2-氟丙烯酸叔丁酯 | 85345-86-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-氟丙烯酸叔丁酯
• 英文名称: Tert-butyl 2-fluoropropenoate
• 英文别名: tert-butyl 2-fluoroacrylate；t-butyl 2-fluoroacrylate；tert-butyl 2-fluoroprop-2-enoate
• CAS: 85345-86-4
• 化学式: C₇H₁₁FO₂
• mdl: MFCD03094101
• 分子量: 146.162
• InChiKey: PRFZRHRJCVTLFD-UHFFFAOYSA-N

物化性质

• 沸点：
  124 °C
• 密度：
  0.9

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi,T
• 危险类别码：
  R36/37/38
• 海关编码：
  2916190090
• 安全说明：
  S26,S36/37/39

反应信息

• 作为反应物：
  描述：

  N-(甲氧甲基)-N-(三甲基硅甲基)苄胺 、 2-氟丙烯酸叔丁酯 在 palladium 10% on activated carbon 三氟乙酸 、 碳酸氢钠 、 氢气 作用下， 以 二氯甲烷 、 乙醚 、 水 、 甲醇 为溶剂， 生成 tert-butyl 3-fluoropyrrolidine-3-carboxylate
  参考文献：
  名称：

  [EN] AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE
  [FR] COMPOSÉS DE KINASE AURORA ET LEURS MÉTHODES D'UTILISATION

  摘要：

  本文提供了用于治疗由Aurora激酶介导的疾病的吡咯三嗪化合物。还提供了包含这些化合物的药物组合物以及使用这些化合物和组合物的方法。

  公开号：

  WO2011088045A1
• 作为产物：
  描述：

  2-氟-3-(4-甲苯磺酰氧基)丙酸叔丁酯 在 potassium phtalimide 作用下， -78.0~150.0 ℃ 、1.33 Pa 条件下， 以85%的产率得到2-氟丙烯酸叔丁酯
  参考文献：
  名称：

  Tolman, Vladimir; Spronglova, Pavla, Collection of Czechoslovak Chemical Communications, 1983, vol. 48, # 1, p. 319 - 326

  摘要：

  DOI：

文献信息

• Process for the preparation of carboxylic acid esters
  申请人：Souda Hiroshi

  公开号：US20050113581A1

  公开（公告）日：2005-05-26

  There is provided a process for preparing a carboxylic acid ester of formula (3): R 2 COOR 1 (3) wherein R 1 is an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, an aralkyl group which may be substituted, or a heteroarylalkyl group which may be substituted, and R 2 is an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, an aryl group which may be substituted, a heteroaryl which may be substituted, an aralkyl group which may be substituted, or a heteroarylalkyl group which may be substituted, which process is characterized by the steps of reacting a monohydroxy compound of formula (1): R 1 OH   (1) wherein R 1 is as defined above, with a zirconium compound of formula (6): Zr(OR 8 ) 4 (6) wherein R 8 is an alkyl group or an aryl group which may be substituted and is not the same as R 1 , to prepare a zirconium catalyst, and reacting a carboxylic acid of formula (2): R 2 COOH   (2) wherein R 2 is as defined above, with the monohydroxy compound of formula (1) in the presence of the zirconium catalyst.

  提供了一种制备化学式为(3)的羧酸酯的方法：R2COOR1 (3)，其中R1是可以被取代的烷基、可以被取代的烯基、可以被取代的炔基、可以被取代的芳基或可以被取代的杂芳基烷基，R2是可以被取代的烷基、可以被取代的烯基、可以被取代的炔基、可以被取代的芳基、可以被取代的杂芳基、可以被取代的芳基烷基或可以被取代的杂芳基烷基。该方法的特征在于将化学式为(1)的单羟基化合物：R1OH (1)（其中R1如上定义）与化学式为(6)的锆化合物反应：Zr(OR8)4 (6)（其中R8是可以被取代的烷基或芳基，且不同于R1），制备锆催化剂，然后在锆催化剂存在的情况下，将化学式为(2)的羧酸：R2COOH (2)（其中R2如上定义）与化学式为(1)的单羟基化合物反应。
• BICYCLOHEXANE DERIVATIVE AND PRODUCTION METHOD FOR SAME
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP2524907A1

  公开（公告）日：2012-11-21

  A bicyclohexane derivative compound useful in the field of photoresist, the field of intermediate of drugs and pesticides, and the like, and a manufacturing method of the same are provided. A bicyclohexane derivative compound represented by the following general formula (II) is provided. (In formula (II), Y independently represents an alkyl group of 1 to 10 carbons, a halogen atom, an acyloxy group, an alkoxycarbonyl group or a hydroxyl group, X1 represents a halogen atom, m represents an integer of 0 to 11, and m' represents an integer of 0 to 10.)

