(Z)-1,2-dibromo-1,1,1-trifluoropropene

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: (Z)-1,2-dibromo-1,1,1-trifluoropropene
• 英文别名: 1,2-Dibromo-3,3,3-trifluoropropene；(Z)-1,2-dibromo-3,3,3-trifluoroprop-1-ene
• 化学式: C₃HBr₂F₃
• 分子量: 253.844
• InChiKey: DCJYYAUJHDDEAA-UPHRSURJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2,2-三溴-3,3,3-三氟丙烷 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 (E)-1,2-dibromo-1,1,1-trifluoropropene 、 (Z)-1,2-dibromo-1,1,1-trifluoropropene
  参考文献：
  名称：

  Synthesis of ethyl 3,3,3-trifluoropropionate from 2-bromo-3,3,3-trifluoropropene

  摘要：

  A facile synthesis of ethyl 3,3,3-trifluoropropionate is described. Commercially available 2-bromo-3,3,3-trifluoropropene was used as a starting material, which was allowed to react with bromine to produce 2,2,3-tribromo-1,1,1-trifluoropropane. The resulting tribromide was treated with 3 equiv. of potassium ethoxide, giving rise to ethyl 3,3,3-trifluoropropionate in 60% overall yield in 2 steps. The reaction proceeded via an alkoxide-induced tandem reaction mechanism. (C)2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2014.07.009

文献信息

• Synthesis of ethyl 3,3,3-trifluoropropionate from 2-bromo-3,3,3-trifluoropropene
  作者：Munenori Inoue、Masahiro Shiosaki、Hajime Muramaru

  DOI：10.1016/j.jfluchem.2014.07.009

  日期：2014.11

  A facile synthesis of ethyl 3,3,3-trifluoropropionate is described. Commercially available 2-bromo-3,3,3-trifluoropropene was used as a starting material, which was allowed to react with bromine to produce 2,2,3-tribromo-1,1,1-trifluoropropane. The resulting tribromide was treated with 3 equiv. of potassium ethoxide, giving rise to ethyl 3,3,3-trifluoropropionate in 60% overall yield in 2 steps. The reaction proceeded via an alkoxide-induced tandem reaction mechanism. (C)2014 Elsevier B.V. All rights reserved.