2-巯基-L-色氨酸 | 38327-45-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 2-巯基-L-色氨酸
• 中文别名: L-2-巯基色氨酸
• 英文名称: (2S)-2-amino-3-(2-sulfanyl-1H-indol-3-yl)propanoic acid
• CAS: 38327-45-6
• 化学式: C₁₁H₁₂N₂O₂S
• 分子量: 236.29
• InChiKey: UDCPMOBROGCQJP-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  80.1
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Metallopeptide combinatorial libraries and applications
  申请人：——

  公开号：US20020012948A1

  公开（公告）日：2002-01-31

  Metallopeptide combinatorial libraries and methods of making libraries and metallopeptides are provided, for use in biological, pharmaceutical and related applications. The combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at least one orthogonal sulfur-protecting group, in which the peptide, peptidomimetic or construct is conformationally fixed on deprotection of the sulfur and complexation of the metal ion-binding region with a metal ion. Thereafter the library members may be screening to select those with the desired specificity and affinity.

  本发明提供了金属肽组合文库以及文库和金属肽的制造方法，可用于生物、制药和相关应用。组合文库由肽、拟肽物和肽样构建体组成，包括一个金属离子结合区，其中至少包括一个正交的硫保护基团，肽、拟肽物或构建体在硫的脱保护和金属离子结合区与金属离子络合时构象固定。之后，可对文库成员进行筛选，选出具有所需特异性和亲和力的成员。
• Cyclic peptide compositions and methods for treatment of sexual dysfunction
  申请人：——

  公开号：US20040138136A1

  公开（公告）日：2004-07-15

  A cyclic peptide of the structural formula: 1 or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and p are as defined. Further provided are compositions and methods for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cyclic peptide including a C-terminus —OH group. Methods of administration include injection, oral, urethral, vaginal, nasal and mucosal administration.

  一种环肽，其结构式为 1 或其药学上可接受的盐，其中 R 1 , R 2 , R 3 , R 4 , R 5 , R 6 m 和 p 的定义。进一步提供了通过给药包括 C 端 -OH 基团的环肽来治疗哺乳动物性功能障碍（包括男性性功能障碍，如勃起功能障碍）和女性性功能障碍的组合物和方法。给药方法包括注射、口服、尿道、阴道、鼻腔和粘膜给药。
• OPIOID METALLOPEPTIDE COMPOSITIONS AND METHODS
  申请人：Sharma D. Shubh

  公开号：US20050181447A1

  公开（公告）日：2005-08-18

  Metallopeptides and metallopeptide combinatorial libraries specific for opioids receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed in a biologically active configuration specific for one or more opioid receptors on complexation of a metal ion-binding portion thereof with a metal ion.

  本发明提供了针对阿片类受体的金属肽和金属肽组合库，可用于生物、制药和相关应用。这些金属肽和组合库由肽、拟肽物和肽样构建物组成，其中肽、拟肽物或构建物在其金属离子结合部分与金属离子络合时，构象固定为一种或多种阿片受体特异的生物活性构型。
• Methods for making metallopeptides and metallopeptide libraries
  申请人：Sharma D. Shubh

  公开号：US20060040324A1

  公开（公告）日：2006-02-23

  A method of making metallopeptide libraries and combinational libraries. The metallopeptide library members name a conformationally constrained global secondary structure obtained upon complexing with a metal ion. The metallopeptides are of the general formula: R 1 —X—R 2 where X is a plurality of amino acids and includes a complexing backbone for complexing metal ions, so that substantially all of the valences of the metal ion are satisfied upon complexation of the metal ion with X, resulting in a specific regional secondary structure forming a part of the global secondary structure; and where R 1 and R 2 each include from 0 to about 20 amino acids, the amino acids being selected so that upon complexing the metal ion with X at least a portion of either R 1 or R 2 or both have a structure forming the balance of the conformationally constrained global secondary structure.

  一种制造金属肽库和组合库的方法。金属肽文库的成员名称为与金属离子复合后获得的构象约束全局二级结构。金属肽的通式为 R 1 -X-R 2 其中 X 是多个氨基酸，并包括用于与金属离子络合的络合骨架，以便在金属离子与 X 络合时，金属离子的基本上所有价都得到满足，从而产生特定的区域二级结构，形成全局二级结构的一部分；以及 其中 R 1 和 R 2 各包括 0 至约 20 个氨基酸，选择这些氨基酸的目的是在金属离子与 X 复 合时，至少有一部分 R 1 或 R 2 或两者中至少有一部分具有形成构象约束全局二级结构平衡的结构。
• Opioid metallopeptide compositions and methods
  申请人：Sharma D. Shubh

  公开号：US20060083685A1

  公开（公告）日：2006-04-20

  Metallopeptides and metallopeptide combinatorial libraries specific for opioid receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed in a biologically active configuration specific for one or more opioid receptors on complexation of a metal ion-binding portion thereof with a metal ion.

  本发明提供了针对阿片受体的金属肽和金属肽组合库，可用于生物、制药和相关应用。这些金属肽和组合库由肽、肽模拟物和类肽构建物组成，其中肽、肽模拟物或构建物在其金属离子结合部分与金属离子络合时，构象固定为一种或多种阿片受体特异的生物活性构型。