(2Z)-2-(4-nitrobenzylidene)-2,3-dihydro-1H-inden-1-one | 59082-28-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (2Z)-2-(4-nitrobenzylidene)-2,3-dihydro-1H-inden-1-one
• 英文别名: 2-(4-nitrobenzylidene)indan-1-one；(Z)-2-p-Nitrobenzyliden-1-indanon；2-(4-(Hydroxy(oxido)amino)benzylidene)-1-indanone；(2Z)-2-[(4-nitrophenyl)methylidene]-3H-inden-1-one
• CAS: 59082-28-9
• 化学式: C₁₆H₁₁NO₃
• 分子量: 265.268
• InChiKey: ALIVNIMDJGLSCR-LCYFTJDESA-N

物化性质

• 沸点：
  443.3±45.0 °C(Predicted)
• 密度：
  1.362±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 、 1-茚酮 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以87.6%的产率得到(2Z)-2-(4-nitrobenzylidene)-2,3-dihydro-1H-inden-1-one
  参考文献：
  名称：

  Inhibitory kinetics of novel 2,3-dihydro-1 H -inden-1-one chalcone-like derivatives on mushroom tyrosinase

  摘要：

  In this study, novel 2,3-dihydro-1H-inden-1-one chalcone-like compounds and their hydroxyl derivatives were synthesized, and their inhibitory effects on mushroom tyrosinase activity were evaluated. Two of the compounds synthesized inhibited the diphenolase activity of tyrosinase in a dose dependent manner and exhibited much higher tyrosinase inhibitory activities (IC50 values of 12.3 mu M and 8.2 mu M, respectively) than the positive control, kojic acid (IC50: 27.5 mu M). Kinetic analysis showed that their inhibition was reversible. Both the novel compounds displayed competitive inhibition with their K-i values of 10.3 mu M and 8.7 mu M, respectively. This study suggests hydroxy substituted 2,3-dihydro-1H-inden-1-one chalcone-like compounds to serve as promising candidates for use as depigmentation agents. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.10.071

文献信息

• Tricyclic pyrazole derivatives
  申请人：BASF Aktiengesellschaft

  公开号：US06462036B1

  公开（公告）日：2002-10-08

  This invention relates to certain 3-aryl or 3-heteroaryl pyrazoles with 4,5(3,4)-bicyclic ring fusion which are inhibitors of protein kinase activity, of which some are novel compounds, to pharmaceutical compositions containing these pyrazoles and to processes for preparing these pyrazoles.

  这项发明涉及具有4,5(3,4)-双环融合的3-芳基或3-杂芳基吡唑，这些化合物是蛋白激酶活性抑制剂，其中一些是新颖化合物，涉及含有这些吡唑的药物组合物以及制备这些吡唑的方法。
• Therapeutic agents
  申请人：BASF Aktiengesellschaft

  公开号：US06297238B1

  公开（公告）日：2001-10-02

  This invention realtes to compounds formula I and pharmaceutically acceptable salts thereof, which are inhibitors of protein kinase activity, pharmaceutical compositions thereof and provesses for their preparation.

  这项发明涉及公式I的化合物及其药物可接受的盐，它们是蛋白激酶活性的抑制剂，以及它们的制药组合物和制备过程。
• SUBSTITUTED 1,4-DIHYDROINDENO[1,2-C]PYRAZOLES AS INHIBITORS OF TYROSINE KINASE
  申请人：Knoll GmbH

  公开号：EP1165544B1

  公开（公告）日：2003-08-06
• INHIBITORS OF PROTEIN KINASES
  申请人：Knoll GmbH

  公开号：EP1268437A1

  公开（公告）日：2003-01-02
• US6297238B1
  申请人：——

  公开号：US6297238B1

  公开（公告）日：2001-10-02