heptafluoroisopropyl-3-methyl-4-nitrobenzene | 238098-38-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: heptafluoroisopropyl-3-methyl-4-nitrobenzene
• 英文别名: 2-methyl-4-(heptafluoropropan-2-yl)nitrobenzene；2-Methyl-4-(heptafluoropropan-2-yl)-nitrobenzene；4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2-methyl-1-nitrobenzene
• CAS: 238098-38-9
• 化学式: C₁₀H₆F₇NO₂
• 分子量: 305.152
• InChiKey: FHPZIZFWTWOOQW-UHFFFAOYSA-N

物化性质

• 沸点：
  218.2±40.0 °C(Predicted)
• 密度：
  1.481±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  heptafluoroisopropyl-3-methyl-4-nitrobenzene 在 盐酸 、 铁粉 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 以94%的产率得到2-甲基-4-七氟异丙基苯胺
  参考文献：
  名称：

  一种新型Friedel-Crafts反应方法及其催化剂

  摘要：

  本发明涉及通过称为Friedel‑Crafts的反应分别制备或合成酰化或烷基化芳基化合物，例如酰化或烷基化苯的新方法，以及用于该方法的新催化剂。本发明特别涉及用于合成所述酰化或烷基化化合物Friedel‑Crafts反应的新的环保方法。

  公开号：

  CN110776406B
• 作为产物：
  描述：

  氯七氟丙烷 、 甲基硝基苯 在 氢氟酸 、 五氟化锑 作用下， 反应 2.0h， 以97%的产率得到heptafluoroisopropyl-3-methyl-4-nitrobenzene
  参考文献：
  名称：

  一种新型Friedel-Crafts反应方法及其催化剂

  摘要：

  本发明涉及通过称为Friedel‑Crafts的反应分别制备或合成酰化或烷基化芳基化合物，例如酰化或烷基化苯的新方法，以及用于该方法的新催化剂。本发明特别涉及用于合成所述酰化或烷基化化合物Friedel‑Crafts反应的新的环保方法。

  公开号：

  CN110776406B

文献信息

• PHTHALIC ACID DIAMIDE DERIVATIVES FLUORINE-CONTAINING ANILINE COMPOUNDS AS STARTING MATERIAL, AGRICULTURAL AND HORTICULTURAL INSECTICIDES, AND A METHOD FOR APPLICATION OF THE INSECTICIDES
  申请人：——

  公开号：US20010041814A1

  公开（公告）日：2001-11-15

  The present invention provides a phthalic acid diamide derivative represented by the general formula (I) 1 (wherein R 1 , R 2 and R 3 are each H, C 3 -C 6 cycloalkyl group, group of the formula —A 1 —Q l or the like; X may be the same or different and are each halogen atom, nitro group, phenyl group, group of the formula —A 2 —R 7 or the like; n is 1 to 4; Y may be same or different and are each halogen atom, cyano group, phenyl group, group of the formula —A 2 —R 7 or the like; m is 1 to 5; Z 1 and Z 2 are each O or S), fluorine-containing aniline compound represented by the general formula (ST-I) as starting material for said phthalic acid diamide derivative 2 (wherein R a is halogen atom, C 1 -C 6 alkyl group or the like and R b , R c and R d is H or C 2 -C 6 perfluoroalkyl group), and an agricultural and horticultural insecticide containing said phthaldiamide derivative, as well as to provide a method for use of said insecticide. The agricultural and horticultural insecticides of the present invention show excellent activities for controlling injurious insects.

  本发明提供了一种邻苯二甲酰胺衍生物，其由通式（I）1表示（其中R1、R2和R3分别为H、C3-C6环烷基、—A1—Ql或类似基团；X可以相同也可以不同，分别为卤素原子、硝基、苯基、—A2—R7或类似基团；n为1至4；Y可以相同也可以不同，分别为卤素原子、氰基、苯基、—A2—R7或类似基团；m为1至5；Z1和Z2分别为O或S），以通式（ST-I）表示的含氟苯胺化合物作为所述邻苯二甲酰胺衍生物的起始原料2（其中Ra为卤素原子、C1-C6烷基或类似基团，而Rb、Rc和Rd为H或C2-C6全氟烷基），以及含有所述邻苯二甲酰胺衍生物的农业和园艺杀虫剂，同时提供了使用该杀虫剂的方法。本发明的农业和园艺杀虫剂对控制有害昆虫表现出优异的活性。
• Phthalic acid diamide derivatives, fluorine-containing aniline compounds as starting material, agricultural and horticultural insecticides, and a method for application of the insecticides
  申请人：——

