potassium 3,4,5-trimethoxyphenylacetate | 1197385-22-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: potassium 3,4,5-trimethoxyphenylacetate
• 英文别名: Potassium;2-(3,4,5-trimethoxyphenyl)acetate；potassium;2-(3,4,5-trimethoxyphenyl)acetate
• CAS: 1197385-22-0
• 化学式: C₁₁H₁₃O₅*K
• 分子量: 264.32
• InChiKey: GWDWCEFMZYVJQE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.99
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  67.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-甲基邻苯二甲酰亚胺 、 potassium 3,4,5-trimethoxyphenylacetate 以 水 、 丙酮 为溶剂， 反应 2.0h， 以50%的产率得到3-hydroxy-2-methyl-3-(3,4,5-trimethoxybenzyl)isoindolin-1-one
  参考文献：
  名称：

  Photodecarboxylative benzylations of phthalimides

  摘要：

  Photoadditions of phenylacetates to phthalimides give the corresponding benzylated hydroxyphthalimidines in moderate to high yields of 29-90%. With 2-phenylpropanoate, photoaddition affords a diastereoisomeric mixture in a de of 24% in favour of the like-diastereoisomer. L-3-Phenyl lactate and 2-oxo-3-phenylpropanoate both furnish the benzylated product through subsequent loss of formaldehyde and decarbonylation, respectively. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.115

文献信息

• Photodecarboxylative benzylations of phthalimide in pH 7 buffer: a simple access to 3-arylmethyleneisoindolin-1-ones
  作者：Vincent Belluau、Pierre Noeureuil、Elfrun Ratzke、Aleksei Skvortsov、Sonia Gallagher、Cherri Ann Motti、Michael Oelgemöller

  DOI：10.1016/j.tetlet.2010.07.017

  日期：2010.9

  Photoadditions of phenylacetates to phthalimide in pH 7 buffer solution give the corresponding benzylated-hydroxyphthalimidines in moderate to high yields of up to 94%. In a micro-structured reactor, higher conversions and purities are achieved. With branched phenylacetates, photoaddition affords diastereoisomeric mixtures with low to moderate de values. Subsequent acid-catalyzed dehydration furnishes the corresponding 3-arylmethyleneisoindolin-1-ones in good to excellent yields and with high E-selectivities. Irradiation of the parent 3-phenylmethyleneisoindolin-1-one under oxidative conditions only leads to cis/trans-isomerization. (C) 2010 Elsevier Ltd. All rights reserved.
• Photodecarboxylative benzylations of phthalimides
  作者：Fadi Hatoum、Sonia Gallagher、Louise Baragwanath、Johann Lex、Michael Oelgemöller

  DOI：10.1016/j.tetlet.2009.08.115

  日期：2009.11

  Photoadditions of phenylacetates to phthalimides give the corresponding benzylated hydroxyphthalimidines in moderate to high yields of 29-90%. With 2-phenylpropanoate, photoaddition affords a diastereoisomeric mixture in a de of 24% in favour of the like-diastereoisomer. L-3-Phenyl lactate and 2-oxo-3-phenylpropanoate both furnish the benzylated product through subsequent loss of formaldehyde and decarbonylation, respectively. (C) 2009 Elsevier Ltd. All rights reserved.