4-(2-hydroxyethyl)-thiosemicarbazide | 6926-55-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(2-hydroxyethyl)-thiosemicarbazide
• 英文别名: N-(2-hydroxyethyl)hydrazinecarbothioamide；4-(Hydroxyethyl)-thiosemicarbazide；4-(2-hydroxy-ethyl)-thiosemicarbazide；N-Amino-N'-<2-hydroxy-ethyl>-thioharnstoff；4-β-Hydroxyethyl-3-thiosemicarbazid；1-amino-3-(2-hydroxyethyl)thiourea
• CAS: 6926-55-2
• 化学式: C₃H₉N₃OS
• mdl: MFCD19201319
• 分子量: 135.19
• InChiKey: IQONCRYQQRHTQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  102
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二硫化碳 、 4-(2-hydroxyethyl)-thiosemicarbazide 以 N,N-二甲基甲酰胺 为溶剂， 生成 5-(2-hydroxy-ethylamino)-3H-[1,3,4]thiadiazole-2-thione
  参考文献：
  名称：

  Radioprotective action of thiadiazole derivatives

  摘要：

  DOI：

  10.1007/bf01156486
• 作为产物：
  描述：

  N-(2-hydroxyethyl)dithiocarbamic acid 在 sodium monochloroacetic acid 、 一水合肼 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 生成 4-(2-hydroxyethyl)-thiosemicarbazide
  参考文献：
  名称：

  微波辐射下无溶剂合成吲哚基缩氨基硫脲

  摘要：

  开发了一种快速、高效且环保的方法，用于在微波辅助无溶剂条件下以氧化铝为固体载体合成吲哚-3-甲醛缩氨基硫脲。与常规加热方法相比，该方法得到的目标产物收率良好。

  DOI：

  10.3184/030823410x12628833270368

文献信息

• Solvent-Free Synthesis of Indole-Based Thiosemicarbazones under Microwave Irradiation
  作者：Lingling Liu、Jie Yang、Zhigang Zhao、Peiyu Shi、Xingli Liu

  DOI：10.3184/030823410x12628833270368

  日期：2010.1

  A rapid, efficient and environmentally friendly methodology has been developed for the synthesis of indole-3-carboxaldehyde thiosemicarbazones by using aluminum oxide as the solid support under microwave assisted solvent-free conditions. Compared with the conventional heating method, this method gave the target products in good yield.

  开发了一种快速、高效且环保的方法，用于在微波辅助无溶剂条件下以氧化铝为固体载体合成吲哚-3-甲醛缩氨基硫脲。与常规加热方法相比，该方法得到的目标产物收率良好。
• The reaction of the periodate-oxidation products of 1,4-anhydroerythritol and of some related pyrrolidine glycols with thiosemicarbazides
  作者：V.C. Barry、Joan E. McCormick、R.S. McElhinney

  DOI：10.1016/s0008-6215(00)81203-3

  日期：1968.7

  Simple analogues of the dialdehyde formed by periodate oxidation of benzyl β- L -arabinopyranoside have been prepared. Oxydiacetaldehyde may be condensed with one or two moles of substituted thiosemicarbazides, whereas N -aryliminodiacetaldehydes give only bis(thiosemicarbazones). The oxidation of N -arylpyrrolidine-3,4-diols with one equivalent of periodate is straightforward if electron-attracting aromatic

  摘要制备了由高碘酸氧化苄基β-L-阿拉伯吡喃果糖苷形成的二醛的简单类似物。氧二乙醛可以与一或两摩尔取代的硫代氨基脲缩合，而N-芳基二乙醛仅给出双（硫代氨基脲）。如果存在吸引电子的芳族取代基，则用一当量的高碘酸盐氧化N-芳基吡咯烷-3,4-二醇很简单，但否则，可以证明吡咯烷环中NC键的某些裂解。分离出结晶的半结晶的2，6-二羟基-4-苯基吗啉。已经比较了一些α-官能取代的硫代半脲酮向乙二醛衍生物的转化率。
• Derivatives of thiocarbamic acid. Part I. Preparation of 4-substituted thiosemicarbazides
  作者：R. S. McElhinney

  DOI：10.1039/j39660000950

  日期：——

  A general reaction of primary and secondary amines with dithiocarbazate esters is described. These esters are convenient intermediates towards thiosemicarbazies. The 4-(β-dimethylaminoethyl) compound has been obtained from the isothiocyanate, of which some properties are recorded.

