl]phenyl]diselanyl]phenyl]ethyl]-1-phenylethanamine
• CAS: 333390-16-2
• 化学式: C₃₄H₄₀N₂Se₂
• 分子量: 634.625
• InChiKey: HCXWMWWHHFJTHV-BIYDSLDMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.47
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-丙烯基苯 、 (1R)-N-methyl-N-[(1R)-1-[2-[[2-[(1R)-1-[methyl-[(1R)-1-phenylethyl]amino]ethyl]phenyl]diselanyl]phenyl]ethyl]-1-phenylethanamine 在 ammonium persulfate 、 三氟甲磺酸 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 60.0h， 以82%的产率得到
  参考文献：
  名称：

  New nitrogen containing chiral diselenides: synthesis and asymmetric addition reactions to olefins

  摘要：

  A simple synthesis of two new nitrogen containing diselenides, 7 and 8, is described. These compounds were employed as starting materials to effect the asymmetric methoxyselenenylation, the hydroxyselenenylation as well as the cyclofunctionalization of olefins. Starting from 7 all these addition processes occurred with good facial selectivity. Poor results were however obtained with 8. One-pot selenenylation-elimination sequences using catalytic amounts of the diselenide 7 have also been investigated. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(00)00469-9
• 作为产物：
  描述：

  在 selenium 、 甲酸 、 叔丁基锂 、 三乙酰氧基硼氢化钠 作用下， 以 溶剂黄146 为溶剂， 生成 (1R)-N-methyl-N-[(1R)-1-[2-[[2-[(1R)-1-[methyl-[(1R)-1-phenylethyl]amino]ethyl]phenyl]diselanyl]phenyl]ethyl]-1-phenylethanamine
  参考文献：
  名称：

  New nitrogen containing chiral diselenides: synthesis and asymmetric addition reactions to olefins

  摘要：

  A simple synthesis of two new nitrogen containing diselenides, 7 and 8, is described. These compounds were employed as starting materials to effect the asymmetric methoxyselenenylation, the hydroxyselenenylation as well as the cyclofunctionalization of olefins. Starting from 7 all these addition processes occurred with good facial selectivity. Poor results were however obtained with 8. One-pot selenenylation-elimination sequences using catalytic amounts of the diselenide 7 have also been investigated. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(00)00469-9

文献信息

• New nitrogen containing chiral diselenides: synthesis and asymmetric addition reactions to olefins
  作者：Marcello Tiecco、Lorenzo Testaferri、Claudio Santi、Cristina Tomassini、Francesca Marini、Luana Bagnoli、Andrea Temperini

  DOI：10.1016/s0957-4166(00)00469-9

  日期：2000.12

  A simple synthesis of two new nitrogen containing diselenides, 7 and 8, is described. These compounds were employed as starting materials to effect the asymmetric methoxyselenenylation, the hydroxyselenenylation as well as the cyclofunctionalization of olefins. Starting from 7 all these addition processes occurred with good facial selectivity. Poor results were however obtained with 8. One-pot selenenylation-elimination sequences using catalytic amounts of the diselenide 7 have also been investigated. (C) 2001 Published by Elsevier Science Ltd.