1-[[5-[[2,4-Bis[(2,4-dimethylphenoxy)methyl]phenoxy]methyl]-2-propoxyphenyl]methoxy]-2,4-bis[(2,4-dimethylphenoxy)methyl]benzene | 1253261-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-[[5-[[2,4-Bis[(2,4-dimethylphenoxy)methyl]phenoxy]methyl]-2-propoxyphenyl]methoxy]-2,4-bis[(2,4-dimethylphenoxy)methyl]benzene
• 英文别名: 1-[[5-[[2,4-bis[(2,4-dimethylphenoxy)methyl]phenoxy]methyl]-2-propoxyphenyl]methoxy]-2,4-bis[(2,4-dimethylphenoxy)methyl]benzene
• CAS: 1253261-58-3
• 化学式: C₅₉H₆₄O₇
• 分子量: 885.153
• InChiKey: HYAHLNNYIGVHQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.5
• 重原子数：
  66
• 可旋转键数：
  21
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,4-bis(2,4-bis(2,4-dimethylphenoxymethyl)phenoxymethyl)allyloxybenzene 在 sodium tetrahydroborate 、 palladium on carbon 作用下， 以 四氢呋喃 为溶剂， 以80%的产率得到2,4-二甲基苯酚
  参考文献：
  名称：

  Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation

  摘要：

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.

  DOI：

  10.1021/ol102081q

文献信息

• Convergent Synthesis of Geometrically Disassembling Dendrimers using Cu(I)-Catalyzed C−O Bond Formation
  作者：Nathan W. Polaske、Michael L. Szalai、Charles S. Shanahan、Dominic V. McGrath

  DOI：10.1021/ol102081q

  日期：2010.11.5

  The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl iodides and alcohols. The synthesis and disassembly of these compounds is discussed.