1-[2,3-di(tert-butoxycarbonyl)guanidino]-4-ethoxybenzene | 1344681-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[2,3-di(tert-butoxycarbonyl)guanidino]-4-ethoxybenzene
• 英文别名: 1-(4-ethoxyphenyl)-2,3-di(tert-butoxycarbonyl)guanidine；tert-butyl N-[N'-(4-ethoxyphenyl)-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]carbamate
• CAS: 1344681-31-7
• 化学式: C₁₉H₂₉N₃O₅
• 分子量: 379.456
• InChiKey: ZXAVMVIEUCTLLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  98.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[2,3-di(tert-butoxycarbonyl)guanidino]-4-ethoxybenzene 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Guanidine-based α2-adrenoceptor ligands: Towards selective antagonist activity

  摘要：

  Depression has been linked to a selective increase in the high affinity conformation of the alpha(2)-adrenergic autoreceptors (alpha 2-ARs) in the human brain as well as to an overexpression of alpha 2-ARs in the hippocampus and cerebral cortex. Thus, the development of novel alpha 2-AR antagonists represents an attractive source of new antidepressants. This paper describes the design, synthesis and pharmacological evaluation of 30 new guanidinium and 2-iminoimidazolidinium as potential alpha 2-AR antagonists. In order to design this new series of alpha 2-AR antagonists, a pharmacophore model was developed using the GALAHAD software. This study suggested that increased substitution in the space surrounding the cationic guanidine moiety might lead selectively to antagonist activity. Following the preparation of compounds incorporating this feature and competitive radioligand binding, [S-35]GTP gamma S functional assays revealed that this structural modification affords exclusively alpha 2-AR antagonists, in contrast with the analogous unsubstituted compounds in which a mixture of antagonist/agonist activities was previously observed. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.05.057
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 sodium hydride 、 三乙胺 、 copper dichloride 作用下， 以 四氢呋喃 、 二氯甲烷 、 mineral oil 为溶剂， 反应 5.5h， 生成 1-[2,3-di(tert-butoxycarbonyl)guanidino]-4-ethoxybenzene
  参考文献：
  名称：

  Copper(II) chloride promoted transformation of amines into guanidines and asymmetrical N,N′-disubstituted guanidines

  摘要：

  We present a concise, less-toxic and broadly applicable method for coupling weakly nucleophilic amines with N,N'-di-(tert-butoxycarbonyl)thiourea, N-(tert-butxoycarbonyl), N'-alkyl/arylsubstituted-thioureas and N,N'-di-(tert-butoxycarbonyl)imidazolidine-2-thione in the presence of copper(II) chloride. Subsequent removal of Boc protecting groups affords guanidines, di-substituted guanidines and 2-aminoimidazolines in modest to excellent overall yields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.070

文献信息

• Pyridin-2-yl Guanidine Derivatives: Conformational Control Induced by Intramolecular Hydrogen-Bonding Interactions
  作者：Brendan Kelly、Daniel H. O'Donovan、John O'Brien、Thomas McCabe、Fernando Blanco、Isabel Rozas

  DOI：10.1021/jo200954c

  日期：2011.11.18

  The synthesis and conformational analysis of a series of pyridin-2-yl guanidine derivatives using NMR, X-ray crystallography, and B3LYP/6-31+G** theoretical studies are reported. A remarkable difference was observed in the 1H NMR spectra of the guanidinium salts as compared with their N,N′-di-Boc protected and neutral analogues. This difference corresponds to a 180° change in the dihedral angle between

  据报道，使用NMR，X射线晶体学和B3LYP / 6-31 + G **理论研究了一系列吡啶-2-基胍衍生物的合成和构象分析。与胍盐的N，N相比，胍盐的1 H NMR光谱观察到显着差异。'-di-Boc保护的中性类似物。与Boc保护的衍生物相比，该差异对应于盐中胍/鎓部分与吡啶环之间的二面角变化180°，这一结论得到了理论研究，X射线数据和NMR的支持。分析。此外，我们的数据支持两个分子内氢键系统的存在：（i）盐中的吡啶N1原子和胍质子之间，以及（ii）Boc保护的衍生物的氨基甲酸叔丁酯基团内。为了验证观察到的构象控制是由这些分子内相互作用引起的，还制备和研究了一系列新的N -Boc - N'-丙基取代的吡啶-2-基胍。
• Copper(II) chloride promoted transformation of amines into guanidines and asymmetrical N,N′-disubstituted guanidines
  作者：Brendan Kelly、Isabel Rozas

  DOI：10.1016/j.tetlet.2013.05.070

  日期：2013.7

  We present a concise, less-toxic and broadly applicable method for coupling weakly nucleophilic amines with N,N'-di-(tert-butoxycarbonyl)thiourea, N-(tert-butxoycarbonyl), N'-alkyl/arylsubstituted-thioureas and N,N'-di-(tert-butoxycarbonyl)imidazolidine-2-thione in the presence of copper(II) chloride. Subsequent removal of Boc protecting groups affords guanidines, di-substituted guanidines and 2-aminoimidazolines in modest to excellent overall yields. (C) 2013 Elsevier Ltd. All rights reserved.
• Guanidine-based α2-adrenoceptor ligands: Towards selective antagonist activity
  作者：Daniel H. O'Donovan、Carolina Muguruza、Luis F. Callado、Isabel Rozas

  DOI：10.1016/j.ejmech.2014.05.057

  日期：2014.7

  Depression has been linked to a selective increase in the high affinity conformation of the alpha(2)-adrenergic autoreceptors (alpha 2-ARs) in the human brain as well as to an overexpression of alpha 2-ARs in the hippocampus and cerebral cortex. Thus, the development of novel alpha 2-AR antagonists represents an attractive source of new antidepressants. This paper describes the design, synthesis and pharmacological evaluation of 30 new guanidinium and 2-iminoimidazolidinium as potential alpha 2-AR antagonists. In order to design this new series of alpha 2-AR antagonists, a pharmacophore model was developed using the GALAHAD software. This study suggested that increased substitution in the space surrounding the cationic guanidine moiety might lead selectively to antagonist activity. Following the preparation of compounds incorporating this feature and competitive radioligand binding, [S-35]GTP gamma S functional assays revealed that this structural modification affords exclusively alpha 2-AR antagonists, in contrast with the analogous unsubstituted compounds in which a mixture of antagonist/agonist activities was previously observed. (C) 2014 Elsevier Masson SAS. All rights reserved.