2-methyl-7-phenyl-3-(prop-2-ynyl)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-4(3H)-one | 1314534-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-methyl-7-phenyl-3-(prop-2-ynyl)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-4(3H)-one
• 英文别名: 2-Methyl-7-phenyl-3-prop-2-ynyl-5-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-one
• CAS: 1314534-95-6
• 化学式: C₁₈H₁₂F₃N₃O
• 分子量: 343.308
• InChiKey: WHNLXNLGNIARMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-methyl-7-phenyl-3-(prop-2-ynyl)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-4(3H)-one 、 叠氮苯 在 copper(l) iodide 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以96%的产率得到2-methyl-7-phenyl-3-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-5-(trifluoromethyl) pyrido[2,3-d]pyrimidin-4(3H)-one
  参考文献：
  名称：

  Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

  摘要：

  A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting from 2,3-active functional pyridine 1 via cyclization, propargylation followed by reaction with alkyl or perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for anticancer activity against three cancer cell lines such as U-937, THP-1 and Colo205. The promising compounds 5b and Se have been identified. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.05.011
• 作为产物：
  描述：

  2-氨基-6-苯基-4-(三氟甲基)吡啶-3-甲腈 在 硫酸 、 potassium carbonate 、 potassium iodide 作用下， 以 丙酮 为溶剂， 生成 2-methyl-7-phenyl-3-(prop-2-ynyl)-5-(trifluoromethyl)pyrido[2,3-d]pyrimidine-4(3H)-one
  参考文献：
  名称：

  Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

  摘要：

  A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting from 2,3-active functional pyridine 1 via cyclization, propargylation followed by reaction with alkyl or perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for anticancer activity against three cancer cell lines such as U-937, THP-1 and Colo205. The promising compounds 5b and Se have been identified. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.05.011

文献信息

• Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity
  作者：C. Kurumurthy、P. Sambasiva Rao、B. Veera swamy、G. Santhosh kumar、P. Shanthan Rao、B. Narsaiah、L.R. Velatooru、R. Pamanji、J. Venkateswara Rao

  DOI：10.1016/j.ejmech.2011.05.011

  日期：2011.8

  A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting from 2,3-active functional pyridine 1 via cyclization, propargylation followed by reaction with alkyl or perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for anticancer activity against three cancer cell lines such as U-937, THP-1 and Colo205. The promising compounds 5b and Se have been identified. (C) 2011 Elsevier Masson SAS. All rights reserved.