7-amino-3-methylcoumarin | 74981-11-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-amino-3-methylcoumarin
• 英文别名: 7-amino-3-methyl-coumarin；7-Amino-3-methyl-2H-chromen-2-one；7-amino-3-methylchromen-2-one
• CAS: 74981-11-6
• 化学式: C₁₀H₉NO₂
• 分子量: 175.187
• InChiKey: HRNOIAOFVVUYJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-amino-3-methylcoumarin 、 苄氧羰基-L-丙氨酸 在 N-甲基吗啉 、 1-丙基磷酸酐 作用下， 以 乙酸乙酯 、 乙腈 为溶剂， 反应 0.17h， 以70%的产率得到Z-Ala-7-amino-3-methylcoumarin amide
  参考文献：
  名称：

  通过T3P激活高效且无差向异构合成衍生自α-氨基酸和肽酸的C末端芳基酰胺

  摘要：

  高产量和对映体纯快速合成Ñ α -保护的氨基/肽使用酸芳基酰胺Ñ在存在-propylphosphonic酸酐（T3P）ñ甲基吗啉进行说明。该反应的一般性已经研究了各种Ñ α -保护的氨基酸与不同范围的芳族胺和香豆素衍生物。

  DOI：

  10.1007/s10989-013-9383-7

文献信息

• [EN] NA-ACYL DERIVATIVES OF AMINOACYL-2-CYANOPYRROLIDINE-INHIBITORS OF PROLYL ENDOPEPTIDASE AND DIPEPTIDYL PEPTIDASE-IV, HAVING HYPOGLYCEMIC, ANTIHYPOXIC, NEUROPROTECTIVE ACTION AND ACTION OF COGNITIVE FUNCTION IMPROVEMENT<br/>[FR] DÉRIVÉS NA-ACYLE D'AMINOACYL-2-CYANOPYRROLIDINE INHIBANT LA PROLYL ENDOPEPTIDASE ET LA DIPEPTIDYL PEPTIDASE-IV, PRÉSENTANT UNE ACTION HYPOGLYCÉMIQUE, ANTIHYPOXIQUE ET NEUROPROTECTRICE ET AMÉLIORANT LES FONCTIONS COGNITIVES
  申请人：DAPHOT ENTERPRAISES LTD

  公开号：WO2014054980A1

  公开（公告）日：2014-04-10

  The subject of the present invention is nα-acyl derivatives of aminoacyl-2-cyanopyrrolidine - inhibitors of prolyl endopeptidase and dipeptidyl peptidase-iv, having hypoglycemic, antihypoxic, neuroprotective action and action of cognitive function improvement.

  本发明的主题是氨酰基-2-氰基吡咯烷的nα-酰基衍生物 - 脯氨酸内切肽酶和二肽基肽酶-IV的抑制剂，具有降糖、抗缺氧、神经保护作用和改善认知功能的作用。
• Fluorophore-containing compounds and their use in the detection of phosphorylated (poly)peptides
  申请人：Universität Regensburg

  公开号：EP2233485A1

  公开（公告）日：2010-09-29

  The present invention relates to certain fluorophor compounds and a method of detecting a phosphorylated peptide or phosphorylated polypeptide using the same. Furthermore, a method of detecting and differentiating phosphorylated and unphosphorylated peptides or polypeptides is described. A kit and a diagnostic composition comprising the fluorophor compounds as well as a method of diagnosing a disease are also disclosed.

  本发明涉及某些荧光物质化合物以及使用这些化合物检测磷酸化肽或磷酸化多肽的方法。此外，还描述了一种检测和区分磷酸化和未磷酸化肽或多肽的方法。还公开了一种包含荧光物质化合物的试剂盒和诊断组合物，以及一种诊断疾病的方法。
• Fluorescent bis-coumarins for organic light-emitting devices
  申请人：Canon Inc.

