N-(cyclohexylmethyl)pivalamide | 1197966-23-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(cyclohexylmethyl)pivalamide
• 英文别名: N-(cyclohexylmethyl)-2,2-dimethylpropanamide
• CAS: 1197966-23-6
• 化学式: C₁₂H₂₃NO
• mdl: MFCD13521960
• 分子量: 197.321
• InChiKey: BPUXMRCTHGHLRL-UHFFFAOYSA-N

物化性质

• 沸点：
  333.6±11.0 °C(Predicted)
• 密度：
  0.913±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.916
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(cyclohexylmethyl)pivalamide 在 甲醇 、 dipotassium peroxodisulfate 、 palladium diacetate 、 potassium carbonate 作用下， 反应 20.0h， 生成 N-(cyclohexylmethyl)-3-hydroxy-2,2-dimethylpropanamide
  参考文献：
  名称：

  Palladium-Catalyzed β-Acyloxylation of Simple Amide via sp³ C–H Activation

  摘要：

  beta-Acylcoxy amides are prepared in moderate to high yields by palladium-catalyzed acyloxylation of primary sp(3) C-H bonds from simple amides without any special directing group. A catalytic system of Pd(OAc)(2)/CF3CO2H/K2S2O8 is available to various amides with N-substituted by linear alkanes, cyclic alkanes, and electron-deficient benzyl compounds in this reaction. Acyloxylated products could be transformed easily to the corresponding beta-hydroxy amides.

  DOI：

  10.1021/ol403393w
• 作为产物：
  描述：

  三甲基乙酰氯 、 环己甲胺 在 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 生成 N-(cyclohexylmethyl)pivalamide
  参考文献：
  名称：

  Palladium-Catalyzed β-Acyloxylation of Simple Amide via sp³ C–H Activation

  摘要：

  beta-Acylcoxy amides are prepared in moderate to high yields by palladium-catalyzed acyloxylation of primary sp(3) C-H bonds from simple amides without any special directing group. A catalytic system of Pd(OAc)(2)/CF3CO2H/K2S2O8 is available to various amides with N-substituted by linear alkanes, cyclic alkanes, and electron-deficient benzyl compounds in this reaction. Acyloxylated products could be transformed easily to the corresponding beta-hydroxy amides.

  DOI：

  10.1021/ol403393w

文献信息

• OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY
  申请人：Sudo Masaki

  公开号：US20110312933A1

  公开（公告）日：2011-12-22

  The present invention relates to novel oxyindole derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the motilin receptor (GPR38).

  本发明涉及公式（I）的新型氧化吲哚衍生物或其药学上可接受的盐，其制备方法，含有它们的制药组合物以及它们在治疗通过胃动素受体（GPR38）介导的各种疾病中的使用。
• Heterocyclic Compounds Which Modulate The CB2 Receptor
  申请人：Bartolozzi Alessandra

  公开号：US20110312944A1

  公开（公告）日：2011-12-22

  Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  本发明揭示了调节CB2受体的化合物。根据本发明，这些化合物与CB2受体结合并作为激动剂，用于治疗炎症。那些作为激动剂的化合物还可用于治疗疼痛。
• ALPHA HELIX MIMETICS AND METHODS RELATING THERETO
  申请人：Odagami Takenao

  公开号：US20120088770A1

  公开（公告）日：2012-04-12

  Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a chemical library relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

  本文披露了代表公式(I)的α-螺旋类似物结构和化合物，其中一般公式和每个符号的定义如规范所定义，以及与之相关的化学库和方法。此外，还披露了这些化合物在治疗医疗状况（例如癌症疾病、纤维化疾病）方面的应用，以及包括类似物的制药组合物。
• Pyrrolidine Compounds Which Modulate The CB2 Receptor
  申请人：Berry Angela

  公开号：US20120142677A1

  公开（公告）日：2012-06-07

  Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. (I)

  本发明揭示了调节CB2受体的化合物。本发明的化合物结合并激动CB2受体，并且可用于治疗炎症。那些是激动剂的化合物还可用于治疗疼痛。 (I)
• C-4" POSITION SUBSTITUTED MACROLIDE DERIVATIVE
  申请人：Sugimoto Tomohiro

  公开号：US20140046043A1

  公开（公告）日：2014-02-13

  A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas).

  一种大环内酯化合物，化学式为（I），对红霉素耐药的细菌有效（例如，耐药的肺炎球菌，链球菌和支原体）。