2-(4-methoxyphenyl)octan-3-one | 918540-62-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-methoxyphenyl)octan-3-one
• 英文别名: 2-(4-Methoxyphenyl)octan-3-one
• CAS: 918540-62-2
• 化学式: C₁₅H₂₂O₂
• 分子量: 234.338
• InChiKey: WYTBQXWHUCCAOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-溴苯甲醚 、 1-辛烯-3-醇 在 palladium diacetate 四丁基溴化铵 、 碳酸氢钠 作用下， 反应 4.0h， 生成 2-(4-methoxyphenyl)octan-3-one 、 1-(4-methoxyphenyl)octan-3-one
  参考文献：
  名称：

  Palladium-Catalyzed Heck Arylations of Allyl Alcohols in Ionic Liquids: Remarkable Base Effect on the Selectivity

  摘要：

  Pd-catalyzed Heck arylation of allyl alcohols in tetraalkylammoniumionic liquids (ILs) can be made highly selective toward the formation of either aromatic carbonyl compounds or aromatic conjugated alcohols by carefully choosing both the IL and the base.

  DOI：

  10.1021/jo070005f

文献信息

• Arenediazonium <i>o</i>-Benzenedisulfonimides in Heck-Type Arylation of Allylic Alcohols
  作者：Margherita Barbero、Silvano Cadamuro、Stefano Dughera

  DOI：10.1055/s-2006-950245

  日期：2006.10

  with primary and secondary allylic alcohols. The reactions, carried out in aqueous ethanol in the presence of palladium(II) acetate as precatalyst and sodium hydrogen carbonate as base, gave the arylation products with good overall conversion. In all cases, the major products were the β-arylated carbonyl derivatives. The o-benzene-disulfonimide was recovered in high yield from all the reactions, and it

  芳烃重氮邻苯二磺酰亚胺与伯和仲烯丙醇反应。在醋酸钯 (II) 作为预催化剂和碳酸氢钠作为碱的存在下，在含水乙醇中进行的反应得到了具有良好总转化率的芳基化产物。在所有情况下，主要产物都是 β-芳基化羰基衍生物。从所有反应中以高收率回收邻苯二磺酰亚胺，并将其循环用于制备其他盐。
• Two efficient pathways for the synthesis of aryl ketones catalyzed by phosphorus-free palladium catalysts
  作者：A. Wirwis、J. Feder-Kubis、A.M. Trzeciak

  DOI：10.1016/j.mcat.2017.10.021

  日期：2018.2

  Allylic alcohols, 1-buten-3-ol, 1-penten-3-ol and 1-octen-3-ol, reacted with aryl iodides (iodotoluene, 4-iodotoluene, 4-iodophenol and 4-iodanisole) under Heck reaction conditions to form corresponding saturated aryl ketones in one step. The same products were obtained in a two-step tandem reaction consisted of the Heck coupling of allylic alcohols with aryl iodides, followed by hydrogenation. Reactions

  在Heck反应条件下，烯丙醇1-丁烯-3-醇，1-戊烯-3-醇和1-辛烯-3-醇与芳基碘化物（碘代甲苯，4-碘代甲苯，4-碘苯酚和4-碘苯甲醚）反应一步形成相应的饱和芳基酮 在两步串联反应中获得了相同的产物，该反应由烯丙基醇与芳基碘化物的Heck偶联组成，然后进行氢化。通过用薄荷醇取代的咪唑鎓氯化物改性的无磷钯前体催化反应。通过TEM证实在反应混合物中形成直径高达65nm的结晶钯纳米颗粒。
• Palladium-Catalyzed Heck Arylations of Allyl Alcohols in Ionic Liquids: Remarkable Base Effect on the Selectivity
  作者：Vincenzo Calò、Angelo Nacci、Antonio Monopoli、Valentina Ferola

  DOI：10.1021/jo070005f

  日期：2007.3.1

  Pd-catalyzed Heck arylation of allyl alcohols in tetraalkylammoniumionic liquids (ILs) can be made highly selective toward the formation of either aromatic carbonyl compounds or aromatic conjugated alcohols by carefully choosing both the IL and the base.