环己烷-1,2,3-三羧酸 | 141805-83-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 环己烷-1,2,3-三羧酸
• 英文名称: cyclohexane-1,2,3-tricarboxylic acid
• CAS: 141805-83-6
• 化学式: C₉H₁₂O₆
• 分子量: 216.191
• InChiKey: JEBXNNPMFYXVHS-UHFFFAOYSA-N

物化性质

• 沸点：
  470.1±45.0 °C(Predicted)
• 密度：
  1.509±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  环己烷-1,2,3-三羧酸 在 n-butylsilane 、 三(五氟苯基)硼烷 作用下， 以 二氯甲烷 为溶剂， 以52%的产率得到1,2,3-三甲基环己烷
  参考文献：
  名称：

  A novel reduction of polycarboxylic acids into their corresponding alkanes using n-butylsilane or diethylsilane as the reducing agent

  摘要：

  A convenient one-pot reaction has been developed for the reduction of polycarboxylic acids on aliphatic and aromatic systems to their corresponding alkanes. The reduction utilises either diethylsilane or n-butylsilane as the reducing agent in the presence of the Lewis acid catalyst tris(pentafluorophenyl)borane. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.03.111

文献信息

• AZIRIDINATED TRIGLYCERIDES AND POLYMERS FORMED THEREFROM
  申请人：Iowa State University Research Foundation, Inc.

  公开号：US20160289218A1

  公开（公告）日：2016-10-06

  Various embodiments disclosed relate to aziridinated triglycerides and polymers formed therefrom. In various embodiments, the present invention provides an aziridinated triglyceride having the structure described herein. In various embodiments, the present invention provides a method of making the aziridinated triglyceride, a method of crosslinking the aziridinated triglyceride to form a polymer, the polymer formed from the aziridinated triglyceride, a triglyceride with at least one pendent unsaturated group that can be used to form the aziridinated triglyceride, and a method of making the triglyceride having at least one pendent unsaturated group.

  各种实施方式涉及到环氧化三酸甘油和由此形成的聚合物。在各种实施方式中，本发明提供了一种具有此处描述的结构的环氧化三酸甘油。在各种实施方式中，本发明提供了一种制备环氧化三酸甘油的方法，一种交联环氧化三酸甘油以形成聚合物的方法，由环氧化三酸甘油形成的聚合物，一种具有至少一个可用于形成环氧化三酸甘油的侧链不饱和基团的三酸甘油，以及一种制备具有至少一个侧链不饱和基团的三酸甘油的方法。
• [EN] PHARMACEUTICAL COMPOSITIONS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES
  申请人：GENZYME CORP

  公开号：WO2009154747A1

  公开（公告）日：2009-12-23

  This invention relates to crosslinked amine-containing polymers for binding compounds or ions, and more specifically relates to pharmaceutically acceptable compositions for binding compounds or ions that include crosslinked amine-containing polymers. The pharmaceutically acceptable composition includes, for example, crosslinked polyamine particles, or pharmaceutically acceptable salts thereof, having a particle size distribution wherein greater than 10 vol.% of the particles have a particle size greater than 500 μm.

  这项发明涉及交联胺含有聚合物用于结合化合物或离子，更具体地涉及用于结合化合物或离子的药用可接受组合物，其中包括交联胺含有聚合物。药用可接受组合物包括例如交联聚胺颗粒或其药用可接受盐，具有粒径分布，其中大于10体积%的颗粒具有大于500μm的粒径。
• Method of preparing cyclohexanepolycarboxylic acid ester without phthalatic and plasticizer prepared by the same
  申请人：Shieh Sung-Yueh

  公开号：US20080183004A1

  公开（公告）日：2008-07-31

  A method for preparing a kind of plasticizer containing cyclohexane poly carboxylic acid ester, particularly without phthalate, and with the advantage of effective shortening of reaction time, which method comprising having cyclohexane polycarboxylic acid or its derivatives, mono-alcohol and metal catalyst of tin and titanium or inorganic acid added together at the same time into a reactor to undergo a single stage of esterification at high temperature of 200˜250° C., and a reaction mixture of cyclohexane polycarboxylic acid ester was obtained by the process which is applicably used as a plasticizer without phthalate and no hazard to the living beings and environment.