  描述了伯胺和仲胺与二硫代氨基甲酸酯的一般反应。这些酯是硫代氨基脲的方便中间体。由异硫氰酸酯获得了4-（β-二甲基氨基乙基）化合物，其一些性质已被记录。
• Cephem compounds
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04443443A1

  公开（公告）日：1984-04-17

  This invention relates to novel cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group; R.sup.2 is carboxy or a protected carboxy group; A is lower alkylene which may have an oxo group; R.sup.3 is carboxy, a protected carboxy group, lower alkyl, lower alkenyl, hydroxy (lower) alkyl, phenyl (lower) alkyl, phenyl, tolyl, xylyl, cumenyl, or naphthyl; and R.sup.4 is hydrogen or lower alkoxy, and pharmaceutically acceptable salts thereof.

  本发明涉及一种高抗微生物活性的新型头孢菌素化合物，其化学式为：##STR1##其中，R^1是氨基或保护氨基基团；R^2是羧基或保护羧基基团；A是较低的烷基，可能具有氧代基；R^3是羧基、保护羧基基团、较低的烷基、较低的烯基、羟基（较低的）烷基、苯基（较低的）烷基、苯基、甲苯基、二甲苯基、叔丁基或萘基；R^4是氢或较低的烷氧基，并且其药物学上可接受的盐。
• 3-Thiovinyl-cephalosporins
  申请人：Rhone-Poulenc Industries

  公开号：US04307116A1

  公开（公告）日：1981-12-22

  Novel cephalosporins of the general formula (I); ##STR1## in which R is alkyl, L-2-amino-2-carboxy-ethyl, phenyl, pyridyl, pyridyl-N-oxide, pyrimidin-2-yl, substituted pyridazin-3-yl, 5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazin-3-yl substituted in the 4-position, 1,3,4-triazol-5-yl or 2-alkoxycarbonyl-1,3,4-triazol-5-yl substituted in the 1-position, 1,4-dialkyl-5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazin-3-yl, 1-alkyl-5,6-dioxo-1,4,5,6-tetrahydro-1,2,4-triazin-3-yl, 2-alkyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl, triazol-5-yl, 1,3,4-thiadiazol-5-yl which is substituted or unsubstituted, 1,2,4-thiadiazol-5-yl which is substituted, 1,3,4-oxadiazol-5-yl which is substituted or unsubstituted, oxazol-2-yl which is substituted or unsubstituted or tetrazol-5-yl which is substituted or unsubstituted in the 1-position, R' is a hydrogen atom or a radical of the general formula (II); ##STR2## and R.sup.o is hydrogen, alkyl, vinyl or cyanomethyl, as well as their salts, are useful as anti-bacterial agents.

  通式(I)的新型头孢菌素；其中R为烷基，L-2-氨基-2-羧基乙基，苯基，吡啶基，吡啶-N-氧化物，嘧啶-2-基，取代的吡啶-3-基，4-位取代的5,6-二氧化-1,4,5,6-四氢-1,2,4-三嗪-3-基，1,3,4-三唑-5-基或1-位取代的2-烷氧羰基-1,3,4-三唑-5-基，1,4-二烷基-5,6-二氧化-1,4,5,6-四氢-1,2,4-三嗪-3-基，1-烷基-5,6-二氧化-1,4,5,6-四氢-1,2,4-三嗪-3-基，2-烷基-5,6-二氧化-1,2,5,6-四氢-1,2,4-三嗪-3-基，三唑-5-基，1,3,4-噻二唑-5-基，取代或未取代的1,2,4-噻二唑-5-基，取代或未取代的1,3,4-噁二唑-5-基，取代或未取代的噁唑-2-基或取代或未取代的1-位四唑-5-基，R'为氢原子或通式(II)的基团；其中R.sup.o为氢，烷基，乙烯基或氰甲基，以及它们的盐，可用作抗菌剂。