4-tert-Butoxycarbonylamino-butyric acid benzotriazol-1-yl ester | 515137-25-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-tert-Butoxycarbonylamino-butyric acid benzotriazol-1-yl ester
• 英文别名: Benzotriazol-1-yl 4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate
• CAS: 515137-25-4
• 化学式: C₁₅H₂₀N₄O₄
• 分子量: 320.348
• InChiKey: QJTJDVPGHDREQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  95.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-tert-Butoxycarbonylamino-butyric acid benzotriazol-1-yl ester 在 sodium hydroxide 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 生成 4-(4-Tert-butoxycarbonylaminobutyrylamino)-1-methyl-1h-imidazole-2-carboxylic acid
  参考文献：
  名称：

  Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids

  摘要：

  The solid phase synthesis of sequence specific DNA binding polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids is described. Two monomer building blocks, Boc-Py-OBt ester and Boc-Im acid, are prepared on a 50 g scale without column chromatography. Using commercially available Boc-beta-alanine-Pam resin, cycling protocols were optimized to afford high stepwise coupling yields (>99%). Deprotection by aminolysis affords up to 100 mg quantities of polyamide. Solid phase methodology increases both the number and complexity of minor groove binding polyamides which can be synthesized and analyzed with regard to DNA binding affinity and sequence specificity. The solid phase synthesis of a representative eight-residue polyamide is reported.

  DOI：

  10.1021/ja960720z
• 作为产物：
  描述：

  N-BOC-GAMMA-氨基丁酸 、 1-羟基苯并三唑 在 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 4-tert-Butoxycarbonylamino-butyric acid benzotriazol-1-yl ester
  参考文献：
  名称：

  Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids

  摘要：

  The solid phase synthesis of sequence specific DNA binding polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids is described. Two monomer building blocks, Boc-Py-OBt ester and Boc-Im acid, are prepared on a 50 g scale without column chromatography. Using commercially available Boc-beta-alanine-Pam resin, cycling protocols were optimized to afford high stepwise coupling yields (>99%). Deprotection by aminolysis affords up to 100 mg quantities of polyamide. Solid phase methodology increases both the number and complexity of minor groove binding polyamides which can be synthesized and analyzed with regard to DNA binding affinity and sequence specificity. The solid phase synthesis of a representative eight-residue polyamide is reported.

  DOI：

  10.1021/ja960720z

文献信息

• OLIGOAMINE COMPOUNDS AND DERIVATIVES THEREOF FOR CANCER THERAPY
  申请人：Frydman Benjamin

  公开号：US20090124832A1

  公开（公告）日：2009-05-14

  Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.

  提供具有抗癌和抗增殖活性的寡胺化合物，以及制备和使用这些化合物的方法。这些化合物已被证明对前列腺癌细胞系和小鼠前列腺癌肿瘤具有活性。这些化合物还可用于治疗乳腺癌和其他癌症。
• US7491849B2
  申请人：——

  公开号：US7491849B2

  公开（公告）日：2009-02-17
• Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids
  作者：Eldon E. Baird、Peter B. Dervan

  DOI：10.1021/ja960720z

  日期：1996.1.1

  The solid phase synthesis of sequence specific DNA binding polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids is described. Two monomer building blocks, Boc-Py-OBt ester and Boc-Im acid, are prepared on a 50 g scale without column chromatography. Using commercially available Boc-beta-alanine-Pam resin, cycling protocols were optimized to afford high stepwise coupling yields (>99%). Deprotection by aminolysis affords up to 100 mg quantities of polyamide. Solid phase methodology increases both the number and complexity of minor groove binding polyamides which can be synthesized and analyzed with regard to DNA binding affinity and sequence specificity. The solid phase synthesis of a representative eight-residue polyamide is reported.
• Discovery of a Series of 5-Amide-1<i>H</i>-pyrazole-3-carboxyl Derivatives as Potent P2Y₁₄R Antagonists with Anti-Inflammatory Characters
  作者：Yu-hang Wang、Meng-ze Zhou、Tao Ye、Ping-ping Wang、Ran Lu、Yi-lin Wang、Chun-xiao Liu、Wen Xiao、Jia-yi Li、Zi-bo Meng、Li-li Xu、Qing-hua Hu、Cheng Jiang

  DOI：10.1021/acs.jmedchem.2c01632

  日期：2022.12.8