  提供了一种在光刻胶领域、药物和杀虫剂的中间体领域等领域中有用的一种萜环己烷衍生物化合物，以及其制备方法。提供了由下述通用公式（II）表示的一种萜环己烷衍生物化合物。（在公式（II）中，Y独立表示1至10个碳原子的烷基、卤素原子、酰氧基、烷氧羰基或羟基，X1表示卤素原子，m表示0至11的整数，m'表示0至10的整数。）
• Process for preparing fluorine-containing norbornene derivative
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20040214103A1

  公开（公告）日：2004-10-28

  There are provided a novel norbornene derivative which is a material for a chemically amplifying type photoresist for F 2 laser, possesses excellent transparency and improved dry etching resistivity and has a fluorine-containing ketone unit or fluorine-containing tertiary alcohol unit directly bonded to the norbornene backbone; a fluorine-containing polymer obtained by using the norbornene derivative as a copolymerizable monomer; and a chemically amplifying type photoresist composition comprising the fluorine-containing polymer, a photoacid generator and a solvent.

  提供了一种新型的诺博烯衍生物，可用作F2激光化学扩增型光刻胶的材料，具有优异的透明性和改善的干法蚀刻抗性，并且具有直接连接到诺博烯骨架的含氟酮基或含氟三级醇基；通过使用该诺博烯衍生物作为共聚单体获得的含氟聚合物；以及包括含氟聚合物、光酸发生剂和溶剂的化学扩增型光刻胶组合物。
• Adamantane derivatives and resin compositions using the same as raw material
  申请人：Furukawa Kikuo

  公开号：US20050158662A1

  公开（公告）日：2005-07-21

  The adamantane derivatives of the present invention which are represented by the general formula (1): wherein X is a hydrogen atom, alkyl, halogen-containing alkyl, halogen, or hydroxyl-, halogen-, nitrile- or ether-containing hydrocarbyl, and a plurality of X groups, if any, may be the same or different from each other; n 1 is an integer of 1 to 14; R 1 to R 4 may be the same or different from each other and are independently alkyl or halogen-containing alkyl; and Y 1 and Y 2 may be the same or different from each other and are independently a hydrogen atom or a group represented by the general formula (2): wherein R 5 to R 7 may be the same or different from each other and are independently a hydrogen atom, alkyl, halogen or halogen-containing alkyl, are excellent in optical properties, heat resistance and acid-dissociating property, and useful as crosslinking-type resins, optical materials such as optical fibers, light wave guides, optical disk substrates and photoresists as well as raw materials thereof, intermediate products of medicines or agricultural chemicals, and various other industrial products.

  本发明的金刚烷衍生物由一般式（1）表示：其中X为氢原子，烷基，含卤素的烷基，卤素，或含有羟基，卤素，腈基或醚基的烃基，如果有多个X基团，则它们可以相同或不同；n1为1到14的整数；R1到R4可以相同或不同，且独立地为烷基或含卤素的烷基；Y1和Y2可以相同或不同，且独立地为氢原子或由一般式（2）表示的基团：其中R5到R7可以相同或不同，且独立地为氢原子，烷基，卤素或含卤素的烷基。这些金刚烷衍生物在光学性能，耐热性和酸解离性方面表现优异，并且可用作交联型树脂，光学材料，例如光纤，光波导，光盘基板和光刻胶以及其原材料，药物或农药的中间体和各种其他工业产品。
• Novel oxadiazole compounds
  申请人：Hobson Adrian D.

  公开号：US20080280876A1

  公开（公告）日：2008-11-13

  Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.

  本发明揭示了新型噁二唑化合物、含有该化合物的药物组合物以及将这些化合物或组合物用作S1P家族G蛋白偶联受体的激动剂或拮抗剂，用于治疗与S1P家族受体活性调节相关的疾病，特别是通过提供有益的免疫抑制效应的疾病。