1-Benzyl-3-carbethoxy-4-hydroxy-pyrrolidin | 788-21-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Benzyl-3-carbethoxy-4-hydroxy-pyrrolidin
• 英文别名: 3-hydroxy-4-ethyloxycarbonyl-1-phenylmethyl pyrrolidine；1-benzyl-3-ethoxycarbonyl-4-oxypyrrolidine；1-benzyl-4-hydroxy-pyrrolidine-3-carboxylic acid ethyl ester；ethyl 1-benzyl-4-hydroxypyrrolidine-3-carboxylate
• CAS: 788-21-6
• 化学式: C₁₄H₁₉NO₃
• 分子量: 249.31
• InChiKey: XWRMKUKCNUYSIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Benzyl-3-carbethoxy-4-hydroxy-pyrrolidin 在 盐酸 、 sodium borohydrid 作用下， 以 甲醇 为溶剂， 生成 1-Benzyl-3-hydroxymethyl-4-hydroxy-pyrrolidin
  参考文献：
  名称：

  Antimicrobial 1-thienyl-4-oxoquinoline-3-carboxylic acids

  摘要：

  1-噻吩基-4-氧喹啉-3-羧酸类化合物的分子式为##STR1##，其中R.sup.1为氨基(低)烷基，R.sup.2为噻吩基，X为卤原子，以及其药学上可接受的盐，所述化合物具有优异的抗微生物活性，因此可用作抗微生物剂，以及包含所述1-噻吩基-4-氧喹啉-3-羧酸类化合物或其药学上可接受的盐作为活性成分的药物组合物，与药学上可接受的稀释剂或载体混合。

  公开号：

  US04786649A1

文献信息

• 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial
  申请人：Bristol-Myers Company

  公开号：US04954507A1

  公开（公告）日：1990-09-04

  There are disclosed new naphthyridine- and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in warm-blooded animals. Also disclosed are novel amines and intermediates used in the preparation of the naphthyridine- and quinoline-carboxylic acids.

  公开了具有1-叔烷基取代基的新型萘啶酸和喹啉羧酸，含有它们的组合物，以及它们在治疗温血动物细菌感染中的用途。还公开了用于制备这些萘啶酸和喹啉羧酸的新颖胺和中间体。
• [EN] METHOD FOR PREPARING 3-HYDROXY-4-HYDROXYMETHYL-PYRROLIDINE COMPOUNDS<br/>[FR] PROCEDE DE PREPARATION DE COMPOSES DE 3-HYDROXY-4-HYDROXYMETHYL-PYRROLIDINE
  申请人：IND RES LTD

  公开号：WO2005033076A1

  公开（公告）日：2005-04-14

  This invention relates to a method of preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, a key intermediate compound for the synthesis of certain inhibitor compounds, including the step of enzyme catalysed enantioselective esterification of an hydroxy group of an hydroxypyrrolidine. The invention further relates to a method for preparing (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, which is the enantiomer of (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine.

  这项发明涉及一种制备(3R,4R)-3-羟基-4-羟甲基吡咯烷的方法，这是合成某些抑制剂化合物的关键中间体化合物，包括酶催化的对羟基吡咯烷的对映选择性酯化步骤。该发明还涉及一种制备(3S,4S)-3-羟基-4-羟甲基吡咯烷的方法，这是(3R,4R)-3-羟基-4-羟甲基吡咯烷的对映体。
• Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives
  申请人：Bristol-Myers Company

  公开号：US04965273A1

  公开（公告）日：1990-10-23

  There are disclosed new naphthyridine- and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in warm-blooded animals. Also disclosed are novel amines and intermediates used in the preparation of the naphthyridine- and quinoline-carboxylic acids.

  本发明公开了具有1-三级烷基取代基的新萘啶和喹啉羧酸，包含它们的组合物以及它们在治疗温血动物的细菌感染中的应用。还公开了用于制备萘啶和喹啉羧酸的新型胺和中间体。
• Antimicrobial 1-thienyl-4-oxoquinoline-3-carboxylix acid compounds
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0228035A2

  公开（公告）日：1987-07-08

  Novel 1-thienyl-4-oxoquinoline-3-carboxylic acid compounds of the formula: wherein R' is an amino (lower) alkyl, R2 is thienyl, and X is a halogen atom, and a pharmaceutically acceptable salt thereof, said compounds having excellent antimicrobial activity and hence being useful as an antimicrobial agent, and a pharmaceutical composition comprising as an active ingredient said 1-thienyl-4-oxoquinoline-3-carboxylic acid compounds or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable diluent or carrier.

  式中的新型 1-噻吩基-4-氧代喹啉-3-羧酸化合物： 其中 R' 为氨基（低级）烷基，R2 为噻吩基，X 为卤素原子，以及其药学上可接受的盐，所述化合物具有优异的抗菌活性，因此可用作抗菌剂，以及一种药物组合物，其活性成分包括所述 1-噻吩基-4-氧代喹啉-3-羧酸化合物或其药学上可接受的盐，并与药学上可接受的稀释剂或载体混合。
• 1-Tert-alkyl-substituted naphthyridine and quinoline carboxylic acids as antibacterial agents
  申请人：Bristol-Myers Squibb Company

  公开号：EP0266576A2

  公开（公告）日：1988-05-11

  There are disclosed new naphthyridine-and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in warm-blooded animals. Also disclosed are novel amines and intermediates used in the preparation of the naphthyridine-and quinoline-carboxylic acids.

  本发明公开了具有 1-叔烷基取代基的新型萘啶酸和喹啉羧酸、含有它们的组合物以及它们在治疗温血动物细菌感染中的用途。此外，还公开了用于制备萘啶和喹啉羧酸的新型胺和中间体。