(6'-Hydroxymethyl-4,6,2',4'-tetramethoxy-biphenyl-2-yl)-methanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (6'-Hydroxymethyl-4,6,2',4'-tetramethoxy-biphenyl-2-yl)-methanol
• 英文别名: [2-[2-(hydroxymethyl)-4,6-dimethoxyphenyl]-3,5-dimethoxyphenyl]methanol
• 化学式: C₁₈H₂₂O₆
• 分子量: 334.369
• InChiKey: PEOARMKVDWAVAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (6'-Hydroxymethyl-4,6,2',4'-tetramethoxy-biphenyl-2-yl)-methanol 在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以92%的产率得到rac-4,4',6,6'-tetramethoxy-1,1'-biphenyl-2,2'-dicarbaldehyde
  参考文献：
  名称：

  Atropo-Enantioselective Synthesis of the Natural Bicoumarin (+)-Isokotanin A via a Configurationally Stable Biaryl Lactone

  摘要：

  The atropo-enantioselective total synthesis of the axially chiral bicoumarin (+)-isokotanin A (1) is described. Key steps were the formation of a configurationally stable seven-membered biaryl lactone and its kinetic resolution by atroposelective ring cleavage, The previous assignment of the absolute configuration of (+)-isokotanin A (1) (and its synthetic precursors) was confirmed by quantum chemical CD calculations. (C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

  DOI：

  10.1002/1099-0690(200203)2002:6<1096::aid-ejoc1096>3.0.co;2-z
• 作为产物：
  描述：

  苯甲酸,2-溴-3,5-二甲氧基-,甲基酯 在 lithium aluminium tetrahydride 、 铜 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.0h， 生成 (6'-Hydroxymethyl-4,6,2',4'-tetramethoxy-biphenyl-2-yl)-methanol
  参考文献：
  名称：

  Atropo-Enantioselective Synthesis of the Natural Bicoumarin (+)-Isokotanin A via a Configurationally Stable Biaryl Lactone

  摘要：

  The atropo-enantioselective total synthesis of the axially chiral bicoumarin (+)-isokotanin A (1) is described. Key steps were the formation of a configurationally stable seven-membered biaryl lactone and its kinetic resolution by atroposelective ring cleavage, The previous assignment of the absolute configuration of (+)-isokotanin A (1) (and its synthetic precursors) was confirmed by quantum chemical CD calculations. (C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

  DOI：

  10.1002/1099-0690(200203)2002:6<1096::aid-ejoc1096>3.0.co;2-z

文献信息

• [EN] ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：GILEAD SCIENCES INC

  公开号：WO2010132601A1

  公开（公告）日：2010-11-18

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  这项发明涉及抗病毒化合物，含有这种化合物的组合物，包括给予这种化合物的治疗方法，以及用于制备这种化合物的过程和中间体。
• The first synthesis of optically pure (+)- and (−)-isokotanin A and the assignment of their absolute configuration
  作者：Guo-Qiang Lin、Min Zhong

  DOI：10.1016/0040-4039(96)00457-1

  日期：1996.4

  The first asymmetric synthesis of optically pure (+) and (−)-Isokotanin A is described. The key steps involve the asymmetric Ullmann coupling and selective demethylation. The absolute configuration of the naturally occuring (+)-Isokotanin A is assigned as aR.

  描述了光学纯的（+）和（-）-异黄酮A的第一不对称合成。关键步骤涉及不对称的乌尔曼偶合和选择性脱甲基。在天然存在的（+）的绝对构型- Isokotanin A被指定为[R 。
• ANTIVIRAL COMPOUNDS
  申请人：Guo Hongyan

  公开号：US20120157404A1

  公开（公告）日：2012-06-21

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  该发明涉及抗病毒化合物、含有这些化合物的组合物以及包括给予这些化合物的治疗方法，还涉及用于制备这些化合物的过程和中间体。
• Antiviral compounds
  申请人：Gilead Sciences, Inc.

  公开号：US08273341B2

  公开（公告）日：2012-09-25

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  该发明涉及抗病毒化合物，含有这种化合物的组合物以及包括该化合物的给药的治疗方法，以及用于制备这种化合物的过程和中间体。
• Bringmann, Gerhard; Pfeifer, Robert-Michael; Rummey, Christian, Zeitschrift fur Naturforschung, B: Chemical Sciences, 2003, vol. 58, # 2-3, p. 231 - 236
  作者：Bringmann, Gerhard、Pfeifer, Robert-Michael、Rummey, Christian、Pabst, Thomas、Leusser, Dirk、Stalke, Dietmar

  DOI：——

  日期：——