3-(2-Dimethylamino-ethoxy)-4-methylaniline | 758711-89-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(2-Dimethylamino-ethoxy)-4-methylaniline
• 英文别名: 3-[2-(dimethylamino)ethoxy]-4-methylaniline
• CAS: 758711-89-6
• 化学式: C₁₁H₁₈N₂O
• 分子量: 194.277
• InChiKey: XCQLZAHVDGACHP-UHFFFAOYSA-N

物化性质

• 沸点：
  315.5±32.0 °C(Predicted)
• 密度：
  1.029±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-Dimethylamino-ethoxy)-4-methylaniline 在 tin(II) chloride dihdyrate 作用下， 以58%的产率得到3-(3,4-dichlorophenyl)-1-{3-[2-(dimethylamino)ethoxy]-4-methylphenyl}urea
  参考文献：
  名称：

  N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation

  摘要：

  提供了用于抑制翻译起始的组合物和方法。描述了使用N,N′-二芳基脲和/或N,N′-二芳基硫脲化合物治疗（1）细胞增殖性疾病，（2）非增殖性、退行性疾病，（3）病毒感染和/或（4）与病毒感染相关的疾病的组合物、方法和试剂盒。

  公开号：

  US09421211B2
• 作为产物：
  描述：

  dimethyl[2-(2-methyl-5-nitrophenoxy)ethyl]amine 在 tin(II) chloride dihdyrate 作用下， 以 乙醇 为溶剂， 反应 1.5h， 以202 mg的产率得到3-(2-Dimethylamino-ethoxy)-4-methylaniline
  参考文献：
  名称：

  N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation

  摘要：

  提供了用于抑制翻译起始的组合物和方法。描述了使用N,N′-二芳基脲和/或N,N′-二芳基硫脲化合物治疗（1）细胞增殖性疾病，（2）非增殖性、退行性疾病，（3）病毒感染和/或（4）与病毒感染相关的疾病的组合物、方法和试剂盒。

  公开号：

  US09421211B2

文献信息

• Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists
  申请人：Wu Chengde

  公开号：US20050054850A1

  公开（公告）日：2005-03-10

  The present invention relates to urotensin II receptor antagonists, pharmaceutical compositions containing them and their use.

  本发明涉及尿苷II受体拮抗剂，含有它们的药物组合物以及它们的用途。
• In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agents
  作者：Séverine Denoyelle、Ting Chen、Limo Chen、Yibo Wang、Edvin Klosi、José A. Halperin、Bertal H. Aktas、Michael Chorev

  DOI：10.1016/j.bmcl.2011.10.126

  日期：2012.1

  Symmetrical N,N'-diarylureas: 1,3-bis(3,4-dichlorophenyl)-, 1,3-bis[4-chloro-3-(trifluoromethyl)phenyl]- and 1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea, were identified as potent activators of the eIF2 alpha kinase heme regulated inhibitor. They reduce the abundance of the eIF2.GTP.tRNA(i)(Met) ternary complex and inhibit cancer cell proliferation. An optimization process was undertaken to improve their solubility while preserving their biological activity. Non-symmetrical hybrid ureas were generated by combining one of the hydrophobic phenyl moieties present in the symmetrical ureas with the polar 3-hydroxy-tolyl moiety. O-alkylation of the later added potentially solubilizing charge bearing groups. The new non-symmetrical N,N'-diarylureas were characterized by ternary complex reporter gene and cell proliferation assays, demonstrating good bioactivities. A representative sample of these compounds potently induced phosphorylation of eIF2 alpha and expression of CHOP at the protein and mRNA levels. These inhibitors of translation initiation may become leads for the development of potent, non-toxic, and target specific anti-cancer agents. (C) 2011 Elsevier Ltd. All rights reserved.
• PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS.
  申请人：ENCYSIVE PHARMACEUTICALS INC.

  公开号：EP1603884A2

  公开（公告）日：2005-12-14
• EP1603884A4
  申请人：——

  公开号：EP1603884A4

  公开（公告）日：2008-05-28
• US7265122B2
  申请人：——

  公开号：US7265122B2

  公开（公告）日：2007-09-04