dibenzyl itaconate | 58991-67-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dibenzyl itaconate
• 英文别名: dibenzyl 2-methylidenebutanedioate
• CAS: 58991-67-6
• 化学式: C₁₉H₁₈O₄
• 分子量: 310.35
• InChiKey: WZAPMKYCDNQBOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dibenzyl itaconate 在 palladium on activated charcoal 正丁基锂 、 氢气 、 三甲基铝 作用下， 以 甲醇 为溶剂， 25.0 ℃ 、275.79 kPa 条件下， 反应 40.33h， 生成 1-Phosphonopropane-2,3-dicarboxylic acid
  参考文献：
  名称：

  Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated α-Linked Acidic Dipeptidase

  摘要：

  A series of substituted phosphonate derivatives were designed and synthesized in order to study the ability of these compounds to inhibit the neuropeptidase N-acetylated alpha-linked acidic dipeptidase (NAALADase). The molecules were shown to act as inhibitors of the enzyme, with the most potent (compound 3) having a K-i of 0.275 nM. The potency of this compound is more than 1000 times greater than that of previously reported inhibitors of the enzyme. NAALADase is responsible for the catabolism of the abundant neuropeptide N-acetyl-L-aspartylglutamate (NAAG) into N-acetylaspartate and glutamate. NAAG has been proposed to be a neurotransmitter at a subpopulation of glutamate receptors; alternatively, NAAG has been suggested to act as a storage form of synaptic glutamate. As a result, inhibition of NAALADase may show utility as a therapeutic intervention in diseases in which altered levels of glutamate are thought to be involved.

  DOI：

  10.1021/jm950801q
• 作为产物：
  描述：

  衣康酸 、 溴甲苯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 dibenzyl itaconate
  参考文献：
  名称：

  Design and Pharmacological Activity of Phosphinic Acid Based NAALADase Inhibitors

  摘要：

  A novel series of phosphinic acid based inhibitors of the neuropeptidase NAALADase are described in this work. This series of compounds is the most potent series of inhibitors of the enzyme described to date. In addition, we have shown that these compounds are protective in animal models of neurodegeneration. Compound 34 significantly prevented neurodegeneration in a middle cerebral artery occlusion model of cerebral ischemia. In addition, in the chronic constrictive mc del of neuropathic pain, compound 34 significantly attenuated the hypersensitivity observed with saline-treated animals. These data suggest that NAALADase inhibition may provide a new approach for the treatment of both neurodegenerative disorders and peripheral neuropathies.

  DOI：

  10.1021/jm0001774

文献信息

• The tandem reaction combining radical and ionic processes: an efficient approach to substituted 3,4-dihydroquinolin-2-ones
  作者：Wang Zhou、Liangren Zhang、Ning Jiao

  DOI：10.1016/j.tet.2009.01.027

  日期：2009.3

  pharmaceuticals. However, the direct intramolecular radical cyclizations of the corresponding amide compounds favor 5-exo products 2. Reports on the radical cyclization reactions producing 3,4-dihydroquinolin-2-one derivatives are limited. Herein, an efficient tandem reaction combining radical and ionic processes was developed, which provides a practical synthetic strategy for the synthesis of substituted

  3，4-二氢喹啉-2-酮在药物领域中非常重要。然而，相应酰​​胺化合物的直接分子内自由基环化有利于5- exo产物2。关于产生3，4-二氢喹啉-2-酮衍生物的自由基环化反应的报道是有限的。本文中，开发了一种结合自由基和离子过程的有效串联反应，其为在中性反应条件下由简单易得的前体合成取代的3,4-二氢喹啉-2-酮提供了实用的合成策略。
• Acid-degradable resin compositions containing ketene-aldehyde copolymer
  申请人：Sudo Atsushi

  公开号：US20050130057A1

  公开（公告）日：2005-06-16

  It is intended to provide compositions to be used in resists and the like for forming fine patterns with a high sensitivity and a high resolution by increasing the difference in the solubilities between exposed parts and unexposed parts. Acid-degradable compositions contain a polymer having a repeating unit represented by the following general formula (I): wherein R 1 and R 2 independently represent hydrogen atom, halogen atom, C 1-20 hydrocarbon group, a heterocyclic group, a cyano group, a nitro group, C(═O)R 4 group, S(O) n R 4 group, P(═O)(R 4 ) 2 group or M(R 4 ) 3 group; R 3 represents C 1-20 hydrocarbon group or a heterocyclic group: R 4 represents C 1-20 hydrocarbonoxy group, C 1-20 hydrocarbon group, C 1-20 hydrocarbonthio group or mono- or di-C 1-20 hydrocarbonamino group; M represents a silicon, germanium, tin or lead atom; and n is 0, 1 or 2 , and an acid or a compound capable of generating an acid in response to an external stimulus.

