1,1-Dimorpholino-aethan | 2148-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1,1-Dimorpholino-aethan
• 英文别名: 1,1-Dimorpholino-ethan；bismorpholinoethane；dimorpholinoethane；4,4'-ethane-1,1-diyl-bis-morpholine；1,1-bis(N-morpholino)ethylene；1,1-dimorpholino-ethane；4-(1-morpholin-4-ylethyl)morpholine
• CAS: 2148-24-5
• 化学式: C₁₀H₂₀N₂O₂
• 分子量: 200.281
• InChiKey: JDVZLTWRFUQQSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,1-Dimorpholino-aethan 、 二甲基三甲硅基膦酸酯 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 (1-Morpholin-4-yl-ethyl)-phosphonic acid dimethyl ester
  参考文献：
  名称：

  A CONVENIENT DIRECT SYNTHESIS OF α-N,N-DIALKYLAMINOPHOSPHONATES UNDER APROTIC CONDITIONS

  摘要：

  A general one-pot synthesis of N,N-dialkylaminophosphonates under aprotic conditions is proposed using aromatic, heteroaromatic or aliphatic aldehydes and N,N-dialkyl-aminosilanes under trimethylsilyltriflate catalysis.

  DOI：

  10.1080/10426509608046402
• 作为产物：
  描述：

  吗啉 在 potassium carbonate 作用下， 生成 1,1-Dimorpholino-aethan
  参考文献：
  名称：

  Lubricant

  摘要：

  公开号：

  US02388058A1

文献信息

• Quinazolin-4-one derivatives
  申请人：Itai Akiko

  公开号：US20060229324A1

  公开（公告）日：2006-10-12

  A medicament having an inhibitory activity against hematopoietic prostaglandin D2 synthase, which comprises as an active ingredient a compound represented by the following general formula (I) or a salt thereof: wherein X represents a group represented by the formula —N═C(R 5 )— or the formula —NH—CH(R 5 )—, R 1 , R 2 , R 3 , and R 4 represent a hydrogen atom, a halogen atom, a C 1 to C 6 alkyl group, or a hydroxy group, R 5 represents a C 1 to C 6 alkyl group or a C 6 to C 10 aryl group, and R represents an amino group.

  一种具有对造血前列腺素D2合成酶抑制活性的药物，其包括以下一般式（I）所代表的化合物或其盐作为活性成分： 其中X代表由式—N═C(R5)—或式—NH—CH(R5)—所代表的基团，R1、R2、R3和R4代表氢原子、卤原子、C1到C6烷基或羟基，R5代表C1到C6烷基或C6到C10芳基，R代表氨基。
• PROCESS FOR PREPARING TRIMETHYLOL COMPOUNDS AND FORMIC ACID
  申请人：——

  公开号：US20020077502A1

  公开（公告）日：2002-06-20

  The present invention relates to a process for preparing trimethylol compounds and formic acid by reaction of formaldehyde and aldehydes in the presence of a nitrogen base and distillation of the resulting reaction mixture in the presence of an auxiliary.

  本发明涉及一种制备三甲醇化合物和甲酸的方法，其通过在氮碱存在下，将甲醛和醛类化合物反应，并在辅助剂的存在下蒸馏所得反应混合物。
• [EN] ALUMINIUM COMPLEXES AND USE THEREOF AS A CATALYST IN INTRAMOLECULAR RING CLOSURE REACTIONS<br/>[FR] COMPLEXES D'ALUMINIUM ET LEUR UTILISATION EN TANT QUE CATALYSEUR DANS DES RÉACTIONS INTRAMOLÉCULAIRES DE FERMETURE DE CYCLE
  申请人：TAKASAGO PERFUMERY CO LTD

  公开号：WO2010071231A1

  公开（公告）日：2010-06-24

  To provide a process for increasing the proportion of an optical isomer of not only a compound having a closed ring but also a compound not having a closed ring when an optical isomer mixture of a compound having both a formyl group and a double bond capable of causing a carbonyl-ene ring closing reaction in the same molecule is subjected to a ring closing reaction. A process for increasing the proportion of an optical isomer characterized by subjecting an optical isomer mixture of a compound having both a formyl group and a double bond capable of causing a carbonyl-ene ring closing reaction in the same molecule to a ring closing reaction in the presence of a predetermined aluminum complex represented by the general formula: [All(L1)l(L2)m(Lh)n]k.

  提供一种方法，可以在将既有闭环化合物又有非闭环化合物的光学异构体混合物经过环闭合反应时，增加光学异构体的比例。该方法的特征在于，在预定的铝配合物的存在下，将既有醛基又有能够在同一分子中引起羰基-烯反应的双键的化合物的光学异构体混合物进行环闭合反应，从而增加光学异构体的比例。该预定的铝配合物的一般公式为：[All(L1)l(L2)m(Lh)n]k。
• Process for the selective synthesis of tertiary alkanolamines
  申请人：Air Products and Chamicals, Inc.

  公开号：US04680393A1

  公开（公告）日：1987-07-14

  The present invention is a process for the synthesis of tertiary alkanolamines by reacting a secondary amine with an alkanediol. High selectivity for the production of alkanolamines is achieved by carrying out the reaction in the presence of a compound or complex of ruthenium in chemical combination or in admixture with an organic phosphine ligand. The organic phosphine ligand is present in an amount such that the ratio of gram mole ligand/gram atom ruthenium is greater than 5.

  本发明是一种通过将二级胺与烷二醇反应合成三级烷基胺的方法。在存在铑化合物或铑配合物与有机膦配体的化学组合物或混合物的情况下进行反应，可以实现高选择性的烷基胺产物的生产。有机膦配体的含量应使克摩尔配体/克原子铑的比值大于5。
• Process for the selective synthesis of ethylene diamines
  申请人：Air Products and Chemicals, Inc.

  公开号：US04855425A1

  公开（公告）日：1989-08-08

  The present invention is a process for the selective synthesis of alkanediamines by reacting a secondary amine with an alkanediol. High conversions and high selectivity for the production of alkanediamines is achieved by carrying out the reaction in the presence of a compound or complex of ruthenium in the absence of an organic phosphine co-catalyst.

  本发明是一种通过将二级胺与烷二醇反应选择性合成烷基二胺的方法。在无机磷共催化剂的情况下，在钌化合物或络合物的存在下进行反应，可以实现高转化率和高选择性的烷基二胺生产。