环己甲酸钾 | 25666-60-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 环己甲酸钾
• 英文名称: potassium 1-cyclohexyl methanoate
• 英文别名: potassium cyclohexanecarboxylate；potassium cyclohexylcarboxylate；Potassium cyclohexane carboxylate；Cyclohexancarbonsaeure-kaliumsalz；potassium;cyclohexanecarboxylate
• CAS: 25666-60-8
• 化学式: C₇H₁₁O₂*K
• 分子量: 166.261
• InChiKey: VFLADTURPGNKHV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.68
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2916209090

反应信息

• 作为反应物：
  描述：

  氯甲基乙醚 、 环己甲酸钾 以30%的产率得到
  参考文献：
  名称：

  NIYAZOV A. N.; KRASNOVA N. V.; VAXABOVA X. D.; BEREZHNOJ V. G.; PIRMEDOV +, IZV. AN TSSR. CEP. FIZ.-TEXN., XIM. I GEOL. N.,(1986) N 5, 67-72

  摘要：

  DOI：
• 作为产物：
  描述：

  环己甲酸 在 potassium hydroxide 作用下， 以 水 为溶剂， 反应 4.0h， 生成 环己甲酸钾
  参考文献：
  名称：

  NOVEL NUCLEATING AGENTS FOR POLYOLEFINS BASED ON METAL SALTS

  摘要：

  本文介绍了一种新型金属盐，可作为聚烯烃成核剂。本发明涉及通过将氢氧化钾与羧酸反应合成的这些盐，并进一步涉及在聚丙烯组合物中分散含有一种或多种所述金属盐的配方，以实现高结晶温度。

  公开号：

  US20120289632A1
• 作为试剂：
  描述：

  芴 、 环己醇 在 环己甲酸钾 、 镍 、 xylene 作用下， 生成 9-cyclohexylfluorene
  参考文献：
  名称：

  Notes - The Base-Catalyzed Alkylation of Flourene with Secondary Alcohols

  摘要：

  DOI：

  10.1021/jo01117a614

文献信息

• Convenient synthesis of amides, esters, and thioesters using 2,2'-oxalyldi(2,3-dihydro-3-oxobenzisosulfonazole).
  作者：Tokujiro KITAGAWA、Hiroko KURODA、Keiko IIDA、Miyuki ITO、Miwa NAKAMURA

  DOI：10.1248/cpb.37.3225

  日期：——

  Potassium salts (22) of various carboxylic acids readily react with 2, 2'-oxalyldi(2, 3-dihydro-3-oxobenzisosulfonazole) (17) to form the corresponding 2-acyl-2, 3-dihydro-3-oxobenzisosulfonazoles (24) as intermediates, which undergo aminolysis, alcoholysis, and thioalcoholysis to afforded amides (5), esters (6), and thioesters (7), respectively. These findings show that 17 can be conveniently used as a condensing agent for the synthesis of carboxylic acid derivatives (5, 6 or 7).

  各种羧酸的钾盐（22）容易与2, 2'-草酰二（2, 3-二氢-3-氧代苯并异磺酰胺）（17）反应，形成相应的2-酰基-2, 3-二氢-3-氧代苯并异磺酰胺（24）作为中间体，这些中间体通过胺解、醇解和硫醇解分别得到酰胺（5）、酯（6）和硫酯（7）。这些发现表明，17可以方便地用作合成羧酸衍生物（5、6或7）的缩合剂。
• Ring-opening of hindered cyclic epoxides with potassium carboxylates in the presence of conjugate acids
  作者：John F. Trant、Tomas Hudlicky

  DOI：10.1139/cjc-2013-0386

  日期：2013.12

  During attempts to ring-open a highly hindered epoxide, traditional methods were found to be ineffective. An alternative strategy for opening epoxides was implemented that employed a potassium carboxylate in the presence of its conjugate acid in a solvent mixture containing polar and potassium-sequestering components. A systematic analysis of the components of the reaction mixture indicated that the addition of the conjugate acid was the most important feature for providing good conversion. This reaction appears to be general for most classes of carboxylic acids including cinnamic, aromatic, and highly hindered carboxylic acids (30%–79% yield) and only fails with weak carboxylate nucleophiles. Three highly substituted and hindered cyclohexene oxide derivatives were examined for reactivity and the reaction conditions appear to tolerate a variety of functional groups to provide the ring-opened species. This pH-moderate system proved useful for hindered cyclic epoxides when all other techniques failed and should prove general to a wide spectrum of epoxide and carboxylic acid partners in those cases where the use of a strong Lewis or protic acid catalyst, or a strong basic nucleophile, is inappropriate.

