2-(2-hydroxy-6-methylphenyl)acetic acid | 38692-76-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-hydroxy-6-methylphenyl)acetic acid
• CAS: 38692-76-1
• 化学式: C₉H₁₀O₃
• 分子量: 166.177
• InChiKey: XVMJVOYXXOQPHK-UHFFFAOYSA-N

物化性质

• 熔点：
  110.5 °C
• 沸点：
  343.4±27.0 °C(Predicted)
• 密度：
  1.262±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-hydroxy-6-methylphenyl)acetic acid 生成 4-methylbenzofuran-2(3H)-one
  参考文献：
  名称：

  Aubert et al., Acta Chemica Scandinavica (1947), 1952, vol. 6, p. 433,438

  摘要：

  DOI：
• 作为产物：
  描述：

  2-羟基-6-甲基苯甲酸 在 palladium on activated charcoal sodium hydroxide 、 sodium tetrahydroborate 、 氯化亚砜 、 四丁基溴化铵 、 氢气 、 三溴化磷 、 N,N-二甲基甲酰胺 作用下， 以 乙醇 、 二氯甲烷 、 二乙二醇二甲醚 、 水 、 苯 为溶剂， 生成 2-(2-hydroxy-6-methylphenyl)acetic acid
  参考文献：
  名称：

  Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo

  摘要：

  In a search for compounds related to flavoneacetic acid with activity against solid tumors, a series of methyl-, methoxy-, chloro-, nitro-, and hydroxy-substituted xanthenone-4-acetic acids have been synthesized and evaluated against subcutaneously implanted colon adenocarcinoma 38 in vivo, using a short-term histology assay as a primary screening system. A major goal of this work was to identify compounds with similar profiles of activity to that of flavoneacetic acid but of higher potency. The level of activity of the compounds appeared to depend more on the nature of the substituent than its positioning, in the order Cl greater than Me, OMe greater than NO2, OH. However, the potency of the compounds was related much more to the position rather than the nature of the substitution, with 5-substituted compounds being clearly the most dose potent. 5-Methylxanthenone-4-acetic acid has a similar level of activity to that of flavoneacetic acid in the test systems employed but is more than 7-fold as dose potent.

  DOI：

  10.1021/jm00124a012

文献信息

• POLYCARBONATE RESIN COMPOSITION AND FORMED PRODUCT THEREOF
  申请人：Monden Toshiki

  公开号：US20110245388A1

  公开（公告）日：2011-10-06

  In a polycarbonate resin composition containing a polycarbonate resin and a polycarbosilane compound, the use of the polycarbosilane compound modifies the surface properties of the polycarbonate resin composition without adversely affecting the intrinsic characteristics of the polycarbonate resin, such as transparency, heat resistance, and mechanical properties, e.g., impact resistance. A polycarbonate resin composition containing 100 parts by mass of a polycarbonate resin, 0.001 to 1 part by mass of a metal salt compound, and 0.005 to 5 parts by mass of a polycarbosilane compound has significantly improved flame resistance and high transparency and causes markedly reduced outgassing and mold fouling, without losing impact resistance and heat resistance.

  在含有聚碳酸酯树脂和聚碳硅烷化合物的聚碳酸酯树脂组合物中，使用聚碳硅烷化合物可以改变聚碳酸酯树脂组合物的表面特性，而不会对聚碳酸酯树脂的固有特性产生不利影响，如透明度、耐热性和机械性能（例如冲击强度）。含有100质量部聚碳酸酯树脂、0.001至1质量部金属盐化合物和0.005至5质量部聚碳硅烷化合物的聚碳酸酯树脂组合物具有显著提高的阻燃性和高透明度，显著减少气体排放和模具污染，同时不会损失冲击强度和耐热性。
• Ligand-Enabled C–H Hydroxylation with Aqueous H₂O₂ at Room Temperature
  作者：Zhen Li、Han Seul Park、Jennifer X. Qiao、Kap-Sun Yeung、Jin-Quan Yu

  DOI：10.1021/jacs.2c08332

  日期：2022.10.5

  carboxyl-pyridone (CarboxPyridone) ligand that enables room-temperature Pd-catalyzed C–H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide (35% H2O2). The scalability of this methodology is demonstrated by a 1000 mmol scale reaction of ibuprofen (206 g) using only a 1 mol % Pd catalyst loading. The utility of this protocol is further

