2-imidazol-1-ylmethyl-indan-1-one | 1093231-50-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-imidazol-1-ylmethyl-indan-1-one
• 英文别名: 2-(Imidazol-1-ylmethyl)indan-1-one；2-(imidazol-1-ylmethyl)-2,3-dihydroinden-1-one
• CAS: 1093231-50-5
• 化学式: C₁₃H₁₂N₂O
• 分子量: 212.251
• InChiKey: SFUAEPNPGRYJPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-hydroxymethyl-2-imidazol-1-ylmethyl-indan-1-one 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 以100%的产率得到2-imidazol-1-ylmethyl-indan-1-one
  参考文献：
  名称：

  Proline-catalyzed facile access to Mannich adducts using unsubstituted azoles

  摘要：

  A novel and facile method for the direct construction of C-C-N bond with unsubstituted azoles under Mannich conditions is developed for the first time. The reaction is catalyzed efficiently by.-proline to give the Mannich adducts 1a-10b in DMSO, whereas in water, insertion of two successive bonds, C-C-N and C-C-O occurred to give compounds 11a-20b. The latter are deformylated readily into the desired products 1a-10b Under basic conditions. Mechanistic aspects for the formation of these products are discussed. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.155

文献信息

• Proline-catalyzed facile access to Mannich adducts using unsubstituted azoles
  作者：Nagarapu Srinivas、Kalpana Bhandari

  DOI：10.1016/j.tetlet.2008.09.155

  日期：2008.12

  A novel and facile method for the direct construction of C-C-N bond with unsubstituted azoles under Mannich conditions is developed for the first time. The reaction is catalyzed efficiently by.-proline to give the Mannich adducts 1a-10b in DMSO, whereas in water, insertion of two successive bonds, C-C-N and C-C-O occurred to give compounds 11a-20b. The latter are deformylated readily into the desired products 1a-10b Under basic conditions. Mechanistic aspects for the formation of these products are discussed. (c) 2008 Elsevier Ltd. All rights reserved.