4-[1-(4-Hydroxyphenyl)but-3-enyl]phenol | 577994-62-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[1-(4-Hydroxyphenyl)but-3-enyl]phenol
• CAS: 577994-62-8
• 化学式: C₁₆H₁₆O₂
• 分子量: 240.302
• InChiKey: FWJOYTYNJAGDFA-UHFFFAOYSA-N

物化性质

• 熔点：
  111-113 °C
• 沸点：
  397.6±32.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-acetyl-4,4-bis<4-(3-bromopropoxy)-3,5-dimethoxyphenyl>piperidine 、 4-[1-(4-Hydroxyphenyl)but-3-enyl]phenol 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以28%的产率得到1-(5,27,30,35-Tetramethoxy-16-prop-2-enylspiro[7,11,21,25-tetraoxapentacyclo[24.2.2.23,6.212,15.217,20]hexatriaconta-1(29),3,5,12(34),13,15(33),17,19,26(30),27,31,35-dodecaene-2,4'-piperidine]-1'-yl)ethanone
  参考文献：
  名称：

  Host−[2]Rotaxanes as Cellular Transport Agents

  摘要：

  Host-[2)rotaxanes, containing a diarginine-derivatized dibenzo-24-crown-8 (DB24C8) ether as the ring and a cyclophane pocket or an aromatic cleft as one blocking group, are cell transport agents. These hosts strongly associate with a variety of amino acids, dipeptides, and fluorophores in water (1 mM phosphate buffer, pH 7.0), DMSO, and a 75/25 (v/v) buffer to DMSO solution. All peptidic guests in all solvent systems have association constants (K-A's) in the range of 1 x 10(4) to 5 x 104 M-1, whereas the K-A range for the fluorophores is 1 x 10(4) to 9 x 10(5) m(-1). Association constants for the cyclophane itself, cyclophane 3, are smaller. These values are in the 1 x 10(3) to 5 x 10(3) m(-1) range, which shows that the rotaxane architecture is advantageous for guest binding. Cyclophane-[2]rotaxane 1 efficiently transports fluorescein and a fluorescein-protein kinase C (PKC) inhibitor into eukaryotic COS-7 cells, including the nucleus. Interestingly, cleft-[2)rotaxane 2 does not transport fluorescein as efficiently, even though the results from the fluorescence assays show that both [2]rotaxanes bind fluorescein with the same ability.

  DOI：

  10.1021/ja034918c
• 作为产物：
  描述：

  4,4'-二羟基二苯甲酮 在 sodium tetrahydroborate 、 lithium di-tert-butylbiphenylide 、 potassium carbonate 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 、 氯仿 为溶剂， 反应 96.0h， 生成 4-[1-(4-Hydroxyphenyl)but-3-enyl]phenol
  参考文献：
  名称：

  Host−[2]Rotaxanes as Cellular Transport Agents

  摘要：

  Host-[2)rotaxanes, containing a diarginine-derivatized dibenzo-24-crown-8 (DB24C8) ether as the ring and a cyclophane pocket or an aromatic cleft as one blocking group, are cell transport agents. These hosts strongly associate with a variety of amino acids, dipeptides, and fluorophores in water (1 mM phosphate buffer, pH 7.0), DMSO, and a 75/25 (v/v) buffer to DMSO solution. All peptidic guests in all solvent systems have association constants (K-A's) in the range of 1 x 10(4) to 5 x 104 M-1, whereas the K-A range for the fluorophores is 1 x 10(4) to 9 x 10(5) m(-1). Association constants for the cyclophane itself, cyclophane 3, are smaller. These values are in the 1 x 10(3) to 5 x 10(3) m(-1) range, which shows that the rotaxane architecture is advantageous for guest binding. Cyclophane-[2]rotaxane 1 efficiently transports fluorescein and a fluorescein-protein kinase C (PKC) inhibitor into eukaryotic COS-7 cells, including the nucleus. Interestingly, cleft-[2)rotaxane 2 does not transport fluorescein as efficiently, even though the results from the fluorescence assays show that both [2]rotaxanes bind fluorescein with the same ability.

  DOI：

  10.1021/ja034918c

文献信息

• BIOFUEL PRODUCTION
  申请人：Bio Architecture Lab, Inc.

  公开号：EP2195440A2

  公开（公告）日：2010-06-16
• ISOLATED ALCOHOL DEHYDROGENASE ENZYMES AND USES THEREOF
  申请人：Bio Architecture Lab, Inc.

  公开号：EP2245162A2

  公开（公告）日：2010-11-03
• MODIFIED PHOTOSYNTHETIC MICROORGANISMS FOR CONTINUOUS PRODUCTION OF CARBON-CONTAINING COMPOUNDS
  申请人：Matrix Genetics, LLC

  公开号：EP2809790A2

  公开（公告）日：2014-12-10
• ENHANCING FERMENTATION OF STARCH-AND SUGAR-BASED FEEDSTOCKS
  申请人：Sweetwater Energy, Inc.

  公开号：EP2812437A1

  公开（公告）日：2014-12-17
• METHODS AND SYSTEMS FOR SACCHARIFICATION OF BIOMASS
  申请人：Sweetwater Energy, Inc.

  公开号：EP2836602A1

  公开（公告）日：2015-02-18