  公开号：US06770385B2

  公开（公告）日：2004-08-03

  A fluorescent compound, suitable for use in an active layer of an organic light-emitting device and exhibiting both good luminescence and excellent thermal stability, which has the structure wherein R is substituted or unsubstituted alkyl; wherein Ar2 is optionally present; and wherein Ar1, Ar2, and Ar3 are independently each a substituted or unsubstituted aryl group.

  一种荧光化合物，适用于有机发光器件的活性层，并且具有良好的发光性能和优异的热稳定性，其结构为R被取代或未取代的烷基；其中Ar2是可选的；而Ar1、Ar2和Ar3是各自独立的被取代或未取代的芳基基团。
• Device for enhancing fluorescence and kinetics and methods of using the device
  申请人：Becton Dickinson and Company

  公开号：EP0347771A2

  公开（公告）日：1989-12-27

  A carrier having at least one kinetics and fluorescence enhancing support and a dry substance selected from the group consisting of fluorogenic substrates, B-methylumbelliferone, 7-amino-4-methyl coumarin, B-napthylamine, fluoroscein, and resorufin deposited on the support demonstrates substantial enhancement of hydrolysis kinetics and fluorescence over pure liquid systems. When the device has a plurality of supports and the supports have different fluorogenic substrates an enzyme rate-of-reaction profile representative of a microorganism in the suspension can be determined and used to identify the organism. The device can also be used to characterize enzymes expressed by other biological specimens.

  一种载体具有至少一种动力学和荧光增强支持物，以及一种选自含氟底物、B-甲基伞形酮、7-氨基-4-甲基香豆素、B-萘胺、荧光素和resorufin 所组成的组的干物质，沉积在支持物上，与纯液体系统相比，该载体的水解动力学和荧光得到了极大的增强。当该装置具有多个支持物，且支持物具有不同的荧光底物时，可确定悬浮液中微生物的酶反应速率曲线，并用于识别该微生物。该装置还可用于鉴定其他生物样本表达的酶。
• PARTICLE FOR ENZYMATIC ACTIVITY DETECTION AND, UTILIZING THE SAME, METHOD OF ENZYMATIC ACTIVITY DETECTION AND ENZYMATIC ACTIVITY DETECTION TOOL
  申请人：Kyushu Institute of Technology

  公开号：EP1845155A1

  公开（公告）日：2007-10-17

  An object is to provide a particle for detecting an enzyme activity wherein by measuring an intensity of a fluorescence wavelength in a sample solution, it is possible to not only detect the presence or absence of an enzyme but also accurately perform a quantitative analysis of the enzyme in the sample solution, handleability is excellent as well as measurement accuracy and quantitative property can be enhanced because the present invention is hardly influenced by absorbed moisture and weighing errors hardly occur, and further productivity is remarkably excellent because complicated steps such as a step of cleaving and purifying a synthesized peptide and a step of lyophilizing are not required upon production thereof. The particle 1 for detecting the enzyme activity of the present invention comprises a particle 2 and a first compound 3 binding the particle 2 to one end, binding a first fluorescent group 4 to the other end and having a cleavage site by an enzyme 5 in a sample solution. A particle formed of a synthetic resin or an inorganic material and having a constant surface area per unit weight

  本发明的目的是提供一种用于检测酶活性的颗粒，通过测量样品溶液中荧光波长的强度，不仅可以检测酶的存在与否，还可以准确地对样品溶液中的酶进行定量分析、由于本发明几乎不受吸收水分的影响，几乎不会出现称量误差，因此操作性极佳，测量精度和定量性能也能得到提高；由于生产时不需要裂解和纯化合成肽以及冻干等复杂步骤，因此生产率也显著提高。 本发明用于检测酶活性的微粒 1 包括微粒 2 和一端与微粒 2 结合、另一端与第一荧光基团 4 结合并在样品溶液中具有被酶 5 裂解位点的第一化合物 3。 由合成树脂或无机材料形成的颗粒，单位重量的表面积恒定