  本发明旨在提供用于制备高灵敏度和高分辨率细微图案的抗蚀剂等组合物，通过增加曝光部分和未曝光部分之间的溶解度差异。可降解酸性组合物包含具有以下通式（I）所表示的重复单元的聚合物：其中，R1和R2独立地表示氢原子、卤素原子、C1-20碳氢基团、杂环基团、氰基团、硝基团、C（═O）R4基团、S（O）nR4基团、P（═O）（R4）2基团或M（R4）3基团；R3表示C1-20碳氢基团或杂环基团；R4表示C1-20碳氢氧基团、C1-20碳氢基团、C1-20碳氢硫基团或单烷基或二烷基氨基基团；M表示硅、锗、锡或铅原子；n为0、1或2，以及一种酸或能够响应外部刺激产生酸的化合物。
• Ink-jet recording ink, ink-jet recording ink set, recording method, print, and ink-jet recording apparatus
  申请人：——

  公开号：US20030106462A1

  公开（公告）日：2003-06-12

  Provided are an ink jet recording ink (IJ ink), an ink jet recording ink set (IJ ink set) and a recording method, having excellent dispersion stability and ejection stability and being capable of providing images which is free from bleeding and which is excellent in color development property and rubbing resistance. An IJ ink and an IJ ink set having long-term storage stability are provided. Also provided are recorded matter having excellent color development property and rubbing resistance, and an ink jet recording apparatus capable of providing the same. The invention includes: an IJ ink containing a colorant of a pigment and/or dye enveloped in a polymer, and water, and containing at least one compound selected from the group consisting of acetylene glycol surfactants, acetylene alcohol surfactants, glycol ethers and 1,2-alkylene glycols; an IJ ink set comprising a plurality of the inks; a recording method of using the ink and/or the ink set; recorded matter printed according to the recording method; and an ink jet recording apparatus having an electrostrictive unit mounted thereon and is designed so as to be capable of ejecting the ink.

  提供了一种喷墨记录墨水（IJ墨水），一种喷墨记录墨水组合（IJ墨水组），以及一种记录方法，具有优异的分散稳定性和喷射稳定性，并能够提供无渗透和色彩发展性和耐磨性优异的图像。提供了具有长期储存稳定性的IJ墨水和IJ墨水组。还提供了具有优异的色彩发展性和耐磨性的记录物，以及能够提供相同效果的喷墨记录设备。该发明包括：一种含有被聚合物包覆的颜料和/或染料的色素的IJ墨水，以及水，且至少含有从乙炔二醇表面活性剂，乙炔醇表面活性剂，乙二醇醚和1,2-烷基二醇组成的群体中选择的一种化合物; 一种包括多种墨水的IJ墨水组；使用墨水和/或墨水组的记录方法；根据记录方法打印的记录物；以及具有电致伸缩单元的喷墨记录设备，其设计为能够喷射墨水。
• Aqueous ink composition, and ink jet recording method and recorded matter using the same
  申请人：Ota Hitoshi

  公开号：US20060173096A1

  公开（公告）日：2006-08-03

  The present invention provides n aqueous ink composition comprising a coloring component, an acetylene glycol-based surfactant, water, and a urea derivative, wherein the coloring component is a dispersion substance in which a colorant is enclosed with a dispersing polymer thereby being rendered dispersible in water, wherein the dispersing polymer comprises a hydrophobic part and a hydrophilic part, wherein at least a part of the hydrophilic part is a neutralized group obtained by neutralizing an unneutralized group constituting a part of the hydrophilic part, and wherein the neutralized groups are present within an amount range of from 20% to less than 60% in terms of molar ratio based on the sum of the neutralized groups and the unneutralized groups.

  本发明提供了一种包括着色组分、基于乙炔二醇的表面活性剂、水和脲衍生物的水性油墨组合物，其中着色组分是一种分散物质，其中颜料与分散聚合物一起封闭，从而使其能够在水中分散，其中分散聚合物包括疏水部分和亲水部分，其中至少部分亲水部分是通过中和构成亲水部分的未中和基团而获得的中和基团，其中中和基团在摩尔比例上基于中和基团和未中和基团的总和而在20%到小于60%的范围内存在。
• Acrylic Acid-Based Polymer and Method of Producing the Same
  申请人：Kubo Hideo

  公开号：US20090111961A1

  公开（公告）日：2009-04-30

  Disclosed are an acrylic acid-based polymer which is a star polymer containing a repeating unit derived from an (α-lower alkyl)acrylic ester represented by formula (I): (wherein R 1 represents a hydrogen atom or a lower alkyl group, and R 2 represents an organic group having a polar group) in an arm portion; an acrylic acid-based polymer containing a repeating unit derived from an poly(α-lower alkyl)acrylic ester and a repeating unit derived from an (α-lower alkyl)acrylic ester represented by formula (I), and a method for producing a polymer through living polymerization, comprising forming an oligomer having a polymerization active end, which is an oligomer higher than an average 1.0-mer and lower than an average 4.0-mer or an average 4.0-mer, and polymerizing using the oligomer having a polymerization active end as an initiating species.

  本发明涉及一种基于丙烯酸的星型聚合物，其包含来自式（I）所表示的（α-较低烷基）丙烯酸酯的重复单元的臂部分；以及一种基于丙烯酸的聚合物，其包含来自聚（α-较低烷基）丙烯酸酯和式（I）所表示的（α-较低烷基）丙烯酸酯的重复单元，并且本发明还提供了通过活性聚合制备聚合物的方法，包括形成具有聚合活性端的寡聚体，该寡聚体高于平均1.0-聚体但低于平均4.0-聚体或平均4.0-聚体，并以具有聚合活性端的寡聚体作为引发物种进行聚合。