Di-n-propyl 4-hydroxyphthalate | 89926-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Di-n-propyl 4-hydroxyphthalate
• 英文别名: Dipropyl 4-hydroxybenzene-1,2-dicarboxylate
• CAS: 89926-33-0
• 化学式: C₁₄H₁₈O₅
• 分子量: 266.294
• InChiKey: YBDDIPXKLLBBCQ-UHFFFAOYSA-N

物化性质

• 沸点：
  383.5±22.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  丙醇 、 4-羟基邻苯二甲酸 在 硫酸 作用下， 以94.12 %的产率得到Di-n-propyl 4-hydroxyphthalate
  参考文献：
  名称：

  一种3,4’-氧双邻苯二甲酸酐的制备方法

  摘要：

  本发明公开了一种3,4'‑氧双邻苯二甲酸酐的制备方法，属于有机合成领域。本发明首先将4‑羟基邻苯二甲酸与醇类试剂发生酯化反应得到中间体I，然后将所述中间体I在碱性条件下与N‑甲基‑3‑氯邻苯二甲酰亚胺发生醚化反应形成中间体II，再将所述中间体II发生水解反应得到中间体III，最后将所述中间体III与乙酸酐发生成酐反应得到3,4'‑氧双邻苯二甲酸酐。通过四步反应实现转化，避免了现有工艺中存在异构体，及氧化路线，反应操作简单、条件温和、收率高、总成本较低。该工艺路线对环境更加友好、三废少、废水易于处理。

  公开号：

  CN116283856A

文献信息

• END-CAPPED POLY(ARYL ETHER SULFONE) POLYMERS, POLY(ARYL ETHER SULFONE) BLOCK COPOLYMERS, AND CORRESPONDING SYNTHESIS METHODS
  申请人：SOLVAY SPECIALTY POLYMERS USA, LLC

  公开号：US20210139650A1

  公开（公告）日：2021-05-13

  Described herein are end-capped poly(aryl ether sulfone) (“PAES”) polymers and corresponding synthesis methods. The end-capped PAES polymers are end-capped by functionalizing a PAES polymer with a halophthalic diialkyl ester end-capping agent. It was surprisingly discovered that the resulting dialkyl phthalate end-capped PAES polymers could be synthesized with significantly improved end-capping conversion rates, relative to end-capped PAES polymers directly functionalized with traditional phthalic anhydride end-capping agents. It was also surprisingly found that by heating the isopropyl phthalate end-capped PAES polymers, the polymers could be converted to the corresponding phthalic anhydride end-capped PAES polymers, yielding a more efficient synthetic route to phthalic anhydride end-capped PAES polymers.
• US4745026A
  申请人：——

  公开号：US4745026A

  公开（公告）日：1988-05-17
• US4833023A
  申请人：——

  公开号：US4833023A

  公开（公告）日：1989-05-23
• Structural essentials of xenoestrogen dialkyl phthalates to bind to the estrogen receptors
  作者：Daisuke Asai、Yoshiko Tahara、Makoto Nakai、Yoshikuni Yakabe、Mineo Takatsuki、Takeru Nose、Teruo Shinmyozu、Yasuyuki Shimohigashi

  DOI：10.1016/s0378-4274(00)00253-8

  日期：2000.12

  Xenoestrogen dialkyl phthalates. C6H4(COOCnHm)(2) lack the phenolic hydroxyl group that is an essential structural component of the steroid A ring of 17 beta -estradiol. In order to examine wh;ther dialkyl phthalates imitate the steroid structure, we have synthesized a series of 4-hydroxyl derivatives of dialkyl phthalates. The compounds were examined for their ability to displace [H-3]17 beta -estradiol from the recombinant human estrogen receptor, which was expressed on Sf9 cells using the vaculovirus expression system. Dialkyl 4-hydroxyl phthalates were found to exhibit several-fold higher binding affinities compared to phthalates without the 4-hydroxyl group. From the analyses of receptor binding modes of dialkyl phthalates with and without the 4-hydroxyl group. it was deduced that the phthalic benzene ring mimics the steroid A ring. A biphasic binding curve observed for dicyclohexyl phthalate was also depicted by its 4-hydroxyl derivative. but it increased binding affinity only at the high affinity binding site. These data suggest that the phthalate benzene moiety recognizes the core of the estrogen receptor binding site and the hydrophobic interaction of the dialkyl moiety substantiates the binding characteristics of the phthalates. The present data indicate that even chemicals with slight structural analogy and weak receptor affinity can perturb the endocrine system when administered in high concentrations. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.