N,N-bis(succinimidomethyl)methylamine | 92486-60-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-bis(succinimidomethyl)methylamine
• 英文别名: 1,1'-[(Methylazanediyl)bis(methylene)]di(pyrrolidine-2,5-dione)；1-[[(2,5-dioxopyrrolidin-1-yl)methyl-methylamino]methyl]pyrrolidine-2,5-dione
• CAS: 92486-60-7
• 化学式: C₁₁H₁₅N₃O₄
• 分子量: 253.258
• InChiKey: ZLFOXAPARJYXQI-UHFFFAOYSA-N

物化性质

• 沸点：
  508.1±35.0 °C(Predicted)
• 密度：
  1.384±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  78
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N-bis(succinimidomethyl)methylamine 在 溶剂黄146 、 sodium nitrite 作用下， 反应 6.0h， 以89.7%的产率得到N-nitroso-N-(succinimidomethyl)methylamine
  参考文献：
  名称：

  摘要：

  The reactions of isatin. benzotriazole. and succinimide with formaldehyde and methylamine yield monoamines RCH2N(Me)CH2R and methylenediamines RCH2N(Me)CH2N(Me)CH2R. The use of ethylenediamine as the amino component affords N,N'-disubstituted imidazolidines, while the reactions with 3-aminopropan-1-ol give N-substituted tetrahydro-1,3-oxazines. RCH2NBu21 was obtained from succinimide. formaldehyde, and diisobutylamine. Nitrosative cleavage of the amines obtained was studied: it was shown that monoamines and methylenediamines give N-nitrosoamines RCH2N(NO)Me, which were structurally characterized by X-ray diffraction analysis, RCH2NBu21 affords diisobutylnitrosamine. while imidazolidines transform into dinitroso compounds RCH2N(NO)CH2CH2N(NO)CH2R.

  DOI：

  10.1023/a:1013094720611
• 作为产物：
  描述：

  丁二酰亚胺 、 聚合甲醛 、 甲胺 以 水 、 异丙醇 为溶剂， 反应 4.0h， 以81%的产率得到N,N-bis(succinimidomethyl)methylamine
  参考文献：
  名称：

  摘要：

  The reactions of isatin. benzotriazole. and succinimide with formaldehyde and methylamine yield monoamines RCH2N(Me)CH2R and methylenediamines RCH2N(Me)CH2N(Me)CH2R. The use of ethylenediamine as the amino component affords N,N'-disubstituted imidazolidines, while the reactions with 3-aminopropan-1-ol give N-substituted tetrahydro-1,3-oxazines. RCH2NBu21 was obtained from succinimide. formaldehyde, and diisobutylamine. Nitrosative cleavage of the amines obtained was studied: it was shown that monoamines and methylenediamines give N-nitrosoamines RCH2N(NO)Me, which were structurally characterized by X-ray diffraction analysis, RCH2NBu21 affords diisobutylnitrosamine. while imidazolidines transform into dinitroso compounds RCH2N(NO)CH2CH2N(NO)CH2R.

  DOI：

  10.1023/a:1013094720611

文献信息

• TRIMETHYLSILYL TRIFLATE-CATALYZED REACTION OF BIS(METHYLTHIOMETHYL)AMINES WITH DIKETENE SILYL ACETALS. NOVEL CYCLIZATION LEADING TO FIVE- TO SEVEN-MEMBERED ALICYCLIC AMINES
  作者：Shuhei Miyazawa、Kiyoshi Ikeda、Kazuo Achiwa、Minoru Sekiya

  DOI：10.1246/cl.1984.785

  日期：1984.5.5

  Bis(methylthiomethyl)amines have been shown to react with diketene silyl acetals in the presence of trimethylsilyl triflate catalyst to give five- to seven-membered alicyclic amines.

  双(美基硫甲基)胺已被证明可以在三甲基硅基三氟甲磺酸酯催化剂存在下，与二酮硅乙醇反应，生成五至七员环状脂肪胺。
• MIYAZAWA, HUHEI;IKEDA, KIYOSHI;ACHIWA, KAZUO;SEKIYA, MINORU, CHEM. LETT., 1984, N 5, 785-788
  作者：MIYAZAWA, HUHEI、IKEDA, KIYOSHI、ACHIWA, KAZUO、SEKIYA, MINORU

  DOI：——

  日期：——
• ——
  作者：A. G. Korepin、P. V. Galkin、N. M. Glushakova、V. P. Lodygina、I. L. Eremenko、S. E. Nefedov、L. T. Eremenko

  DOI：10.1023/a:1013094720611

  日期：——

  The reactions of isatin. benzotriazole. and succinimide with formaldehyde and methylamine yield monoamines RCH2N(Me)CH2R and methylenediamines RCH2N(Me)CH2N(Me)CH2R. The use of ethylenediamine as the amino component affords N,N'-disubstituted imidazolidines, while the reactions with 3-aminopropan-1-ol give N-substituted tetrahydro-1,3-oxazines. RCH2NBu21 was obtained from succinimide. formaldehyde, and diisobutylamine. Nitrosative cleavage of the amines obtained was studied: it was shown that monoamines and methylenediamines give N-nitrosoamines RCH2N(NO)Me, which were structurally characterized by X-ray diffraction analysis, RCH2NBu21 affords diisobutylnitrosamine. while imidazolidines transform into dinitroso compounds RCH2N(NO)CH2CH2N(NO)CH2R.