  在尝试开环一个高度阻碍的环氧化物时，发现传统方法无效。实施了一种替代策略来打开环氧化物，该策略利用了存在其共轭酸的钾羧酸盐，在含有极性和钾离子螯合成分的溶剂混合物中。对反应混合物组分的系统分析表明，添加共轭酸是提供良好转化的最重要特征。这种反应似乎适用于大多数类别的羧酸，包括肉桂酸、芳香族和高度阻碍的羧酸（30%–79% 收率），只有对弱羧酸亲核试剂失败。对三种高度取代和阻碍的环己烯氧化物衍生物进行了反应性检验，反应条件似乎能容忍各种官能团以提供开环物种。这种pH适中的体系在所有其他技术失败时对阻碍的环氧化物非常有用，并且在不适合使用强Lewis酸或质子酸催化剂，或强碱亲核试剂的情况下，应该适用于广泛的环氧化物和羧酸配体。
• The Hydroxide-Promoted Catalytic Hydrodefluorination of Fluorocarbons by Ruthenium in Aqueous Media
  作者：Michael M. Konnick、Steven M. Bischof、Roy A. Periana、Brian G. Hashiguchi

  DOI：10.1002/adsc.201200870

  日期：2013.3.11

  6‐imidizoylpyridine (IPI) in aqueous potassium hydroxide media is shown to be a suitable catalyst for the CF bond activation and subsequent hydrodefluorination (and hydrogenolysis) of a model fluorocarbon. Furthermore, the conversion of CF bonds was enhanced upon increasing the concentration of potassium hydroxide [KOH]. A simple, non‐ligated heterogeneous analogue derived from ruthenium(III) trichloride trihydrate

  由非质子无辜结扎络合物A钌配位体，氢氧化钾水溶液介质2,6- imidizoylpyridine（IPI）被示出为用于C的合适的催化剂模型氟碳的F键活化和随后加氢脱（和氢解）。此外，随着氢氧化钾[KOH]浓度的增加，CF键的转化率增加。一种简单的，未连接的，由三水合三氯化钌（III）溶解在氢氧化钾水溶液中形成的非均相类似物被证明是活性更高的催化剂，能够在室温下对芳基碳氢化合物进行加氢脱氟，并在更强的条件下对烷基碳氟化合物进行加氢脱氟。
• Persulfate‐Mediated Oxidative C−H Functionalization of Glycinates to Access Diverse Unnatural Amino Acids
  作者：Madala Hari Babu、Hyesu Jang、Miseon Han、Sang Kyum Kim、Jaehoon Sim

  DOI：10.1002/ejoc.202201259

  日期：2022.12.12

  Metal-free and an operationally simple radical-mediated reaction was developed to access diversified unnatural amino acids with alkyl carboxylic acids, H-phosphonates and H-phosphinates by using persulfate as the sole oxidizing agent. The overall reaction proceeds via oxidative generation of iminium ion from glycine derivatives followed by radical addition of alkyl and phosphonyl groups to yield α-alkyl

  通过使用过硫酸盐作为唯一的氧化剂，开发了一种无金属且操作简单的自由基介导反应，以通过烷基羧酸、H-膦酸盐和 H-次膦酸盐获得多样化的非天然氨基酸。整个反应通过甘氨酸衍生物氧化生成亚胺离子，然后烷基和膦酰基的自由基加成生成 α-烷基和 α-膦酰基甘氨酸衍生物。
• COMPOSITION AND METHOD FOR TEMPORARILY FIXING SOLID
  申请人：JSR Corporation

  公开号：EP1522567A1

  公开（公告）日：2005-04-13

  The present invention relates to a method of temporarily and firmly fixing two solids to each other and to a composition used in the method, which is a method of temporarily fixing, comprising temporarily fixing the two solids to each other with a liquid crystal compound or a composition comprising the liquid crystal compound. This method is used for a method of temporarily fixing a pad for chemical mechanical polishing, for example, to polish a wafer for a semiconductor device fixed on a surface of a base plate, when one solid is a pad for chemical mechanical polishing of a wafer for a semiconductor device and the other is a base plate to fix the pad.

  本发明涉及一种将两个固体暂时牢固地相互固定的方法以及用于该方法的组合物，该方法是一种暂时固定的方法，包括用液晶化合物或包含液晶化合物的组合物将两个固体暂时相互固定。该方法用于临时固定化学机械抛光垫的方法，例如，用于抛光固定在底板表面上的半导体器件晶片，其中一个固体是用于半导体器件晶片化学机械抛光的垫，另一个固体是用于固定垫的底板。