2-氟-2-苯氧基乙酸 | 74590-70-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氟-2-苯氧基乙酸
• 英文名称: 2-fluoro-2-phenoxyacetic acid
• CAS: 74590-70-8
• 化学式: C₈H₇FO₃
• 分子量: 170.14
• InChiKey: HEXSLVTZXWZKHY-UHFFFAOYSA-N

物化性质

• 熔点：
  61-63 °C(Solv: heptane (142-82-5))
• 沸点：
  274.2±20.0 °C(Predicted)
• 密度：
  1.304±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氟-2-苯氧基乙酸 在 sodium hydroxide 、 Selectfluor 作用下， 以 水 为溶剂， 反应 2.58h， 以25%的产率得到二氟甲氧基苯
  参考文献：
  名称：

  Photo-fluorodecarboxylation of 2-Aryloxy and 2-Aryl Carboxylic Acids

  摘要：

  DOI：

  10.1002/anie.201206352
• 作为产物：
  描述：

  苯氧乙酸 在 三氟甲基次氟酸酯 、 水 、 lithium diisopropyl amide 作用下， 生成 2-氟-2-苯氧基乙酸
  参考文献：
  名称：

  .alpha.-Fluorination of carbonyl compounds with trifluoromethyl hypofluorite

  摘要：

  DOI：

  10.1021/ja00534a053

文献信息

• Novel heteroaryl substituted piperidine derivatives which are L-CPT1 inhibitors
  申请人：Ackermann Jean

  公开号：US20070129544A1

  公开（公告）日：2007-06-07

  The invention is concerned with novel substituted piperidine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and X are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.

  这项发明涉及式(I)的新型替代哌啶衍生物，其中R1、R2、R3、R4、R5、R6、R7和X的定义如说明书和权利要求中所述，以及其生理上可接受的盐和酯。这些化合物抑制L-CPT1，可用作药物。
• [EN] FLUORINATION PROCESS<br/>[FR] PROCÉDÉ DE FLUORATION
  申请人：UNIV OXFORD INNOVATION LTD

  公开号：WO2016151295A1

  公开（公告）日：2016-09-29

  The present invention relates to a process for producing an organic compound comprising an 18F atom, which process comprises treating a precursor organic compound comprising a –CY2X group with: (i) [18F] fluoride; and (ii) an activator which comprises a compound comprising silver, gold, copper or platinum, or which comprises elemental silver, gold, copper or platinum wherein: X is a leaving group; and each Y is independently selected from F, Cl, Br and H. Also described is the use of an activator which comprises a compound comprising silver, gold, copper or platinum, or which comprises elemental silver, gold, copper or platinum, in a process for producing an organic compound comprising an F atom according to the invention. A kit, composition and compound are also described.

  本发明涉及一种制备含有18F原子的有机化合物的方法，该方法包括用以下物质处理含有–CY2X基团的前体有机化合物：(i) [18F]氟化物；和(ii) 包括银、金、铜或铂化合物的活化剂，或包括元素银、金、铜或铂的活化剂，其中：X是一个离去基团；每个Y独立地选择自F、Cl、Br和H。还描述了使用包括银、金、铜或铂化合物的活化剂，或包括元素银、金、铜或铂的活化剂，按照本发明制备含有F原子的有机化合物的方法。同时还描述了一种试剂盒、组合物和化合物。
• DNA AND VECTOR FOR REGULATING THE EXPRESSION OF LACHRYMATOR SYNTHASE GENE, METHOD OF REGULATING THE EXPRESSION OF LACHRYMATOR SYNTHASE GENE USING THE SAME, AND PLANT WITH THE REGULATED EXPRESSION OF LACHRYMATOR SYNTHASE GENE
  申请人：House Foods Corporation

  公开号：EP1489181A1

  公开（公告）日：2004-12-22

  The object of the present invention is to provide DNA and RNA designed on the basis of the sequence of an enzyme gene for repressing the expression of the enzyme gene generating a lachrymatory factor from a precursor of the lachrymatory factor, and also a vector required for introducing DNA for repressing the expression of the gene of the lachrymatory factor-producing enzyme into a vegetable. The present invention relates to DNA comprising at least one sequence selected from the following sequences and a regulatory sequence connected to said sequence so as to make the transcription possible: (a) a DNA sequence encoding a protein or a polypeptide of a lachrymatory factor-producing enzyme or a part of the DNA sequence in a sense orientation, an antisense orientation or both the orientations, wherein the protein or the polypeptide has an effect of converting 1-propenylsulfenic acid into the lachrymatory factor; (b) a regulatory sequence of a DNA in a vegetable genome determined on the basis of the DNA encoding the protein or the polypeptide of the lachrymatory factor-producing enzyme or a part of the regulatory sequence in a sense orientation, an antisense orientation or both the orientations; and (c) a DNA sequence located between the DNA encoding the protein or the polypeptide of the lachrymatory factor-producing enzyme and the regulatory sequence of the DNA in the vegetable genome DNA determined on the basis of the DNA encoding the protein or the polypeptide of the lachrymatory factor-producing enzyme or a part of the DNA sequence in a sense orientation, an antisense orientation or both the orientations.

  本发明的目的是提供根据酶基因序列设计的DNA和RNA，用于抑制从催泪因子的前体产生催泪因子的酶基因的表达，还提供一种载体，用于将抑制催泪因子产生酶基因表达的DNA导入蔬菜中。本发明涉及 DNA，该 DNA 包含至少一个选自下列序列的序列和 与所述序列连接以实现转录的调控序列： (a) 编码产生催泪因子的酶的蛋白质或多肽的 DNA 序列，或编码该 DNA 序列的一部分的有义方向、反义方向或两个方向，其中该蛋白质或多肽具有将 1-丙烯基亚硫酸转化为催泪因子的作用； (b) 蔬菜基因组中 DNA 的调控序列，该序列是根据编码产生催泪因子酶的蛋白质或多肽的 DNA 或该调控序列的一部分的有义取向、反义取向或两个取向确定的；以及 (c) 位于蔬菜基因组 DNA 中编码该蛋白质或催泪因子产生酶的多肽的 DNA 与 DNA 的调控序列之间的 DNA 序列，该 DNA 序列是根据编码该蛋白质或催泪因子产生酶的多肽的 DNA 或该 DNA 序列的一部分按有义方向、反义方向或两种方向确定的。
• MIDDLETON W. J.; BINGHAM E. M., J. AMER. CHEM. SOC., 1980, 102, NO 14, 4845-4846
  作者：MIDDLETON W. J.、 BINGHAM E. M.

  DOI：——

  日期：——
• SURFACTANT BLENDS USEFUL IN AGRICULTURE
  申请人：Akzo Nobel Chemicals International B.V.

  公开号：EP2317846B1

  公开（公告）日：2018-03-21