Methyl 12-(tetrahydropyranyloxy)octadecanoate | 138982-91-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl 12-(tetrahydropyranyloxy)octadecanoate
• 英文别名: methyl 12-O-tetrahydropyranylstearate；Methyl 12-(oxan-2-yloxy)octadecanoate
• CAS: 138982-91-9
• 化学式: C₂₄H₄₆O₄
• 分子量: 398.627
• InChiKey: UFJZEAUXDGGBPK-UHFFFAOYSA-N

物化性质

• 沸点：
  473.3±30.0 °C(Predicted)
• 密度：
  0.94±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  28
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 12-(tetrahydropyranyloxy)octadecanoate 在 氢氧化钾 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 1.5h， 以98.8%的产率得到12-(Tetrahydropyranyloxy)octadecanoic acid
  参考文献：
  名称：

  Use of esters or amides of hydroxylated carboxylic acids as solubilizers

  摘要：

  描述了羟基化羧酸酯或酰胺作为溶剂，特别是用于制药、化妆品和食品制剂的用途。

  公开号：

  US06365637B1
• 作为产物：
  描述：

  12-羟基硬脂酸 在 氢气 作用下， 生成 Methyl 12-(tetrahydropyranyloxy)octadecanoate
  参考文献：
  名称：

  Cesium fluoride-promoted esterification of carboxylic acids. A practical alternative to the diazomethane method and direct conversion of organotin carboxylates

  摘要：

  DOI：

  10.1021/jo00033a048

文献信息

• LEAVE-ON NON-SOLID SKIN CONDITIONING COMPOSITIONS CONTAINING 12-[(12-HYDROXYOCTADECANOYL)OXY]OCTADECANOIC ACID
  申请人：Unilever PLC

  公开号：EP2637746A2

  公开（公告）日：2013-09-18
• LEAVE-ON NONSOLID SKIN CONDITIONING COMPOSITIONS CONTAINING 12-[(12-HYDROXYOCTADECANOYL)OXY] OCTADECANOIC ACID
  申请人：Madison Stephen Alan

  公开号：US20120122936A1

  公开（公告）日：2012-05-17

  Leave-on non-solid skin conditioning compositions containing 12-[(12-hydroxyoctadecanoyl)oxy]octadecanoic acid. 12[(12-hydroxyoctadecanoyl)oxy]octadecanoic acid can be easily incorporated in combination with lipophilic carriers that are liquid at room temperature. Compositions are able to deliver increased energy production by human fibroblasts. Preferred compositions also contain 12-hydroxy stearic acid and thus are able to deliver a wide range of skin benefits.
• US6365637B1
  申请人：——

  公开号：US6365637B1

  公开（公告）日：2002-04-02
• [EN] LEAVE-ON NON-SOLID SKIN CONDITIONING COMPOSITIONS CONTAINING 12-[(12-HYDROXYOCTADECANOYL)OXY] OCTADECANOIC ACID<br/>[FR] COMPOSITIONS REVITALISANTES NON SOLIDES À LAISSER SUR LA PEAU, CONTENANT DE L'ACIDE 12-[(12-HYDROXYOCTADÉCANOYL)OXY] OCTADÉCANOÏQUE
  申请人：UNILEVER PLC

  公开号：WO2012062554A2

  公开（公告）日：2012-05-18

  Leave-on non-solid skin conditioning compositions containing 12-[(12- hydroxyoctadecanoyl)oxy] octadecanoic acid. 12-[(12-hydroxyoctadecanoyl)oxy] octadecanoic acid can be easily incorporated in combination with lipophilic carriers that are liquid at room temperature. Compositions are able to deliver increased energy production by human fibroblasts. Preferred compositions also contain 12-hydroxystearic acid and thus are able to deliver a wide range of skin benefits.
• Cesium fluoride-promoted esterification of carboxylic acids. A practical alternative to the diazomethane method and direct conversion of organotin carboxylates
  作者：Tsuneo Sato、Junzo Otera、Hitosi Nozaki

  DOI：10.1021/jo00033a048

  日期：1992.3