4-undecylmorpholine | 46843-82-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-undecylmorpholine
• CAS: 46843-82-7
• 化学式: C₁₅H₃₁NO
• 分子量: 241.417
• InChiKey: LIQBMPCOZRQPQX-UHFFFAOYSA-N

物化性质

• 沸点：
  135-140 °C(Press: 3 Torr)
• 密度：
  0.878±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-undecylmorpholine 、 双氧水 以86%的产率得到
  参考文献：
  名称：

  DEVINSKY F.; JACKO I.; NAGY A.; KRASNEC L., CHEM. ZVESTI, 1978, 32, NO 1, 106-115

  摘要：

  DOI：
• 作为产物：
  描述：

  吗啉 、 1-氯十一烷 在 sodium carbonate 作用下， 反应 12.0h， 生成 4-undecylmorpholine
  参考文献：
  名称：

  Beger, J.; Meerbote, E., Journal fur praktische Chemie (Leipzig 1954), 1984, vol. 326, # 1, p. 12 - 22

  摘要：

  DOI：

文献信息

• Rhodium‐Catalysed Reductive Amination for the Synthesis of Tertiary Amines
  作者：Jonas Bianga、Niklas Kopplin、Jonas Hülsmann、Dieter Vogt、Thomas Seidensticker

  DOI：10.1002/adsc.202000746

  日期：2020.10.21

  A procedure for the synthesis of tertiary amines via reductive amination of aldehydes with molecular hydrogen as a reducing agent using homogeneous rhodium catalysis is presented. Using an amine to aldehyde ratio of 4/1 enabled the synthesis of tertiary amines from nine different aldehydes and nine different secondary amines with selectivities up to 99% and turnover frequencies (TOF) up to 7200 h−1

  提出了一种使用均相铑催化通过分子氢作为还原剂对醛类进行还原胺化反应合成叔胺的方法。使用胺/醛比率为4/1时，可以由9种不同的醛和9种不同的仲胺合成叔胺，其选择性高达99％，周转频率（TOF）高达7200 h -1... 反应显示出对醇和酯功能的高耐受性，从而允许形成多功能分子。另外，仲胺也可以通过该合成来制备。对于所有化合物，活性都是通过吸收氢气来确定的。为了增加该过程的可持续性和效率，已经成功地制定了剂量策略。使用确定的反应指标，可以化学计量使用醛和胺，而不会显着降低选择性。
• PROCESS FOR PRODUCTION OF BIS-QUATERNARY AMMONIUM SALT, AND NOVEL INTERMEDIATE
  申请人：Okamoto Kuniaki

  公开号：US20120130107A1

  公开（公告）日：2012-05-24

  Object To provide a method for producing a bis-quaternary ammonium salt efficiently and a novel synthetic intermediate thereof. Solution The present invention relates to a method for producing a bis-quaternary ammonium salt represented by a general formula [3] which comprises reacting a disulfonic acid ester represented by a general formula [1] (in the formula, definitions of two R 1 's and T are as described in claim 1 ) with a tertiary amine represented by a general formula [2] (in the formula, definitions of R 3 to R 5 are as described in claim 1 ), and a disulfonic acid ester represented by a general formula [1′] (in the formula, two R 16 's represent independently a halogen atom or a C1-C3 fluoroalkyl group, and two m's represent independently an integer of 1 to 5).

  提供一种高效生产双季铵盐和其新型合成中间体的方法。本发明涉及一种生产由通用式[3]表示的双季铵盐的方法，包括将由通用式[1]表示的二磺酸酯（在该式中，两个R1和T的定义如权利要求1中所述）与由通用式[2]表示的三级胺（在该式中，R3到R5的定义如权利要求1中所述）以及由通用式[1']表示的二磺酸酯（在该式中，两个R16独立表示卤原子或C1-C3氟烷基，两个m独立表示1至5的整数）反应。
• Homogeneous and Semi-Heterogeneous Magnetically Retrievable Bis-N-Heterocyclic Carbene Rhodium(I) Based Catalysts for Selective Hydroaminomethylation Reactions
  作者：Bishnu Dutta、Rony Schwarz、Suheir Omar、Suzana Natour、Raed Abu-Reziq

  DOI：10.1002/ejoc.201403526

  日期：2015.3

  reactivity and selectivity compared to catalysts containing bidentate phosphine or monodentate NHC ligands. A triethoxysilyl-functionalized bis-NHC ligand was immobilized on magnetic nanoparticles and then utilized to bind a rhodium catalyst. The resulting catalytic system was successfully employed in hydroaminomethylation reactions. The catalyst exhibited excellent reactivity, high selectivity, and was

  研究了铑的各种双-N-杂环卡宾（双-NHC）配合物的制备及其在乙烯基芳烃氢氨甲基化中的应用。测试了各种反应参数，如溶剂、温度和压力，并将优化的方案应用于各种乙烯基芳烃和胺，以良好的收率和对支化产物的高选择性提供相应的胺。与含有双齿膦或单齿 NHC 配体的催化剂相比，基于双 NHC 的催化剂表现出优异的反应性和选择性。三乙氧基甲硅烷基官能化的双 NHC 配体固定在磁性纳米粒子上，然后用于结合铑催化剂。所得催化体系成功用于加氢氨甲基化反应。
• NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF
  申请人：SU Zhengyu

  公开号：US20160039879A1

  公开（公告）日：2016-02-11

  The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.

  本发明涉及公式（I）的化合物或其药学上可接受的盐，其中符号如规范中定义；包括该化合物的制药组合物，一种用于治疗或预防病毒感染、炎症、干眼症、中枢神经系统疾病、心血管疾病、癌症、肥胖症、糖尿病、肌肉萎缩症和脱发的方法。
• Novel disulfonic acid ester as an additive for an electrolyte for a lithium secondary battery
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP2821395A2

  公开（公告）日：2015-01-07

  Object To provide a method for producing a bis-quaternary ammonium salt efficiently and a novel synthetic intermediate thereof. Solution The present invention relates to a method for producing a bis-quaternary ammonium salt represented by a general formula [3] which comprises reacting a disulfonic acid ester represented by a general formula [1] (in the formula, definitions of two R1's and T are as described in Claim 1) with a tertiary amine represented by a general formula [2] (in the formula, definitions of R3 to R5 are as described in Claim 1), and a novel disulfonic acid ester represented by a general formula [1'] (in the formula, two R16's represent independently a halogen atom or a C1-C3 fluoroalkyl group, and two m's represent independently an integer of 1 to 5) as an additive for an electrolyte for a lithium secondary battery.

  目的 提供一种高效生产双季铵盐的方法及其新型合成中间体。 本发明涉及一种生产通式[3]代表的双季铵盐的方法，该方法包括将通式[1]代表的二磺酸酯（式中，两个 R1 和 T 的定义如权利要求 1 所述）与通式[2]代表的叔胺（式中、R3至R5的定义如权利要求1所述），以及通式[1']代表的新型二磺酸酯（式中，两个R16独立地代表卤素原子或C1-C3氟烷基，两个m独立地代表1至5的整数），作为锂二次电池电解液的添加剂。