1,12-dodecanediylbis(methanesulfonate) | 106731-55-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1,12-dodecanediylbis(methanesulfonate)
• 英文别名: 12-Methylsulfonyloxydodecyl methanesulfonate
• CAS: 106731-55-9
• 化学式: C₁₄H₃₀O₆S₂
• 分子量: 358.521
• InChiKey: MZUWYNWIVQCHAE-UHFFFAOYSA-N

物化性质

• 沸点：
  515.6±23.0 °C(Predicted)
• 密度：
  1.140±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,12-dodecanediylbis(methanesulfonate) 在 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 16.0h， 以1.85 g的产率得到1,12-二碘十二烷
  参考文献：
  名称：

  Synthesis of both enantiomers of akolactone B and (+)-ancepsenolide

  摘要：

  The syntheses of (+)- and (-)-akolactone B and (+)-ancepsenolide were accomplished using a Pd-catalyzed carbonylation. As to the absolute configuration of akolactone B, making a comparison of the specific rotation of both enantiomers of synthetic akolactone B and the natural compound suggests that the absolute configuration at the 4-position of akolactone B is (R). (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2014.08.008
• 作为产物：
  描述：

  1,12-十二烷二醇 、 甲基磺酰氯 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 1.0h， 生成 1,12-dodecanediylbis(methanesulfonate)
  参考文献：
  名称：

  Organocatalytic synthesis of new telechelic polycarbonates and study of their chemical reactivity

  摘要：

  A two-step versatile process for telechelic polycarbonates synthesis is described. 1-n-butyl-3-methylimidazolium-2-carboxylate (BMIM-2-CO2) was used as thermolabile precursor of N-heterocyclic carbene (NHC) organocatalyst. In a first step, synthesized branched fatty diols or commercially available linear diols were reacted with an excess of dimethylcarbonate (DMC) to afford oligocarbonates with methylcarbonate end-groups. Then, the methylcarbonate groups were reacted with hydroxyl groups of 9-decen-1-ol, 4-hexyn-1-ol and 4-hydroxybenzene ethanol leading to telechelic oligomers with alkene, alkyne and phenol functionalities. Reactivity of these end-groups towards polymerization was successfully evidenced. This procedure could be used for preparing a range of new telechelic oligocarbonates. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2015.04.046

文献信息

• [EN] BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME<br/>[FR] LIGANDS BROMODOMAINES BIVALENTS ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：COFERON INC

  公开号：WO2015081284A1

  公开（公告）日：2015-06-04

  Described herein are compounds capable of modulating one or more biomolecules substantially simultaneously, e.g., modulating two or more binding domains (e.g., bromodomains) on a protein or on different proteins. For example, in one aspect, a bivalent compound or a pharmaceutically acceptable salt, stereoisomer, metabolite, or hydrate thereof is provided. In another aspect, a method of treating a disease associated with a protein having tandem bromodomains in a patient in need thereof is provided. The method comprises administering to the patient the bivalent compound as described.

  本文描述了一种能够同时调节一个或多个生物分子的化合物，例如，在蛋白质上或在不同蛋白质上调节两个或更多结合结构域（例如溴结构域）。例如，在一个方面，提供了一种二价化合物或药用盐、立体异构体、代谢物或其水合物。在另一个方面，提供了一种治疗与患有串联溴结构域蛋白相关的疾病的方法，该方法包括向患者注射所述的二价化合物。
• Two-directional cascade molecules: synthesis and characterization of [9]-n-[9] arborols
  作者：George R. Newkome、Gregory R. Baker、Mary Jane Saunders、Paul S. Russo、Vinod K. Gupta、Zhong-qi Yao、Joseph E. Miller、Kelly Bouillion

  DOI：10.1039/c39860000752

  日期：——

  A series of two-directional cascade molecules (arborols) has been synthesized by a two-step nucleophilic substitution–amidation procedure; the [9]-10-[9] arborol forms a thermally reversible aqueous gel, which has been investigated via microscopy and light scattering techniques.

  通过两步亲核取代-酰胺化过程已经合成了一系列双向级联分子（硼烷）。[9] -10- [9]植烷醇形成热可逆的水凝胶，已通过显微镜和光散射技术对其进行了研究。
• Processes using alpha, omega-difunctional aldaramides as monomers and crosslinkers
  申请人：Andrews Allen Mark

  公开号：US20060264672A1

  公开（公告）日：2006-11-23

  Processes using alpha, omega-difunctional aldaramides as monomers and crosslinkers are disclosed. The processes can be used to form polymers, particularly crosslinked polymers.

  本发明公开了使用α，ω-双官能团醛胺作为单体和交联剂的过程。该过程可用于形成聚合物，特别是交联聚合物。
• PROCESSES FOR PREPARING POLYMERS USING ALPHA,OMEGA-DIFUNCTIONAL ALDARAMIDES
  申请人：Andrews Mark Allen

  公开号：US20080146768A1

  公开（公告）日：2008-06-19

  Processes using alpha, omega-difunctional aldaramides as monomers and crosslinkers are disclosed. The processes can be used to form polymers, particularly crosslinked polymers.

  本发明揭示了使用α，ω-二官能团醛胺作为单体和交联剂的过程。该过程可用于形成聚合物，特别是交联聚合物。
• Cheng, P.; Blumstein, A.; Subramanyam, S., Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1995, vol. 269, p. 1 - 38
  作者：Cheng, P.、Blumstein, A.、Subramanyam, S.

  DOI：——

  日期：——