  公开号：US20030055287A1

  公开（公告）日：2003-03-20

  The present invention provides a phthalic acid diamide derivative represented by the general formula (I) 1 (wherein R 1 , R 2 and R 3 are each H, C 3 -C 6 cycloalkyl group, group of the formula -A 1 -Q l or the like; X may be the same or different and are each halogen atom, nitro group, phenyl group, group of the formula -A 2 -R 7 or the like; n is 1 to 4; Y may be same or different and are each halogen atom, cyano group, phenyl group, group of the formula -A 2 -R 7 or the like; m is 1 to 5; Z 1 and Z 2 are each O or S), fluorine-containing aniline compound represented by the general formula (ST-I) as starting material for said phthalic acid diamide derivative 2 (wherein R a is halogen atom, C 1 -C 6 alkyl group or the like and R b , R c and R d is H or C 2 -C 6 perfluoroalkyl group), and an agricultural and horticultural insecticide containing said phthaldiamide derivative, as well as to provide a method for use of said insecticide. The agricultural and horticultural insecticides of the present invention show excellent activities for controlling injurious insects.

  本发明提供了一种邻苯二甲酰胺衍生物，其表示为通式（I）1（其中R1、R2和R3分别为H、C3-C6环烷基、-A1-Ql或类似基团；X可以相同或不同，分别为卤素原子、硝基、苯基、-A2-R7或类似基团；n为1至4；Y可以相同或不同，分别为卤素原子、氰基、苯基、-A2-R7或类似基团；m为1至5；Z1和Z2分别为O或S），以及以含氟苯胺化合物为起始物质的邻苯二甲酰胺衍生物2（其中Ra为卤素原子、C1-C6烷基或类似基团，而Rb、Rc和Rd为H或C2-C6全氟烷基），以及包含所述邻苯二甲酰胺衍生物的农业和园艺杀虫剂，同时提供了使用所述杀虫剂的方法。本发明的农业和园艺杀虫剂表现出优异的控制有害昆虫的活性。
• Fluorine-containing aniline compounds
  申请人：NIHON NOHYAKU CO., LTD.

  公开号：EP0936212A1

  公开（公告）日：1999-08-18

  The present invention provides a novel fluorine-containing aniline compound represented by the general formula (I): (wherein R1 is a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group or a trifluoromethyl group, and each of R2, R3 and R4 is H or a C2-C6 perfluoroalkyl group, provided that at least one of R2, R3 and R4 is not H; that R3 is neither a pentafluoroethyl group nor a n-heptafluoropropyl group, when R1 is F and each of R2 and R4 is H; and that R3 is not a pentafluoroethyl group, when R1 is a methyl group and each of R2 and R4 is H), which is useful as an intermediate of a medicine, agrochemical, chemical product, etc.

  本发明提供了通式(I)代表的新型含氟苯胺化合物： (其中 R1 是卤原子、C1-C6 烷基、C1-C6 烷氧基或三氟甲基，R2、R3 和 R4 各为 H 或 C2-C6 全氟烷基，条件是 R2、R3 和 R4 中至少有一个不是 H；当 R1 为 F 且 R2 和 R4 中的每一个均为 H 时，R3 既不是五氟乙基，也不是正七氟丙基；当 R1 为甲基且 R2 和 R4 中的每一个均为 H 时，R3 不是五氟乙基），可用作药物、农用化学品、化工产品等的中间体。
• PROCESS FOR FRIEDEL-CRAFTS REACTION, AND CATALYST THEREFORE
  申请人：Fujian Yongjing Technology Co., Ltd.

  公开号：EP3696157A1

  公开（公告）日：2020-08-19

  The invention relates to a new process for the manufacture or synthesis, respectively, of acylated or alkylated aryl compounds, for example, acylated or alkylated benzenes, by the so-called Friedel-Crafts reaction, and a new catalyst therefore.. The present invention particularly pertains to a novel environmentally friendly process for the synthesis of the said acylated or alkylated compounds Friedel-Crafts reaction.

  本发明涉及一种通过所谓的弗里德尔-卡夫斯反应分别制造或合成酰化或烷化芳基化合物（例如酰化或烷化苯）的新工艺，以及因此而产生的一种新催化剂。本发明尤其涉及一种新型环保工艺，用于合成上述酰化或烷基化化合物的弗里德尔-卡夫斯反应。
• Process for Friedel-Crafts Reaction, and Catalyst Therefore
  申请人：Fujian Yongjing Technology Co., Ltd.

  公开号：US20200262775A1

  公开（公告）日：2020-08-20

  The invention relates to a new process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly production of the said compounds. Thus, the present invention overcomes the disadvantages of the prior art processes, and in a surprisingly simple and beneficial manner, and as compared to the prior art processes, in particular, the invention provides a more efficient and energy saving processes, and also provides a more environmentally friendly process, for the manufacture of nuclear fluorinated aromatics, and preferably of nuclear fluorinated fluorobenzenes. Accordingly, in one aspect of the invention, an industrially beneficial process for preparing fluorobenzenes from halobenzene precursors using HF to form hydrogen halide is provided by the present invention. A beneficial and surprisingly simple use of chlorobenzene as an industrially interesting starting material in the manufacture of fluorobenzene is provided.