Synthesis of 1-H-1,5-benzodiazepines derivatives using SiO2/ZnCl2
作者:Raquel G. Jacob、Cátia S. Radatz、Mariele B. Rodrigues、Diego Alves、Gelson Perin、Eder J. Lenardão、Lucielli Savegnago
DOI:10.1002/hc.20674
日期:——
A general and easy method for the synthesis of several 1-H-1,5-benzodiazepines using SiO2/ZnCl2 under solvent-free conditions is described. This efficient and improved method furnishes selectively and in good yields the corresponding 1-H-1,5-benzodiazepines derivatives starting from o-phenylenediamine and cyclic or acyclicketones. The catalytic system was reused up four times, and the use of focused
RuCl<sub>3</sub>·<i>x</i>H<sub>2</sub>O: A Novel and Efficient Catalyst for the Facile Synthesis of 1,5-Benzodiazepines Under Solvent-Free Conditions
作者:Suresh、Anil Saini、Jagir S. Sandhu
DOI:10.1080/00397910802109273
日期:2008.8.29
Abstract 1,5-Benzodizepines are synthesized in excellent yields via condensation of o-phenylenediamine with ketones having a hydrogen at the α-position. The reaction is performed in solvent-freeconditions and 5 mol% of RuCl3·xH2O is enough to direct the reaction to completion.
Bi(NO3)3•5H2O: An Efficient and Green Catalyst for Synthesis of 1,5-Benzodiazepines and b-Amino Carbonyl Compounds
作者:Jaspreet Kaur Rajput、Gagandeep Kaur
DOI:10.14233/ajchem.2013.14353
日期:——
Bismuth nitrate pentahydrate is found to be an efficient catalyst for the synthesis of 1,5-benzodiazepines and b-amino carbonyl compounds using condensation of o-phenylenediamine with ketones and one pot three component Mannich reaction, respectively under solvent free conditions at room temperature. This method offers a simple, solvent free, room temperature, environment friendly synthesis of 1,5-benzodiazepines and b-amino carbonyl compounds. The products are isolated by column chromatography and recrystallization, respectively and were characterized by their melting point, IR and 1H NMR spectroscopy.
Silica gel-supported sulfuric acid catalyzed synthesis of 1,5-benzodiazepine derivatives
作者:D. Shobha、M. Adharvana Chari、K. Mukkanti、K. H. Ahn
DOI:10.1002/jhet.174
日期:2009.9
Silica gel-supported sulfuricacid has been found to be an efficient catalyst for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones in acetonitrile solvent. This method is simple, effective, and environmentally friendly and gives better yields. Compared to the classical reaction conditions, this new method consistently has the advantage of excellent yields (80–97%) and short
Novel, reusable, and efficient (Cd, Zn) S nanocatalysts were prepared by simple and economical chemical bath deposition using a greener approach. The as-synthesized catalysts were characterized by XRD, SEM, TEM, and FT-IR spectroscopy. The catalytic activity of as-prepared nanocatalysts were examined for the synthesis of 1,5-benzodiazepines and its derivatives under solvent-free conditions without using any toxic materials. It has been observed that CdS nanocatalyst shows superior catalytic activity and is recyclable and reusable for ten runs without any significant loss.