(Z)-methyl 3-(4-amino-2,3,5,6-tetramethylphenyl)-3-(4-methylphenyl)but-2-en-3-one | 1041644-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-methyl 3-(4-amino-2,3,5,6-tetramethylphenyl)-3-(4-methylphenyl)but-2-en-3-one
• 英文别名: (z)-4-(4-Amino-2,3,5,6-tetramethylphenyl)-4-(4-methylphenyl)but-3-en-2-one；(Z)-4-(4-amino-2,3,5,6-tetramethylphenyl)-4-(4-methylphenyl)but-3-en-2-one
• CAS: 1041644-13-6
• 化学式: C₂₁H₂₅NO
• 分子量: 307.436
• InChiKey: WLCWPWYMYWNCDR-ODLFYWEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(p-tolyl)but-3-yn-2-one 、 2,3,5,6-四甲基苯胺 在 氟磺酸 作用下， 以31%的产率得到(Z)-methyl 3-(4-amino-2,3,5,6-tetramethylphenyl)-3-(4-methylphenyl)but-2-en-3-one
  参考文献：
  名称：

  Alkenylation of arylamines and N-arylacetamides with acetylene compounds in superacids

  摘要：

  Vinyl type cations generated in superacid HSO3F by the protonation of the triple bond of acetylene compounds efficiently react with arylammonium ions and N-arylacetamides yielding alkenylation products of the aromatic rings in the given amino derivatives. The regio- and stereoselectivity of electrophilic aromatic substitution was investigated involving vinyl type cations and arylammonium ions or N-arylacetamides in HSO3F.

  DOI：

  10.1134/s1070428008070063

文献信息

• Alkenylation of arylamines and N-arylacetamides with acetylene compounds in superacids
  作者：A. O. Shchukin、A. V. Vasil’ev、S. A. Aristov、G. K. Fukin、A. P. Rudenko

  DOI：10.1134/s1070428008070063

  日期：2008.7

  Vinyl type cations generated in superacid HSO3F by the protonation of the triple bond of acetylene compounds efficiently react with arylammonium ions and N-arylacetamides yielding alkenylation products of the aromatic rings in the given amino derivatives. The regio- and stereoselectivity of electrophilic aromatic substitution was investigated involving vinyl type cations and arylammonium ions or N-arylacetamides in HSO3F.