2-氟-N-甲氧基-N-甲基-4-硝基苯甲酰胺 | 774239-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氟-N-甲氧基-N-甲基-4-硝基苯甲酰胺
• 英文名称: 2-fluoro-N-methoxy-N-methyl-4-nitrobenzamide
• 英文别名: N-Methoxy-N-methyl-4-nitro-2-fluorobenzamide
• CAS: 774239-17-7
• 化学式: C₉H₉FN₂O₄
• 分子量: 228.18
• InChiKey: CPNAYMYMDIQRLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  75.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-氟-N-甲氧基-N-甲基-4-硝基苯甲酰胺 在 铁粉 、 氯化铵 作用下， 以 甲醇 、 水 为溶剂， 反应 3.0h， 生成 4-氨基-2-氟-N-甲氧基-N-甲基苯甲酰胺
  参考文献：
  名称：

  HETEROCYCLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE

  摘要：

  公开号：

  EP1905769B1
• 作为产物：
  描述：

  2-氟-4-硝基苯甲酸 、 二甲羟胺盐酸盐 在 吡啶 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 反应 15.0h， 以85%的产率得到2-氟-N-甲氧基-N-甲基-4-硝基苯甲酰胺
  参考文献：
  名称：

  EP2202235

  摘要：

  公开号：

文献信息

• Hydrazone derivative
  申请人：Kawagoe Keiichi

  公开号：US20060276433A1

  公开（公告）日：2006-12-07

  A compound represented by the following formula (I): wherein R 1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R 2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R 3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof.

  以下是式子（I）所代表的化合物： 其中，R1代表氢、芳基（可能带有取代基）、饱和或不饱和的5-至7-成员杂环基（可能带有取代基）等； R2代表氢、芳基（可能带有取代基）、饱和或不饱和的5-至7-成员杂环基（可能带有取代基）等； R3代表氢等； Ar代表从芳香族碳氢化合物衍生的二价基团等； X代表单键、线性或支链烷基，具有1至3个碳原子，可能带有取代基等； G代表卤素、饱和或不饱和的5-或6-成员环烃基（可能带有取代基）、饱和或不饱和的5-至7-成员杂环基（可能带有取代基）等，其盐或溶剂化物；以及用于抑制淀粉样蛋白或类淀粉样蛋白的聚集和/或沉积的药剂，包括该化合物、其盐或溶剂化物。
• Bis(trimethylsilyl)phenyl compound or salt thereof, and use thereof
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：US07855300B2

  公开（公告）日：2010-12-21

  The present invention provides a compound that exhibits an excellent antitumor effect and reduces side effects, such as skin disorders, of the existing retinoid by selectively activating on the nuclear receptor RARα, thereby possibly producing significant improvement of clinical profits. Specifically, the present invention provides a bis(trimethylsilyl)phenyl compound represented by Formula (I): wherein X is N or CH; Y is O or S; R1, R2, and R3 are the same or different and are hydrogen or lower alkyl; R4 and R5 are the same or different and are hydrogen, lower alkyl, or halogen; and a bond between a carbon atom to which R1 is attached and a carbon atom to which R2 is attached is a single bond or a double bond; or a salt thereof.

  本发明提供了一种化合物，其表现出优异的抗肿瘤效果并减少现有维甲酸类药物的副作用，例如皮肤疾病，通过选择性激活核受体RARα，因此可能产生显著的临床利润改善。具体而言，本发明提供一种由式(I)表示的双(三甲基硅基)苯基化合物：其中X为N或CH；Y为O或S；R1、R2和R3相同或不同，为氢或低碳基；R4和R5相同或不同，为氢、低碳基或卤素；以及连接R1所附着的碳原子和R2所附着的碳原子之间的键为单键或双键；或其盐。
• BIS(TRIMETHYLSILYL)PHENYL COMPOUND OR SALT THEREOF, AND USE THEREOF
  申请人：Suda Yoshimitsu

  公开号：US20100210591A1

  公开（公告）日：2010-08-19

  The present invention provides a compound that exhibits an excellent antitumor effect and reduces side effects, such as skin disorders, of the existing retinoid by selectively activating on the nuclear receptor RARα, thereby possibly producing significant improvement of clinical profits. Specifically, the present invention provides a bis(trimethylsilyl)phenyl compound represented by Formula (I): wherein X is N or CH; Y is O or S; R1, R2, and R3 are the same or different and are hydrogen or lower alkyl; R4 and R5 are the same or different and are hydrogen, lower alkyl, or halogen; and a bond between a carbon atom to which R1 is attached and a carbon atom to which R2 is attached is a single bond or a double bond; or a salt thereof.

  本发明提供了一种化合物，该化合物通过选择性激活核受体RARα，展现出优异的抗肿瘤效果并减少现有维甲酸类药物的副作用，如皮肤疾病，从而可能显著提高临床效益。具体而言，本发明提供了一种由式（I）表示的双（三甲基硅基）苯基化合物：其中X是N或CH；Y是O或S；R1、R2和R3相同或不同，是氢或低碳基；R4和R5相同或不同，是氢、低碳基或卤素；以及连接R1和R2所连接的碳原子之间的键是单键或双键；或其盐。
• HYDRAZONE DERIVATIVE
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1612204A1

  公开（公告）日：2006-01-04

  A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof

  下式(I)所代表的化合物： 其中 R1 代表氢、可能具有取代基的芳基、可能具有取代基的饱和或不饱和 5 至 7 元杂环基团等；R2 代表氢、可能具有取代基的芳基、可能具有取代基的饱和或不饱和 5 至 7 元杂环基团等；R3 代表氢等。Ar 代表衍生自芳香烃的二价基团等；X 代表具有 1 至 3 个碳原子的单键、线性或支链亚烷基（可具有取代基）等；G 代表卤素、饱和或不饱和的 5 或 6 元环状烃基（可具有取代基）、饱和或不饱和的 5 至 7 元杂环基（可具有取代基）等、一种抑制淀粉样蛋白或类淀粉样蛋白聚集和/或沉积的制剂，其中包括该化合物、其盐或其溶液。
• US7855300B2
  申请人：——

  公开号：US7855300B2

  公开（公告）日：2010-12-21