  一种制备不含邻苯二甲酸酯的环己烷聚羧酸酯类增塑剂的方法，具有有效缩短反应时间的优点，该方法包括将环己烷聚羧酸或其衍生物、单醇和锡和钛金属催化剂或无机酸同时加入反应釜中，在高温（200~250°C）下进行单阶酯化反应，通过该过程获得环己烷聚羧酸酯的反应混合物，该混合物可作为一种不含邻苯二甲酸酯的增塑剂，对生物和环境无危害。
• Method of preparing cyclohexanepolycarobxylic acid ester without phthalatic and plasticizer prepared by the same
  申请人：NAN YA PLASTICS CORPORATION

  公开号：EP1953135A1

  公开（公告）日：2008-08-06

  A method for preparing a kind of plasticizer containing cyclohexane poly carboxylic acid ester, particularly without phthalate, and with the advantage of effective shortening of reaction time, which method comprising having cyclohexane polycarboxylic acid or its derivatives, mono-alcohol and metal catalyst of tin and titanium or inorganic acid added together at the same time into a reactor to undergo a single stage of esterification at high temperature of 200~250°C, and a reaction mixture of cyclohexane polycarboxylic acid ester was obtained by the process which is applicably used as a plasticizer without phthalate and no hazard to the living beings and environment.

  一种制备一种含环己烷聚羧酸酯类的增塑剂的方法，特别是不含邻苯二甲酸酯类，具有有效缩短反应时间的优点。该方法包括将环己烷聚羧酸或其衍生物、单醇和锡和钛金属催化剂或无机酸同时加入反应釜中，在高温（200~250°C）下进行单阶酯化反应，通过该过程得到一种环己烷聚羧酸酯的反应混合物，该混合物可作为一种无邻苯二甲酸酯增塑剂，对生物和环境无危害。
• Process for producing esterificated condensate
  申请人：——

  公开号：US20040015005A1

  公开（公告）日：2004-01-22

  The present invention provides a method for preparing ester or thioester that can conduct catalytic esterification reaction with an equimolar amount of carboxylic acid and alcohol, or catalytic thioesterification reaction with carboxylic acid and an equimolar amount or small amount of thiol, and can be expected as an industrial method that needs an enormous amount of synthesis in the light of green chemistry. By using hafnium chloride (IV), especially tetravalent hafnium compounds represented by hafnium chloride (IV)•(THF) 2 or hafnium (IV)t-butoxide as a (poly) condensation catalyst, direct condensation reaction is conducted from carboxylic acid and an equimolar amount of alcohol or a little smaller amount of thiol, in the nonpolar solvent such as toluene and the like, in a deoxidization atmosphere and under heating reflux, and the reaction synthesizes ester monomer or thioester monomer, polyester or polythioester. When heating reflux is conducted by using a nonpolar solvent, it is preferable to remove azeotropic water from the reaction system.

  本发明提供了一种制备酯或硫酯的方法，该方法可以与等摩尔量的羧酸和醇进行催化酯化反应，或者与羧酸和等摩尔量或少量硫醇进行催化硫酯化反应，可望作为一种需要大量合成的工业方法，符合绿色化学的原则。通过使用四氯化铪（IV），特别是以四氯化铪（IV）•（THF）2或四氯化铪（IV）t-丁氧基表示的四价铪化合物作为（聚）缩聚催化剂，可以从羧酸和等摩尔量的醇或稍微较少量的硫醇，在非极性溶剂如甲苯等中，在脱氧环境和加热回流下进行直接缩聚反应，合成酯单体或硫酯单体，聚酯或聚硫酯。当使用非极性溶剂进行加热回流时，最好从反应系统中去除共沸水。