  随着过去十年中大量Pd(II)催化的天然底物C-H活化反应的发展，开发能够在安全实用的条件下使用绿色氧化剂的催化剂已成为一个日益重要的挑战。值得注意的是，Pd(II) 催化剂与可持续含水 H 2 O 2的相容性一直是包括瓦克型氧化在内的催化领域的长期挑战。我们在此报道了一种双功能双齿羧基吡啶酮 (CarboxPyridone) 配体，该配体能够使用工业兼容的氧化剂过氧化氢水溶液 (35% H 2 O)在室温下 Pd 催化的各种苯甲酸和苯乙酸的 C-H 羟基化反应。2）。仅使用 1 mol% Pd 催化剂负载的布洛芬 (206 g) 的 1000 mmol 规模反应证明了该方法的可扩展性。通过产品的衍生化以及从使用该方法制备的苯酚中间体合成多氟天然产物古美斯坦和紫檀烯，进一步说明了该协议的实用性。
• POLYCARBONATE RESIN COMPOSITION AND MOLDED ARTICLE
  申请人：Mitsubishi Engineering-Plastics Corporation

  公开号：EP2336247A1

  公开（公告）日：2011-06-22

  To provide a polycarbonate resin composition excellent in flame resistance, impact resistance and external appearance and a molded article formed from the polycarbonate resin composition. The composition comprises 0.001 to 2 parts by mass of a metal organic sulfonate (B), 0.001 to 1 parts by mass of a fluoropolymer (C), 0.5 to 5 parts by mass of polyalkylsilsesquioxane particles having an average particle diameter of 0.6 to 5 µm (D), and 0.5 to 8 parts by mass of a graft copolymer (E) having a butadiene content ratio of 50% to 90%, relative to 100 parts by mass of a polycarbonate resin (A).

  提供一种具有优异阻燃性、抗冲击性和外观的聚碳酸酯树脂组合物，以及一种由该聚碳酸酯树脂组合物形成的模塑制品。该组合物包括 0.001 至 2 份（按重量计）金属有机磺酸盐（B）、0.001 至 1 份（按重量计）含氟聚合物（C）、0.5 至 5 份（按重量计）平均颗粒直径为 0.6 至 5 微米的聚烷基硅倍半氧烷颗粒（D），以及 0.5 至 8 份（按重量计）接枝共聚物（E），相对于 100 份（按重量计）聚碳酸酯树脂（A），丁二烯含量比为 50%至 90%。
• Polycarbonate resin composition and formed product thereof
  申请人：Mitsubishi Engineering- Plastics Corporation

  公开号：EP2570458A1

  公开（公告）日：2013-03-20

  The present invention is directed to a polycarbonate resin composition comprising 0.01 to 1 part by mass of a metal salt compound and 0.01 to 5 parts by mass of a polysilane relative to 100 parts by mass of a polycarbonate resin, wherein the metal salt compound is an organic sulfonic acid alkali metal salt, and wherein the organic sulfonic acid alkali metal salt is at least one selected from a fluorine-containing aliphatic sulfonic acid alkali metal salt and an aromatic sulfonic acid alkali metal salt.

  本发明涉及一种聚碳酸酯树脂组合物，相对于 100 重量份的聚碳酸酯树脂，该组合物包含 0.01 至 1 重量份的金属盐化合物和 0.01 至 5 重量份的聚硅烷，其中金属盐化合物为有机磺酸碱金属盐，而有机磺酸碱金属盐至少选自含氟脂肪族磺酸碱金属盐和芳香族磺酸碱金属盐中的一种。
• Polycarbonate resin composition and molded object thereof
  申请人：MITSUBISHI ENGINEERING-PLASTICS CORPORATION

  公开号：EP2743314A1

  公开（公告）日：2014-06-18

  The present invention is directed to a polycarbonate resin composition comprising 0.01 to 1 part by mass of a metal salt compound and 0.3 to 5 parts by mass of a polysilane having an aryl group relative to 100 parts by mass of the polycarbonate resin, wherein the metal salt compound is an organic sulfonic acid alkali metal salt, wherein the organic sulfonic acid alkali metal salt is a fluorine-containing aliphatic sulfonic acid alkali metal salt, and wherein the polysilane has a number-average molecular weight of 300 to 200,000.

  本发明涉及一种聚碳酸酯树脂组合物，相对于 100 重量份的聚碳酸酯树脂，该组合物包含 0.01 至 1 重量份的金属盐化合物和 0.3 至 5 重量份的具有芳基的聚硅烷，其中金属盐化合物为有机磺酸碱金属盐，有机磺酸碱金属盐为含氟脂肪族磺酸碱金属盐，聚硅烷的数均分子量为 300 至 200,000 。