(R)-3,3'-dipyrid-4-yl-5,5',6,6'-tetramethyl-2,2'-dimethoxy-1,1'-biphenyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-3,3'-dipyrid-4-yl-5,5',6,6'-tetramethyl-2,2'-dimethoxy-1,1'-biphenyl
• 英文别名: 4-[2-Methoxy-3-(2-methoxy-5,6-dimethyl-3-pyridin-4-ylphenyl)-4,5-dimethylphenyl]pyridine；4-[2-methoxy-3-(2-methoxy-5,6-dimethyl-3-pyridin-4-ylphenyl)-4,5-dimethylphenyl]pyridine
• 化学式: C₂₈H₂₈N₂O₂
• 分子量: 424.543
• InChiKey: OJZLBJRVYFNQRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  六氟磷酸银 、 (R)-3,3'-dipyrid-4-yl-5,5',6,6'-tetramethyl-2,2'-dimethoxy-1,1'-biphenyl 以 甲醇 、 水 、 乙腈 为溶剂， 以81%的产率得到[Ag((R)-3,3'-bipyridine-5,5',6,6'-tetramethyl-2,2'-dimethoxy-1,1'-biphenyl)(PF6)1/6(OH)5/6]
  参考文献：
  名称：

  Anion-Driven Conformational Polymorphism in Homochiral Helical Coordination Polymers

  摘要：

  Three homochiral 3D frameworks are assembled based on periodically ordered arrays of helices built from axial chiral 3,3'-bipyridine-5,5',6,6'-tetramethyl-2,2'-dimethoxy-1,1'-biphenyl ligands and linearly coordinated Ag(l) ions. The aggregation behavior of silver salts and the ditopic ligand in solutions was investigated by a variety of techniques, including H-1 NMR, UV-vis, CD, GPC and MALDI-TOF. The cationic polymer skeleton exhibits an unprecedented conformational polymorphism in the solid-state, folding into two-, three- and four-fold helices with NO3-, PF6- and ClO4- as the counteranion, respectively. The twofold helices cross-link via argentophilic Ag-Ag interactions to form sextuple helices, which lead to a three-dimensional (3D) chiral framework. The three-fold or four-fold helices, on the other hand, self-associates in pairs to form three-dimensional tubular architectures. This anion-dependent self-assembly behavior can be rationalized by considering the sizes, geometries and binding abilities of the counteranions and subsequent chain conformation to minimize steric repulsions and maximize secondary interactions.

  DOI：

  10.1021/ja901154p
• 作为产物：
  描述：

  吡啶-4-硼酸 、 (S)-3,3'-dibromo-5,5',6,6'-tetramethyl-2,2'-dimethoxy-1,1'-biphenyl 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 sodium carbonate 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 24.0h， 以96%的产率得到(R)-3,3'-dipyrid-4-yl-5,5',6,6'-tetramethyl-2,2'-dimethoxy-1,1'-biphenyl
  参考文献：
  名称：

  Anion-Driven Conformational Polymorphism in Homochiral Helical Coordination Polymers

  摘要：

  Three homochiral 3D frameworks are assembled based on periodically ordered arrays of helices built from axial chiral 3,3'-bipyridine-5,5',6,6'-tetramethyl-2,2'-dimethoxy-1,1'-biphenyl ligands and linearly coordinated Ag(l) ions. The aggregation behavior of silver salts and the ditopic ligand in solutions was investigated by a variety of techniques, including H-1 NMR, UV-vis, CD, GPC and MALDI-TOF. The cationic polymer skeleton exhibits an unprecedented conformational polymorphism in the solid-state, folding into two-, three- and four-fold helices with NO3-, PF6- and ClO4- as the counteranion, respectively. The twofold helices cross-link via argentophilic Ag-Ag interactions to form sextuple helices, which lead to a three-dimensional (3D) chiral framework. The three-fold or four-fold helices, on the other hand, self-associates in pairs to form three-dimensional tubular architectures. This anion-dependent self-assembly behavior can be rationalized by considering the sizes, geometries and binding abilities of the counteranions and subsequent chain conformation to minimize steric repulsions and maximize secondary interactions.

  DOI：

  10.1021/ja901154p

文献信息

• Anion-Driven Conformational Polymorphism in Homochiral Helical Coordination Polymers
  作者：Guozan Yuan、Chengfeng Zhu、Yan Liu、Weimin Xuan、Yong Cui

  DOI：10.1021/ja901154p

  日期：2009.8.5

  Three homochiral 3D frameworks are assembled based on periodically ordered arrays of helices built from axial chiral 3,3'-bipyridine-5,5',6,6'-tetramethyl-2,2'-dimethoxy-1,1'-biphenyl ligands and linearly coordinated Ag(l) ions. The aggregation behavior of silver salts and the ditopic ligand in solutions was investigated by a variety of techniques, including H-1 NMR, UV-vis, CD, GPC and MALDI-TOF. The cationic polymer skeleton exhibits an unprecedented conformational polymorphism in the solid-state, folding into two-, three- and four-fold helices with NO3-, PF6- and ClO4- as the counteranion, respectively. The twofold helices cross-link via argentophilic Ag-Ag interactions to form sextuple helices, which lead to a three-dimensional (3D) chiral framework. The three-fold or four-fold helices, on the other hand, self-associates in pairs to form three-dimensional tubular architectures. This anion-dependent self-assembly behavior can be rationalized by considering the sizes, geometries and binding abilities of the counteranions and subsequent chain conformation to minimize steric repulsions and maximize secondary interactions.