2,4,6-octatrienyl palmitate | 1226758-31-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,4,6-octatrienyl palmitate
• 英文别名: [(2E,4E,6E)-octa-2,4,6-trienyl] hexadecanoate
• CAS: 1226758-31-1
• 化学式: C₂₄H₄₂O₂
• 分子量: 362.596
• InChiKey: ZAEYCXHWGGJVJL-VRCLXNGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (2E,4E,6E)-2,4,6-octatrien-1-ol 、 棕榈酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 5.0h， 以91%的产率得到2,4,6-octatrienyl palmitate
  参考文献：
  名称：

  [EN] POLYUNSATURATED LINEAR ALDEHYDES AND THEIR DERIVATIVES WITH ANTI-RADICAL AND ANTI-TUMORAL ACTIVITY
  [FR] ALDEHYDES LINEAIRES POLYINSATURES ET LEURS DERIVES A ACTIVITE ANTI-RADICALAIRE ET ANTI-TUMORALE

  摘要：

  本发明涉及从鹦鹉的羽毛或组织中提取或通过合成制备的多不饱和线性醛及其衍生物，具有抗氧化、抗肿瘤和抗炎活性，并可用于预防和治疗心血管、炎症、动脉粥样硬化、增生细胞和肿瘤损伤以及预防衰老引起的变化。

  公开号：

  WO2003095403A1

文献信息

• Polyunsaturated linear aldehydes and their derivatives with anti-radical and anti-tumoral activity
  申请人：Stradi Riccardo

  公开号：US20050175555A1

  公开（公告）日：2005-08-11

  The invention relates to polyunsaturated linear aldehydes and derivatives thereof which can be extracted from the feathers or tissues of parrots of prepared synthetically with antioxidant, antitumoral and anti-inflammatory activity, and which are useful in the prevention and treatment of cardiovascular, inflammatory, atherosclerotic, proliferative cell and tumour damage and the prevention of alterations caused by ageing.

  本发明涉及从鹦鹉的羽毛或组织中提取或合成的多不饱和线性醛及其衍生物，具有抗氧化、抗肿瘤和抗炎活性，可用于预防和治疗心血管、炎症性、动脉粥样硬化、增殖细胞和肿瘤损伤以及预防衰老引起的变化。
• DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
  申请人：Giuliani Giammaria

  公开号：US20110224298A1

  公开（公告）日：2011-09-15

  The present invention relates to a novel use of compounds having the general formula (I): CH 3 (—CH═CH) n —R  (I) where n=from 2 to 7, and R is chosen from among: CHO, CH 2 OH, CH 2 O—CO—R′, CO—OR′, CO—O (−) , where R′ is chosen from among H, the alkyl from C 1 to C 22 , each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.

  本发明涉及具有通式（I）的化合物的新用途： CH3（—CH═CH）n—R  (I) 其中n=2至7，R选择自：CHO，CH2OH，CH2O—CO—R′，CO—OR′，CO—O（−），其中R′选择自：H，C1至C22的烷基。每个通式（I）的化合物被用作活性原料，单独或混合使用，用于制备医药或化妆品组合物，通过细胞角蛋白cK-19介导的角蛋白的生产，提高人类表皮细胞修复活性。
• Compounds with a skin pigmenting activity and pharmaceutical or cosmetic compositions containing them
  申请人：Giuliani S.p.A.

  公开号：EP2407163A1

  公开（公告）日：2012-01-18

  The present invention relates to compounds having general formula (I):          CH3-(CH=CH)n-R     (I) where: n = 3, 5, 7; R is chosen from -CH2-O-CO-R', -CO-OR' or -CO-O(-), R' is chosen from H, C1-C22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.

  本发明涉及通式 (I) 的化合物： CH3-(CH=CH)n-R (I) 其中：n = 3、5、7；R 选自 -CH2-O-CO-R'、-CO-OR' 或 -CO-O(-)，R' 选自 H、C1-C22 烷基或烯基、芳基或芳烷基或糖； 及其药学上可接受的盐（如钠盐、钾盐和赖氨酸盐），用作药物或化妆品组合物中的活性成分，用于改善人体皮肤的色素沉着，治疗色素沉着疾病和/或改善皮肤的光保护能力及其晒黑的强度。
• POLYUNSATURATED LINEAR ALDEHYDES AND THEIR DERIVATIVES WITH ANTI-RADICAL AND ANTI-TUMORAL ACTIVITY
  申请人：UNIVERSITA'DEGLI STUDI DI MILANO

  公开号：EP1501774A1

  公开（公告）日：2005-02-02
• POLYUNSATURATED LINEAR ALDEHYDES AND THEIR DERIVATIVES WITH ANTI-RADICAL ACTIVITY
  申请人：Giuliani S.p.A.

  公开号：EP1501774B1

  公开（公告）日：2009-08-12