2,4-Bis[(2,4-dimethylphenoxy)methyl]-1-propoxybenzene | 1253261-56-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,4-Bis[(2,4-dimethylphenoxy)methyl]-1-propoxybenzene
• 英文别名: 2,4-bis[(2,4-dimethylphenoxy)methyl]-1-propoxybenzene
• CAS: 1253261-56-1
• 化学式: C₂₇H₃₂O₃
• 分子量: 404.549
• InChiKey: GAJUFESBJJGTOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4-bis(2,4-dimethylphenoxymethyl)allyloxybenzene 在 sodium tetrahydroborate 、 palladium on carbon 作用下， 以 四氢呋喃 为溶剂， 以70%的产率得到2,4-二甲基苯酚
  参考文献：
  名称：

  Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation

  摘要：

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.

  DOI：

  10.1021/ol102081q

文献信息

• Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation
  作者：Nathan W. Polaske、Michael L. Szalai、Charles S. Shanahan、Dominic V. McGrath

  DOI：10.1021/ol102081q

  日期：2010.11.5

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.