1-(4-(3-hydroxyphenyl)-2-methyl-1-(prop-2-ynyl)-1H-pyrrol-3-yl)ethanone | 1429632-72-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(4-(3-hydroxyphenyl)-2-methyl-1-(prop-2-ynyl)-1H-pyrrol-3-yl)ethanone
• 英文别名: 1-[4-(3-Hydroxyphenyl)-2-methyl-1-prop-2-ynylpyrrol-3-yl]ethanone；1-[4-(3-hydroxyphenyl)-2-methyl-1-prop-2-ynylpyrrol-3-yl]ethanone
• CAS: 1429632-72-3
• 化学式: C₁₆H₁₅NO₂
• 分子量: 253.301
• InChiKey: ZLBBXIQVXKKHLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  硝基甲烷 、 间羟基苯甲醛 、 乙酰丙酮 、 炔丙胺 在 1-n-butylimidazolium tetrafluoroborate 作用下， 反应 0.97h， 以94%的产率得到1-(4-(3-hydroxyphenyl)-2-methyl-1-(prop-2-ynyl)-1H-pyrrol-3-yl)ethanone
  参考文献：
  名称：

  Catalyst-free four-component protocol for the synthesis of substituted pyrroles under reusable reaction media

  摘要：

  An efficient four-component protocol is described for the synthesis of diversely functionalized pyrroles under catalyst-free condition by using ionic liquid as a reaction media. The developed method is mild, high yielding, and amenable for a variety of amines as well as aldehydes. Moreover the procedure is of environmentally benign nature in which ionic liquid 1-n-butylimidazolium tetrafluoroborate [Hbim]BF4 is used as a reusable and efficient reaction medium without using any additional catalyst or promoter. (C) 2013 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2013.01.098

文献信息

• Catalyst-free four-component protocol for the synthesis of substituted pyrroles under reusable reaction media
  作者：H.M. Meshram、B. Madhu Babu、G. Santosh Kumar、Pramod B. Thakur、Vikas M. Bangade

  DOI：10.1016/j.tetlet.2013.01.098

  日期：2013.5

  An efficient four-component protocol is described for the synthesis of diversely functionalized pyrroles under catalyst-free condition by using ionic liquid as a reaction media. The developed method is mild, high yielding, and amenable for a variety of amines as well as aldehydes. Moreover the procedure is of environmentally benign nature in which ionic liquid 1-n-butylimidazolium tetrafluoroborate [Hbim]BF4 is used as a reusable and efficient reaction medium without using any additional catalyst or promoter. (C) 2013 Published by Elsevier Ltd.