9-ethyl-carbazol-3-yl isocyanate | 123591-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-ethyl-carbazol-3-yl isocyanate
• 英文别名: 9-Aethyl-carbazol-3-ylisocyanat；9-Ethyl-3-isocyanatocarbazole
• CAS: 123591-09-3
• 化学式: C₁₅H₁₂N₂O
• 分子量: 236.273
• InChiKey: HWXGKKOXNSMKSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  34.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9-ethyl-carbazol-3-yl isocyanate 生成 (9-ethyl-carbazol-3-yl)-carbamic acid methyl ester
  参考文献：
  名称：

  Siefken, Justus Liebigs Annalen der Chemie, 1949, vol. 562, p. 75,1114

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 COCl₂ 作用下， 生成 9-ethyl-carbazol-3-yl isocyanate
  参考文献：
  名称：

  Siefken, Justus Liebigs Annalen der Chemie, 1949, vol. 562, p. 75,1114

  摘要：

  DOI：

文献信息

• Direct positive silver halide photographic light-sensitive material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04719174A1

  公开（公告）日：1988-01-12

  A direct positive silver halide photographic light-sensitive material is described containing a weak electron donative, adsorptive compound represented by formula (I) or (II) effective for depressing formation of a re-reversed negative image, which is not a spectral sensitizing agent for silver halide or a nucleating agent: D--L--X (I) D--X (II) wherein D represents electron donative atoms comprising an aromatic ring or hereto ring, which is unsubstituted or substituted; L represents a linking group containing at least one of C, N, S and O and an atom or atoms necessary for cutting a .pi.-conjunction system; and X represents a group which is adsorptive with respect to silver halide and contains at least one of C, N, S, O and Se.

  描述了一种含有弱电子给体、吸附化合物的直接正像银卤片光敏材料，该化合物由式(I)或(II)表示，能够有效抑制反转负像的形成，该化合物不是银卤的光谱感光剂或成核剂：D--L--X (I) D--X (II) 其中，D代表电子给体原子，包括未取代或取代的芳香环或杂环；L代表包含至少一个C、N、S和O的连接基团以及必要的切断π-共轭系统的原子或原子；X代表对银卤吸附的基团，包含至少一个C、N、S、O和Se。
• Silver halide photographic light-sensitive material containing
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04607006A1

  公开（公告）日：1986-08-19

  A silver halide photographic light-sensitive material is described containing at least one electron-donative, silver halide-adsorptive compound represented by the following general formula (A) or (B), which is not a spectral sensitizing agent for silver halide or a nucleating agent: D--L--X (A) D--X (B) wherein D represents an electron donative atomic group comprising an aromatic ring or hetero ring, which may be unsubstituted or substituted with at least one substituent; L represents a linkage group containing at least one of C, N, S or O; and X represents a group which is adsorptive with a silver halide-adsorptive group containing at least one of C, N, S, O or Se, said N being optionally quarternized.

  本文描述了一种含有至少一种电子给予性、银卤化物吸附化合物的银卤化物感光材料，该化合物由下列通式（A）或（B）表示，不是银卤化物的光谱增感剂或成核剂：D--L--X（A）D--X（B）其中，D代表一个电子给予原子团，包括一个芳香环或杂环，可以是未取代或取代的，L代表一个包含至少一个C、N、S或O的连接基团，X代表一个与含有至少一个C、N、S、O或Se的银卤化物吸附基团吸附的基团，其中N可以选择进行季铵化。
• Synthesis and Structure−Activity Relationships of Trisubstituted Phenyl Urea Derivatives as Neuropeptide Y5 Receptor Antagonists
  作者：Christopher Fotsch、Jennifer D. Sonnenberg、Ning Chen、Clarence Hale、William Karbon、Mark H. Norman

  DOI：10.1021/jm0004547

  日期：2001.7.1

  1-((1R,2R)-2-Hydroxy-1-methyl-2-phenylethyl)-1-methyl-3-(4-phenoxyphenyl)urea (1) was identified as a hit from the screening of the neuropeptide Y5 (NPY5) receptor. This lead was optimized for in vitro potency by changing the stereochemistry, the phenylethyl segment, the urea portion, and the 4-phenoxyphenyl group on the molecule. Over 40 analogues of 1 were prepared to study the structure-activity relationship for this series. The most potent compounds in this class have IC(50)s less than 0.1 nM at the NPY5 receptor (e.g., 40f, 44a, and 47). To determine the functional activity for this series of compounds, selected analogues were tested in acellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor. All urea analogues tested in the functional assay acted as antagonists (e.g., 1, 32, 40a, and 44e).
• US3940246A
  申请人：——

  公开号：US3940246A

  公开（公告）日：1976-02-24
• US3994887A
  申请人：——

  公开号：US3994887A

  公开（公告）日：1976-11-30