3-(5-Hydroxy-1H-indol-3-yl)propanoic acid | 103986-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(5-Hydroxy-1H-indol-3-yl)propanoic acid
• CAS: 103986-23-8
• 化学式: C₁₁H₁₁NO₃
• 分子量: 205.21
• InChiKey: YZIYXJVRBIAHGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  73.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] HIGHLY ACTIVE SELF-SUFFICIENT NITRATION BIOCATALYSTS<br/>[FR] BIOCATALYSEURS DE NITRATION AUTO-SUFFISANTS HAUTEMENT ACTIFS
  申请人：UNIV FLORIDA

  公开号：WO2018081456A1

  公开（公告）日：2018-05-03

  The disclosure relates to the field of fusion proteins. In some aspects, the disclosure relates to artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes and uses thereof. In some aspects, the disclosure relates to compounds produced by artificial cytochrome P450 enzymes.

  该披露涉及融合蛋白的领域。在某些方面，该披露涉及人工融合蛋白，其中包括与还原酶酶相连的细胞色素P450酶，并其用途。在某些方面，该披露涉及由人工细胞色素P450酶产生的化合物。
• Bicyclic heteroaryl derivatives
  申请人：Schmitz Ulrich Franz

  公开号：US20050187390A1

  公开（公告）日：2005-08-25

  Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

  本发明涉及用于治疗黄病毒科病毒感染的化合物、组合物和方法。
• BICYCLIC HETEROARYL DERIVATIVES
  申请人：Schmitz Franz Ulrich

  公开号：US20090081165A1

  公开（公告）日：2009-03-26

  Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.

  本发明揭示了用于治疗黄病毒科病毒感染的化合物、组合物和方法。
• TETRAHYDROISOQUINOLINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP3750886A1

  公开（公告）日：2020-12-16

  Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis. (I)

  本发明公开了一种新型四氢异喹啉化合物、其中间体的制备方法、其药物组合物及其用途。本发明的四氢异喹啉化合物对磷酸二酯酶（PDE4）具有良好的抑制作用，可用于预防、治疗或辅助治疗多种与磷酸二酯酶活性或表达相关的疾病，尤其是与PDE4相关的免疫性和炎症性疾病，如银屑病、关节炎等。(I)
• Scalp care composition with well dispersed particulate scalp benefit agents
  申请人：The Procter & Gamble Company

  公开号：US10463596B1

  公开（公告）日：2019-11-05

  The present invention is directed to a scalp care composition comprising from about 1% to about 99% of a volatile carrier wherein less than about 10% is a volatile solvent; from about 0.05% to about 10% of a polymeric rheology modifier and mixtures thereof; from about 0.03% to about 1% of particulate scalp benefit agent; from about 0.1% to about 5% of a solubilizing agent wherein the composition is shear thinning and has a zero shear viscosity value measured at 0.01 Pa of greater than about 1,500 Pa s.

  本发明涉及一种头皮护理组合物，该组合物包含约 1%至约 99%的挥发性载体，其中挥发性溶剂小于约 10%；约 0.05%至约 10%的聚合流变修饰剂及其混合物；约 0.03%至约 1%的微粒头皮护理剂；约 0.1%至约 5%的增溶剂，其中该组合物为剪切稀释型，在 0.01 Pa 下测得的零剪切粘度值大于约 1,500 Pa s。