2-methyl-3,4-diphenylpyridine | 55222-33-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-methyl-3,4-diphenylpyridine
• CAS: 55222-33-8
• 化学式: C₁₈H₁₅N
• 分子量: 245.324
• InChiKey: CMHLHJWEOZSKFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-苯基-1-丙炔 在 bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 氘代苯 、 二甲基亚砜 为溶剂， 反应 43.0h， 生成 2-methyl-3,4-diphenylpyridine
  参考文献：
  名称：

  N-杂环合成的一锅顺序加氢胺化方案：一种获得五种不同类别三取代吡啶的方法

  摘要：

  三取代吡啶是重要的支架，可在大量市售药物中找到。描述了一种用于选择性合成较少探索/具有挑战性的三取代吡啶模式的一锅通用方法。炔烃与市售N-三苯基甲硅烷基胺的加氢胺化生成N-甲硅烷基胺。这些原位生成的N-甲硅烷基胺与 α,β-不饱和羰基化合物反应并随后氧化，提供 25 个选择性取代的 2,4,5-、2,3,4-、3,4,5-、2,3,5- 实例, 和 2,3,6-三取代吡啶，收率高达 78%。该反应具有高官能团相容性，为选择性取代的三取代吡啶衍生物的组装提供了一种快速且通用的方法。该反应的稳健性和实用性已在克级反应中得到证明。

  DOI：

  10.1021/acs.joc.2c02155

文献信息

• [EN] MELPHALAN PRODRUGS<br/>[FR] PROMEDICAMENTS DE MELPHALAN
  申请人：SEATTLE GENETICS INC

  公开号：WO2005070457A1

  公开（公告）日：2005-08-04

  Shown and described are the synthesis of more potent forms of C-Mel, a prodrug used in Antibody-Directed Enzyme Prodrug Therapy, that releases the clinically used anticancer alkylating agent melphalan extracellularly. Shown and described are the synthesis of a variety of melphalan analogues with the intention to promote facile intracellular drug access. Esters, amides, and peptides of melphalan are shown. Cephalosporin prodrugs of the most interesting melphalan derivatives were synthesized and evaluated for potency, toxicity, therapeutic window, plasma stability, and solubility.

  所示和描述的是更强效的C-Mel形式的合成，这是一种用于抗体导向酶前药治疗的前药，该前药在胞外释放临床使用的抗癌烷化剂梅法仑。所示和描述的是合成各种梅法仑类似物，旨在促进细胞内药物易进入。显示了梅法仑的酯、酰胺和肽。合成并评估了最有趣的梅法仑衍生物的头孢菌素前药，以评估其效力、毒性、治疗窗口、血浆稳定性和溶解度。
• Organic electroluminescence device
  申请人：UDC Ireland

  公开号：US10454042B2

  公开（公告）日：2019-10-22

  An object of the present invention is to provide an organic electroluminescence device having excellent light emission efficiency and durability, in particular, durability when driving at a high temperature. Provided is an organic electroluminescence device including on a substrate a pair of electrodes, and at least one layer of an organic layer including a light emitting layer containing a light emitting material disposed between the electrodes, wherein the light emitting layer includes at least each one of specific indolocarbazole derivatives and specific condensed ring metal complexes.

  本发明的目的是提供一种有机电致发光器件，该器件具有优异的发光效率和耐用性，特别是在高温驱动时的耐用性。本发明提供了一种有机电致发光器件，包括在基底上的一对电极，以及至少一层有机层，该有机层包括设置在电极之间的包含发光材料的发光层，其中发光层包括特定吲哚咔唑衍生物和特定缩合环金属配合物中的至少一种。
• COMPOUND FOR ORGANIC ELECTROLUMINESCENT ELEMENT AND ORGANIC ELECTROLUMINESCENT ELEMENT
  申请人：Nippon Steel Chemical Co., Ltd.

  公开号：EP1956022B1

  公开（公告）日：2012-07-25
• Compound for Use in Organic Electroluminescent Device and Organic Electroluminescent Device
  申请人：Komori Masaki

  公开号：US20090302742A1

  公开（公告）日：2009-12-10

  Disclosed are an organic electroluminescent device (organic EL device) which is improved in luminous efficiency, fully secured of driving stability, and simple in constitution and a compound for use therein. The organic electroluminescent device comprises a light-emitting layer disposed between an anode and a cathode piled one upon another on a substrate and the light-emitting layer contains a phosphorescent dopant and a compound for use in an organic electroluminescent device having two or more indolocarbazole skeletons as a host material. An example of the compound having indolocarbazole skeletons for use in the device is expressed by the following formula.
• ORGANIC ELECTROLUMINESCENCE DEVICE
  申请人：Fukuzaki Eiji

  公开号：US20120153272A1

  公开（公告）日：2012-06-21

  An object of the present invention is to provide an organic electroluminescence device having excellent light emission efficiency and durability, in particular, durability when driving at a high temperature. Provided is an organic electroluminescence device including on a substrate a pair of electrodes, and at least one layer of an organic layer including a light emitting layer containing a light emitting material disposed between the electrodes, wherein the light emitting layer includes at least each one of specific indolocarbazole derivatives and specific condensed ring metal complexes.