(4S,5R)-5-hydroxy-4-methylhept-2-enoic acid | 138223-69-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (4S,5R)-5-hydroxy-4-methylhept-2-enoic acid
• 英文别名: Mycinonic acid I；(E,4S,5R)-5-hydroxy-4-methylhept-2-enoic acid
• CAS: 138223-69-5
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: SUTQROWYWGRRPW-LYNIJRAASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Novel polyketides and antibiotics
  申请人：——

  公开号：US20030092140A1

  公开（公告）日：2003-05-15

  Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.

  本发明公开了制备二酮和三酮硫酯的简便方法。所得的硫酯可用作所需聚酮合成中间体，且可能含有功能基团，最终存在于所得聚酮的侧链中，因此可进一步用于操纵聚酮形成衍生物。所生产的聚酮也可通过糖基化、羟基化等方式进行定制。因此，本发明生产了新的聚酮及其衍生物和定制形式。
• Synthesis of oligoketides
  申请人：Kosan Biosciences, Inc.

  公开号：EP1754700A2

  公开（公告）日：2007-02-21

  Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as to form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.

  本发明公开了制备二酮和三酮硫酯的简便方法。所得硫酯可用作合成所需聚酮类化合物的中间体，并可含有最终位于所得聚酮类化合物侧链中的官能团，因此可进一步用于操纵聚酮类化合物以形成衍生物。还可以通过糖基化、羟基化等方法对制备的多酮苷进行定制。从而生产出新的多酮及其衍生物和定制形式。
• US6492562B1
  申请人：——

  公开号：US6492562B1

  公开（公告）日：2002-12-10
• US7022825B2
  申请人：——

  公开号：US7022825B2

  公开（公告）日：2006-04-04