1,3-dimethyl-5,6-dinitro-1,3-dihydro-benzoimidazol-2-one | 90324-08-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1,3-dimethyl-5,6-dinitro-1,3-dihydro-benzoimidazol-2-one
• 英文别名: 1,3-dimethyl-5,6-dinitro-1,3-dihydro-benzimidazol-2-one；1,3-Dimethyl-5,6-dinitro-1,3-dihydro-benzimidazol-2-on；5.6-Dinitro-1.3-dimethyl-3H-benzimidazolon-(2)；1,3-dimethyl-5,6-dinitro-1,3-dihydro-2H-benzimidazol-2-one；1,3-dimethyl-5,6-dinitrobenzimidazol-2-one
• CAS: 90324-08-6
• 化学式: C₉H₈N₄O₅
• 分子量: 252.186
• InChiKey: UYJIIRQCHSTSRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3-dimethyl-5,6-dinitro-1,3-dihydro-benzoimidazol-2-one 在 盐酸 、 tin 、 水 作用下， 生成 5,6-diamino-1,3-dimethyl-1,3-dihydro-benzimidazol-2-one
  参考文献：
  名称：

  Lower Body Function and Mortality in Mexican American Elderly People

  摘要：

  Background. The purpose of this analysis was to examine the differential impact of performance-based and self-reported lower body measures on 2-year mortality in Mexican American elderly persons.Methods. Data employed are from the Hispanic Established Population for Epidemiological Studies of the Elderly, a probability survey of 3050 community-dwelling Mexican Americans aged 65 and older from the five Southwestern states interviewed in 1993 and 1994. Of the baseline sample with complete data. 198 persons were confirmed deceased 2 years later. A three-task, performance-based. lower body function measure consisting of a short walk, balance. and repeated chair stands tests was used. Self-reported lower body function was measured by a 4-item Activities of Daily Living (ADL) measure involving the lower body.Results. The three-task. lower body function measure was a significant predictor of 2-year mortality. The short walk alone was as predictive as the summary measure. The predictive ability of both measures was minimally reduced by the inclusion of the self-reported ADL measure and life-threatening medical conditions. Finally. the ADL measure was not a significant predictor of mortality with all the other variables in the analysis.Conclusion. Objective measures of lower body function were significant predicators of mortality in Mexican American elderly persons, as found in the general population. Unlike previous studies, the ADL measure was not an independent predictor of mortality after controlling for the objective measure and other risk factors. Additional research is needed to address why objective measures of function are such strong predictors of death.

  DOI：

  10.1093/gerona/56.4.m243
• 作为产物：
  描述：

  2-羟基苯并咪唑 在 alkaline solution 、 硫酸 、 硝酸 作用下， 生成 1,3-dimethyl-5,6-dinitro-1,3-dihydro-benzoimidazol-2-one
  参考文献：
  名称：

  Efros; El'zow, Zhurnal Obshchei Khimii, 1957, vol. 27, p. 127,130; engl. Ausg. S. 143, 147

  摘要：

  DOI：

文献信息

• History and Mobility Exam Index to Identify Community-Dwelling Elderly Persons at Risk of Falling
  作者：K. E. Covinsky、E. Kahana、B. Kahana、K. Kercher、J. G. Schumacher、A. C. Justice

  DOI：10.1093/gerona/56.4.m253

  日期：2001.4.1

  Background. Falls are common in community-dwelling elderly persons and are a frequent source of morbidity. Simple indices to prospectively stratify people into categories at different fall-risk would be useful to health care practitioners. Our goal was to develop a fall-risk index that discriminated between people at high and low risk of falling.Methods. We evaluated the risk of falling over a one-year period in 557 elderly persons (mean age 81.6) living in a retirement community. On the baseline interview, we asked subjects if they had fallen in the previous year and evaluated risk factors in six additional conceptual categories. On the follow-up interview. one year later, we again asked subjects if they had fallen in the prior year. We evaluated risk factors in the different conceptual categories and used logistic regression to determine: the independent predictors of falling over a one-year period. We used these independent predictors to create a fall-risk index. We compared the ability of a prior falls history with other risk factors and with the combination of a falls history and other risk factors to discriminate fallers from nonfallers.Results. A fall in the previous year (OR = 2.42, 95% Cl = 1.49-3.93). a symptom of either balance difficulty or dirtiness (OR = 1.83. 95% CI = 1.16-2.89). or an abnormal mobility exam (OR = 2.61. 95% CI = 1.64-4.26) were independent predictors of falling over the subsequent year. These three risk factors together (L statistic = .71) discriminated fallers from nonfallers better than previous history of falls alone (e statistic = .61) or the symptomatic and exam risk factors alone ( statistic = .68). When combined into a risk index, the three independent risk factors stratify people into groups whose risk for falling over the subsequent year ranges from 10% to 51%.Conclusion, A history of falling over the prior year, a risk factor that can be obtained from a clinical history (balance difficulty or dizziness), and a risk factor that can be obtained from a physical exam (mobility difficulty) stratify people into groups at low and high risk of falling over the subsequent year. This risk index may provide a simple method of assessing fall risk in community-dwelling elderly persons. However, it requires validation in other subjects before it can be recommended for widespread use.
• Lower Body Function and Mortality in Mexican American Elderly People
  作者：K. S. Markides、S. A. Black、G. V. Ostir、R. J. Angel、J. M. Guralnik、M. Lichtenstein

  DOI：10.1093/gerona/56.4.m243

  日期：2001.4.1

  Background. The purpose of this analysis was to examine the differential impact of performance-based and self-reported lower body measures on 2-year mortality in Mexican American elderly persons.Methods. Data employed are from the Hispanic Established Population for Epidemiological Studies of the Elderly, a probability survey of 3050 community-dwelling Mexican Americans aged 65 and older from the five Southwestern states interviewed in 1993 and 1994. Of the baseline sample with complete data. 198 persons were confirmed deceased 2 years later. A three-task, performance-based. lower body function measure consisting of a short walk, balance. and repeated chair stands tests was used. Self-reported lower body function was measured by a 4-item Activities of Daily Living (ADL) measure involving the lower body.Results. The three-task. lower body function measure was a significant predictor of 2-year mortality. The short walk alone was as predictive as the summary measure. The predictive ability of both measures was minimally reduced by the inclusion of the self-reported ADL measure and life-threatening medical conditions. Finally. the ADL measure was not a significant predictor of mortality with all the other variables in the analysis.Conclusion. Objective measures of lower body function were significant predicators of mortality in Mexican American elderly persons, as found in the general population. Unlike previous studies, the ADL measure was not an independent predictor of mortality after controlling for the objective measure and other risk factors. Additional research is needed to address why objective measures of function are such strong predictors of death.
• Efros; El'zow, Zhurnal Obshchei Khimii, 1957, vol. 27, p. 127,130; engl. Ausg. S. 143, 147
  作者：Efros、El'zow

  DOI：——

  日期：——