(E)-ethyl 2-(hydroxymethyl)dec-4-enoate | 1347744-67-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-ethyl 2-(hydroxymethyl)dec-4-enoate
• 英文别名: ethyl (E)-2-(hydroxymethyl)dec-4-enoate
• CAS: 1347744-67-5
• 化学式: C₁₃H₂₄O₃
• 分子量: 228.332
• InChiKey: UOOMQJZMIRQZCY-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-辛烯-3-醇 在 三乙烯二胺 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 反应 16.67h， 生成 (E)-ethyl 2-(hydroxymethyl)dec-4-enoate
  参考文献：
  名称：

  A one-pot synthesis of α-formyl-α-allylacetates via nucleophilic catalysis

  摘要：

  A step-economical one-pot nucleophilic catalysis/thermal Claisen-rearrangement protocol for the direct synthesis of alpha-formyl-alpha-allylacetates from allylic alcohols and activated alkynes has been developed. The product alpha-formyl-alpha-allylacetates were further reacted in situ to give either protected enol ethers or beta-hydroxy-4-pentenoates. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.035

文献信息

• A one-pot synthesis of α-formyl-α-allylacetates via nucleophilic catalysis
  作者：William Chung、Petra Lindovska、Jason E. Camp

  DOI：10.1016/j.tetlet.2011.10.035

  日期：2011.12

  A step-economical one-pot nucleophilic catalysis/thermal Claisen-rearrangement protocol for the direct synthesis of alpha-formyl-alpha-allylacetates from allylic alcohols and activated alkynes has been developed. The product alpha-formyl-alpha-allylacetates were further reacted in situ to give either protected enol ethers or beta-hydroxy-4-pentenoates. (C) 2011 Elsevier Ltd. All rights reserved.