2'-amino-1,1'-biphenyl-4-ol | 65975-66-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-amino-1,1'-biphenyl-4-ol
• 英文别名: 2'-Amino-biphenyl-4-ol；2-amino-4'-hydroxybiphenyl；2'-aminobiphenyl-4-ol；4-(2-aminophenyl)phenol
• CAS: 65975-66-8
• 化学式: C₁₂H₁₁NO
• mdl: MFCD04117375
• 分子量: 185.225
• InChiKey: XEAJHRZJCLFCSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2'-amino-1,1'-biphenyl-4-ol 以 四氢呋喃 、 氯仿 为溶剂， 生成 2'-(sulfamoylamino)biphenyl-4-yl sulfamate
  参考文献：
  名称：

  PHENYL SULFAMATE DERIVATIVES

  摘要：

  公开号：

  EP1193250B1
• 作为产物：
  描述：

  N-(4'-hydroxy-biphenyl-2-yl)-acetamide 在 盐酸 、 溶剂黄146 作用下， 生成 2'-amino-1,1'-biphenyl-4-ol
  参考文献：
  名称：

  Synthesis of Heterocyclic Compounds from Aryl Azides. IV. Benzo-, Methoxy-, and Chloro-carbazoles^1,2

  摘要：

  DOI：

  10.1021/jo01098a006

文献信息

• A ruthenium-catalyzed free amine directed (5+1) annulation of anilines with olefins: diverse synthesis of phenanthridine derivatives
  作者：Deepan Chowdhury、Suman Dana、Anup Mandal、Mahiuddin Baidya

  DOI：10.1039/c9cc05717j

  日期：——

  annulation between 2-aminobiphenyls and activated olefins is disclosed for succinct synthesis of valuable phenanthridine scaffolds. The protocol avails a common organic functional group, free amine, as a directing group and represents a unique combination of C–H activation/annulation/C–C bond cleavage cascade that bodes well in the production of bioactive alkaloids including trisphaeridine and bicolorine

  公开了2-氨基联苯和活化的烯烃之间的钌（II）催化的交叉环（5 + 1）环化，用于简洁地合成有价值的菲啶骨架。该方案利用一个常见的有机官能团，即游离胺作为指导基团，代表了C–H活化/环化/ C–C键裂解级联的独特组合，预示着生物活性生物碱（包括三叶啶和双色氨酸）的产生。
• <i>N</i>-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling
  作者：Mei-Jung Lai、Hsueh-Yun Lee、Hsun-Yueh Chuang、Li-Hsun Chang、An-Chi Tsai、Mei-Chuan Chen、Han-Lin Huang、Yi-Wen Wu、Che-Ming Teng、Shiow-Lin Pan、Yi-Min Liu、Samir Mehndiratta、Jing-Ping Liou

  DOI：10.1021/acs.jmedchem.5b00659

  日期：2015.8.27

  series of N-sulfonyl-aminobiaryl derivatives have been examined as novel antitubulin agents. Compound 21 [N-(4′-cyano-3′-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonamide] exhibits remarkable antiproliferative activity against four cancer cell lines (pancreatic AsPC-1, lung A549, liver Hep3B, and prostate PC-3) with a mean GI50 value of 57.5 nM. Additional assays reveal that 21 inhibits not only tubulin

  一系列N-磺酰基-氨基联芳基衍生物已被检测为新型抗微管蛋白药物。化合物21 [ N -(4'-cyano-3'-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonamide] 对四种癌细胞系（胰腺 AsPC-1、肺 A549、肝 Hep3B、和前列腺 PC-3)，平均 GI 50值为 57.5 nM。其他测定显示21不仅抑制微管蛋白聚合，而且抑制 STAT3 抑制的磷酸化，IC 50值为 0.2 μM。四种其他化合物（8、10、19和35) 也能够抑制这种磷酸化。这项研究描述了新型N-磺酰基-氨基联芳基（联芳基-苯磺酰胺）作为靶向 STAT3 和微管蛋白的有效抗癌剂。
• Oxazole derivatives
  申请人：——

  公开号：US20040006116A1

  公开（公告）日：2004-01-08

  Compounds of formula I are provided 1 as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 8 and n have the significance given in the specification can be used to treat non-insulin dependent diabetes mellitus.

  提供了符合式I的化合物，以及其药用可接受的盐和酯，其中R1至R8和n的含义如规范中所述，可用于治疗非胰岛素依赖型糖尿病。
• Synthesis of phenanthridinones viapalladium-catalyzed C(sp²)–H aminocarbonylation of unprotected o-arylanilines
  作者：Dongdong Liang、Ziwei Hu、Jiangling Peng、Jinbo Huang、Qiang Zhu

  DOI：10.1039/c2cc36817j

  日期：——

  An efficient synthesis of free (NH)-phenanthridinones through Pd-catalyzed C(sp(2))-H aminocarbonylation of unprotected o-arylanilines under an atmospheric pressure of CO has been developed. Some ortho heteroarene substituted anilines as well as N-alkyl protected o-arylanilines are also suitable substrates for this C-H aminocarbonylation reaction.

  有效的合成游离（NH）-菲啶酮通过CO的大气压下未保护的邻芳基苯胺的Pd催化C（sp（2））-H氨基羰基化反应。一些邻杂芳基取代的苯胺以及N-烷基保护的邻芳基苯胺也是该CH氨基羰基化反应的合适底物。
• Acid halide and/or acyllactam functional compounds and polylactam block copolymers derived therefrom
  申请人：STAMICARBON B.V.

  公开号：EP0404255A1

  公开（公告）日：1990-12-27

  The invention relates to acid halide and/or acyllactam functional compounds, to polylactam block copolymers derived therefrom by lactam polymerization at a lactam group, and to the use of such block copolymers in polyamide mixtures. The compounds contain liquid crystalline compounds or compounds which combine with acyllactam to form a compound with liquid crystalline properties. The products of this invention are useful as accelerators in the preparation of nylon block copolymers, in particular block copolymers with improved stiffness. The block copolymers are useful in products requiring good tensile strength, chemical resistance and/or heat resistance, and are particularly useful in electrical engineering applications and in the aircraft industry.

  该发明涉及酸卤和/或酰乳酰胺功能化合物，以及由此类化合物通过在乳酰胺基团上进行乳酰聚合而衍生的聚乳酰块共聚物，以及在聚酰胺混合物中使用这种块共聚物。这些化合物含有液晶化合物或与酰乳酰胺结合形成具有液晶性能的化合物。该发明的产品可用作尼龙块共聚物制备中的催化剂，特别是改善了刚度的块共聚物。这些块共聚物适用于需要良好抗拉强度、化学抵抗力和/或耐热性的产品，尤其适用于电气工程应用和航空工业中。