(R)-2-Isobutylmorpholine | 746585-30-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (R)-2-Isobutylmorpholine
• 英文别名: (2R)-2-(2-methylpropyl)morpholine
• CAS: 746585-30-8
• 化学式: C₈H₁₇NO
• 分子量: 143.23
• InChiKey: HNDXEVBVCNVVOW-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PYRAZOLYL DERIVATIVES AS SYK INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150191461A1

  公开（公告）日：2015-07-09

  The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

  本发明提供了公式I的新型吡唑衍生物，它们是脾酪氨酸激酶的有效抑制剂，并可用于治疗和预防由该酶介导的疾病，如哮喘、慢性阻塞性肺疾病、类风湿性关节炎和癌症。
• Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof
  申请人：Crinetics Pharmaceuticals, Inc.

  公开号：US10604507B2

  公开（公告）日：2020-03-31

  Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.

  本文描述了黑色素皮质素亚型-2 受体（MC2R）调节剂化合物、制造此类化合物的方法、包含此类化合物的药物组合物和药物，以及使用此类化合物治疗可从调节 MC2R 活性中获益的病症、疾病或紊乱的方法。
• MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF
  申请人：Crinetics Pharmaceuticals, Inc.

  公开号：US20210002254A1

  公开（公告）日：2021-01-07

  Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.
• US9242984B2
  申请人：——

  公开号：US9242984B2

  公开（公告）日：2016-01-26
• [EN] ALKYL 2 beta -MORPHOLINO-ANDROSTANE DERIVATIVES<br/>[FR] DERIVES ALKYLE-2 beta -MORPHOLINO-ANDROSTANE
  申请人：AKZO NOBEL N.V.

  公开号：WO1996038465A1

  公开（公告）日：1996-12-05

  (EN) This invention is related to alkyl substituted 2$g(b)-morpholino-androstane derivatives, bonded at their 2$g(b)-position to the nitrogen of a group of formula (I), wherein Ra represents (3-6C) alkyl; Rb represents H or (3-6C) alkyl; and Y is O or S; or a pharmaceutically acceptable salt thereof. These steroids are very potent intravenous anaesthetics. The compounds have fast onset times and ideal 'sleep duration' vs. 'recovery to full coordination' profiles.(FR) L'invention concerne des dérivés 2$g(b)-morpholino-androstane substitués par alkyle, liés en position 2$g(b) à l'azote d'un groupe de la formule (I) dans laquelle Ra désigne alkyle (3-6C); Rb désigne H ou alkyle (3-6C), et Y désigne O ou S; ou un de leurs sels pharmaceutiquement acceptables. Ces stéroïdes constituent des anesthésiques intraveineux extrêmement puissants. Ces composés présentent des délais d'action rapides et des courbes idéales de 'durée de sommeil' / 'récupération jusqu'à parfaite coordination'.